Detail Information

Basic Information:


  VIRBase ID:  

VHID00290191

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:           C2CD2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART1-5p C2CD2
miRBase
Accession/Entrez ID		 MIMAT0000999 25966
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - C21orf25//C21orf258//TMEM24L

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR C2CD2
chr21:43315911(-) A-I      intronic
chr21:43356988(-) A-I      intronic
chr21:43357020(-) A-I      intronic
chr21:43357039(-) A-I      intronic
chr21:43357056(-) A-I      intronic
chr21:43357092(-) A-I      intronic
chr21:43357110(-) A-I      intronic
chr21:43357143(-) A-I      intronic
chr21:43357323(-) A-I      intronic
chr21:43357324(-) A-I      intronic
chr21:43357363(-) A-I      intronic
chr21:43357385(-) A-I      intronic
chr21:43357401(-) A-I      intronic
chr21:43357410(-) A-I      intronic
chr21:43357421(-) A-I      intronic
chr21:43357431(-) A-I      intronic
chr21:43356959(-) A-I      intronic
chr21:43358885(-) A-I      intronic
chr21:43358947(-) A-I      intronic
chr21:43358948(-) A-I      intronic
chr21:43361346(-) A-I      intronic
chr21:43361370(-) A-I      intronic
chr21:43363396(-) A-I      intronic
chr21:43363398(-) A-I      intronic
chr21:43355813(-) A-I      intronic
chr21:43355177(-) A-I      intronic
chr21:43355171(-) A-I      intronic
chr21:43355165(-) A-I      intronic
chr21:43355133(-) A-I      intronic
chr21:43355129(-) A-I      intronic
chr21:43354532(-) A-I      intronic
chr21:43354524(-) A-I      intronic
chr21:43354427(-) A-I      intronic
chr21:43350647(-) A-I      intronic
chr21:43357432(-) A-I      intronic
chr21:43350622(-) A-I      intronic
chr21:43350582(-) A-I      intronic
chr21:43349193(-) A-I      intronic
chr21:43309853(-) A-I      intronic
chr21:43356962(-) A-I      intronic
chr21:43356964(-) A-I      intronic
chr21:43356966(-) A-I      intronic
chr21:43354293(-) A-I      intronic
chr21:43355139(-) A-I      intronic
chr21:43355719(-) A-I      intronic
chr21:43361342(-) A-I      intronic
chr21:43363180(-) A-I      intronic
chr21:43355947(-) A-I      intronic
chr21:43357498(-) A-I      intronic
chr21:43363356(-) A-I      intronic
chr21:43351670(-) A-I      intronic
chr21:43355763(-) A-I      intronic
chr21:43355030(-) A-I      intronic
chr21:43364568(-) A-I      intronic
chr21:43309879(-) A-I      intronic
chr21:43357123(-) A-I      intronic
chr21:43343151(-) A-I      intronic
chr21:43357262(-) A-I      intronic
chr21:43355849(-) A-I      intronic
chr21:43355035(-) A-I      intronic
chr21:43355034(-) A-I      intronic
chr21:43313171(-) A-I      intronic
chr21:43363394(-) A-I      intronic
chr21:43354345(-) A-I      intronic
chr21:43361358(-) A-I      intronic
chr21:43354350(-) A-I      intronic
chr21:43313424(-) A-I      intronic
chr21:43361418(-) A-I      intronic
chr21:43357499(-) A-I      intronic
chr21:43354368(-) A-I      intronic
chr21:43363162(-) A-I      intronic
chr21:43313470(-) A-I      intronic
chr21:43357065(-) A-I      intronic
chr21:43355798(-) A-I      intronic
chr21:43355898(-) A-I      intronic
chr21:43357148(-) A-I      intronic
chr21:43363348(-) A-I      intronic
chr21:43313381(-) A-I      intronic
chr21:43355138(-) A-I      intronic
chr21:43309847(-) A-I      intronic
chr21:43313159(-) A-I      intronic
chr21:43313220(-) A-I      intronic
chr21:43363339(-) A-I      intronic
chr21:43313199(-) A-I      intronic
chr21:43313432(-) A-I      intronic
chr21:43355731(-) A-I      intronic
chr21:43313181(-) A-I      intronic
chr21:43355951(-) A-I      intronic
chr21:43354512(-) A-I      intronic
chr21:43325421(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED C2CD2
chr21:43319401(-) A-I exon CDS    19478186
chr21:43361271(-) A-I intron -    22327324
chr21:43313829(-) C-A intron -    22484847
chr21:43314080(-) A-G intron -    22484847
chr21:43314081(-) A-G intron -    22484847
chr21:43357065(-) A-G intron -    22484847
chr21:43361271(-) A-G intron -    22484847
chr21:43314444(-) A-G intron -    22484847
chr21:43315910(-) A-G intron -    22484847
chr21:43361015(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase C2CD2
chr21:43305225-43305226(-) m6A 3'UTR       24981863//27773535
chr21:43305258-43305259(-) m6A 3'UTR       24284625//24981863//27773535
chr21:43305264-43305265(-) m6A 3'UTR       24284625//24981863//27773535
chr21:43305327-43305328(-) m6A 3'UTR       24284625//25456834//24981863//27773535
chr21:43305376-43305377(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535
chr21:43305458-43305459(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535
chr21:43305562-43305563(-) m6A 3'UTR       24284625//24981863
chr21:43305601-43305602(-) m6A 3'UTR       24284625//24981863//22575960
chr21:43305651-43305652(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr21:43305659-43305660(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr21:43305669-43305670(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr21:43305703-43305704(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr21:43305725-43305726(-) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960
chr21:43305749-43305750(-) m6A 3'UTR       24284625//24981863//22575960
chr21:43305786-43305787(-) m6A 3'UTR       24284625//24981863
chr21:43308108-43308109(-) m6A 3'UTR//exon       24981863
chr21:43308117-43308118(-) m6A 3'UTR//exon       24981863
chr21:43308160-43308161(-) m6A 3'UTR//exon       24981863
chr21:43308173-43308174(-) m6A 3'UTR//exon       24981863
chr21:43308210-43308211(-) m6A 3'UTR//exon       24981863//27773535
chr21:43308219-43308220(-) m6A 3'UTR//exon       24981863//27773535
chr21:43308306-43308307(-) m6A 3'UTR//exon       27773535
chr21:43308346-43308347(-) m6A 3'UTR//exon       27773535
chr21:43308359-43308360(-) m6A 3'UTR//exon       27773535
chr21:43308417-43308418(-) m6A 3'UTR//exon       27773535
chr21:43308574-43308575(-) m6A 3'UTR//exon       24981863
chr21:43308606-43308607(-) m6A 3'UTR//exon       24981863//27773535
chr21:43308612-43308613(-) m6A 3'UTR//exon       24981863//27773535
chr21:43308709-43308710(-) m6A 3'UTR//exon       24981863//27773535
chr21:43308831-43308832(-) m6A 3'UTR//exon       24981863//27773535
chr21:43308883-43308884(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr21:43309006-43309007(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960
chr21:43309043-43309044(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960
chr21:43309085-43309086(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535
chr21:43309269-43309270(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27773536//22575960
chr21:43309275-43309276(-) m6A CDS//exon       24284625//25456834//24981863//27773535//27773536//22575960
chr21:43309302-43309303(-) m6A CDS//exon       24284625//25456834//24981863//27773536//22575960
chr21:43309395-43309396(-) m6A CDS//exon       24284625//25456834//24981863
chr21:43328459-43328460(-) m6A exon//intron       27773535
chr21:43328482-43328483(-) m6A exon//intron       27773535
chr21:43362325-43362326(-) m6A CDS       27773536
chr21:43373133-43373134(-) m6A exon//intron       24981863//27773536
chr21:43373211-43373212(-) m6A exon//intron       -
chr21:43373231-43373232(-) m6A exon//intron       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate C2CD2
Chromatin K562 cells     -
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug ebv-miR-BART1-5p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART1-5p
Interactor2: C2CD2

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

Starting a new search, please wait ...