Detail Information

Basic Information:


  VIRBase ID:  

VHID00290133

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:           DICER1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART1-5p DICER1
miRBase
Accession/Entrez ID		 MIMAT0000999 23405
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - DCR1//Dicer//Dicer1e//GLOW//HERNA//K12H4.8-LIKE//MNG1//RMSE2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DICER1
chr14:95617269(-) A-I      intronic
chr14:95617234(-) A-I      intronic
chr14:95617267(-) A-I      intronic
chr14:95617338(-) A-I      intronic
chr14:95617317(-) A-I      intronic
chr14:95608532(-) A-I      intronic
chr14:95614285(-) A-I      intronic
chr14:95617280(-) A-I      intronic
chr14:95597526(-) A-I      intronic
chr14:95616760(-) A-I      intronic
chr14:95616576(-) A-I      intronic
chr14:95616771(-) A-I      intronic
chr14:95617357(-) A-I      intronic
chr14:95617355(-) A-I      intronic
chr14:95615385(-) A-I      intronic
chr14:95616741(-) A-I      intronic
chr14:95617292(-) A-I      intronic
chr14:95613681(-) A-I      intronic
chr14:95597535(-) A-I      intronic
chr14:95617300(-) A-I      intronic
chr14:95617325(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DICER1
chr14:95615385(-) A-G intron -    22484847
chr14:95616576(-) A-G intron -    22484847
chr14:95617280(-) A-G intron -    22484847
chr14:95617300(-) A-G intron -    22484847
chr14:95617325(-) A-G intron -    22484847
chr14:95617355(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DICER1
chr14:95552701-95552702(-) m6A 3'UTR       27773535
chr14:95553018-95553019(-) m6A 3'UTR       27773535
chr14:95553532-95553533(-) m6A 3'UTR       -
chr14:95554128-95554129(-) m6A 3'UTR       24981863
chr14:95555754-95555755(-) m6A 3'UTR//intron       27773535
chr14:95555818-95555819(-) m6A 3'UTR//intron       27773535
chr14:95555825-95555826(-) m6A 3'UTR//intron       27773535
chr14:95556649-95556650(-) m6A 3'UTR//intron       27773535
chr14:95556677-95556678(-) m6A 3'UTR//intron       27773535//22608085
chr14:95556757-95556758(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556800-95556801(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556805-95556806(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556812-95556813(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556832-95556833(-) m6A 3'UTR//intron       24981863//27773535//22608085
chr14:95556986-95556987(-) m6A CDS//exon       24981863//27773535
chr14:95560387-95560388(-) m6A CDS       27773535
chr14:95560420-95560421(-) m6A CDS       27773535
chr14:95560450-95560451(-) m6A CDS       27773535
chr14:95561748-95561749(-) m6A 3'UTR//intron       27773535
chr14:95561756-95561757(-) m6A 3'UTR//intron       27773535
chr14:95562141-95562142(-) m6A CDS//intron       22608085
chr14:95562284-95562285(-) m6A CDS       24284625//24981863//27773535//22608085
chr14:95562349-95562350(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr14:95562409-95562410(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562467-95562468(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562574-95562575(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562655-95562656(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95562912-95562913(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr14:95563020-95563021(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95563042-95563043(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95566153-95566154(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr14:95566230-95566231(-) m6A CDS       27773535
chr14:95569847-95569848(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95569867-95569868(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95569935-95569936(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr14:95570052-95570053(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95570148-95570149(-) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085
chr14:95570277-95570278(-) m6A CDS//exon       24284625//24981863//22608085
chr14:95570314-95570315(-) m6A CDS//exon       24284625//24981863//22608085
chr14:95570448-95570449(-) m6A CDS//exon//intron       24284625//22608085
chr14:95572444-95572445(-) m6A CDS//exon       27773535
chr14:95572465-95572466(-) m6A CDS//exon       27773535
chr14:95574735-95574736(-) Tm CDS       -
chr14:95583004-95583005(-) m6A CDS//intron       24981863//27773535
chr14:95583967-95583968(-) m6A CDS//exon       24981863//27773535
chr14:95583991-95583992(-) m6A CDS//exon       24981863//27773535
chr14:95584024-95584025(-) m6A CDS//exon       24981863//27773535
chr14:95584069-95584070(-) m6A CDS//exon       24981863//27773535//22608085
chr14:95590535-95590536(-) m6A CDS//exon       24981863//27773535//22608085
chr14:95590614-95590615(-) m6A CDS       24284625//24981863//26404942//27773535//22608085
chr14:95590744-95590745(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590771-95590772(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590862-95590863(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr14:95590906-95590907(-) m6A CDS       24284625//24981863//22608085
chr14:95590924-95590925(-) m6A CDS       24284625//24981863//22608085
chr14:95590966-95590967(-) m6A CDS       24284625//24981863//22608085
chr14:95590994-95590995(-) m6A CDS       24284625//24981863//22608085
chr14:95592919-95592920(-) m6A CDS       24284625//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DICER1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug ebv-miR-BART1-5p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART1-5p
Interactor2: DICER1

Evidence Support:


Strong-Evidence Luciferase reporter assay
Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VmiReg

References:


[1]PMID 22100165 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.
[2]PMID 22291592 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description Of the 12 PAR-CLIP-identified target 3'UTRs tested against EBV miRNAs, 11 3'UTRs (BACH1, CLEC2D, CLIP1, DAZAP2, KDM4B, LY75, OTUD1, PDE7A, PELI1, SP100, ZNF451) resulted in luciferase inhibition following ectopic viral miRNA expression (Figure S3).

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