Basic Information:

  VIRBase ID:  

VHID00289982

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:  MIMAT0000999          PXMP4:  NM_183397     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART1-5p	PXMP4
miRBase Accession/Entrez ID	MIMAT0000999	11264
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PMP24

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PXMP4	chr20:32293936(-) A-I      3'UTR chr20:32302159(-) A-I      intronic chr20:32293964(-) A-I      3'UTR chr20:32292802(-) A-I      3'UTR chr20:32293969(-) A-I      3'UTR chr20:32292810(-) A-I      3'UTR chr20:32294210(-) A-I      3'UTR chr20:32292812(-) A-I      3'UTR chr20:32292813(-) A-I      3'UTR chr20:32292817(-) A-I      3'UTR chr20:32292819(-) A-I      3'UTR chr20:32294823(-) A-I      3'UTR chr20:32293920(-) A-I      3'UTR chr20:32292818(-) A-I      3'UTR chr20:32293107(-) A-I      3'UTR chr20:32296960(-) A-I      intronic chr20:32304872(-) A-I      intronic chr20:32304862(-) A-I      intronic chr20:32304840(-) A-I      intronic chr20:32303388(-) A-I      intronic chr20:32299691(-) A-I      intronic chr20:32299684(-) A-I      intronic chr20:32299431(-) A-I      intronic chr20:32304901(-) A-I      intronic chr20:32304902(-) A-I      intronic chr20:32306884(-) A-I      intronic chr20:32296605(-) A-I      intronic chr20:32306974(-) A-I      intronic chr20:32306975(-) A-I      intronic chr20:32306981(-) A-I      intronic chr20:32296573(-) A-I      intronic chr20:32292963(-) A-I      3'UTR chr20:32292964(-) A-I      3'UTR chr20:32292966(-) A-I      3'UTR chr20:32292969(-) A-I      3'UTR chr20:32292978(-) A-I      3'UTR chr20:32292989(-) A-I      3'UTR chr20:32292990(-) A-I      3'UTR chr20:32292991(-) A-I      3'UTR chr20:32292997(-) A-I      3'UTR chr20:32293000(-) A-I      3'UTR chr20:32293009(-) A-I      3'UTR chr20:32293023(-) A-I      3'UTR chr20:32293028(-) A-I      3'UTR chr20:32293052(-) A-I      3'UTR chr20:32293203(-) A-I      3'UTR chr20:32293226(-) A-I      3'UTR chr20:32293349(-) A-I      3'UTR chr20:32293354(-) A-I      3'UTR chr20:32293405(-) A-I      3'UTR chr20:32293409(-) A-I      3'UTR chr20:32293746(-) A-I      3'UTR chr20:32293747(-) A-I      3'UTR chr20:32293749(-) A-I      3'UTR chr20:32293797(-) A-I      3'UTR chr20:32293892(-) A-I      3'UTR chr20:32293896(-) A-I      3'UTR chr20:32293908(-) A-I      3'UTR chr20:32292975(-) A-I      3'UTR chr20:32293911(-) A-I      3'UTR chr20:32293925(-) A-I      3'UTR chr20:32293935(-) A-I      3'UTR chr20:32293945(-) A-I      3'UTR chr20:32294132(-) A-I      3'UTR chr20:32294139(-) A-I      3'UTR chr20:32294147(-) A-I      3'UTR chr20:32294154(-) A-I      3'UTR chr20:32294177(-) A-I      3'UTR chr20:32294765(-) A-I      3'UTR chr20:32294771(-) A-I      3'UTR chr20:32294781(-) A-I      3'UTR chr20:32292816(-) A-I      3'UTR chr20:32292814(-) A-I      3'UTR chr20:32292832(-) A-I      3'UTR chr20:32292835(-) A-I      3'UTR chr20:32292837(-) A-I      3'UTR chr20:32292917(-) A-I      3'UTR chr20:32292928(-) A-I      3'UTR chr20:32292940(-) A-I      3'UTR chr20:32293959(-) A-I      3'UTR chr20:32292952(-) A-I      3'UTR chr20:32300341(-) A-I      intronic chr20:32302133(-) A-I      intronic chr20:32302145(-) A-I      intronic chr20:32299416(-) A-I      intronic chr20:32300863(-) A-I      intronic chr20:32299625(-) A-I      intronic chr20:32296435(-) A-I      intronic chr20:32296953(-) A-I      intronic chr20:32296451(-) A-I      intronic chr20:32300612(-) A-I      intronic chr20:32300384(-) A-I      intronic chr20:32302083(-) A-I      intronic chr20:32303931(-) A-I      intronic chr20:32300849(-) A-I      intronic chr20:32296130(-) A-I      intronic chr20:32300690(-) A-I      intronic chr20:32296031(-) A-I      intronic chr20:32293804(-) A-I      3'UTR chr20:32294958(-) A-I      3'UTR chr20:32294004(-) A-I      3'UTR chr20:32294800(-) A-I      3'UTR chr20:32293285(-) A-I      3'UTR chr20:32293218(-) A-I      3'UTR chr20:32294005(-) A-I      3'UTR chr20:32294201(-) A-I      3'UTR chr20:32294119(-) A-I      3'UTR chr20:32293178(-) A-I      3'UTR chr20:32294176(-) A-I      3'UTR chr20:32293789(-) A-I      3'UTR chr20:32292944(-) A-I      3'UTR chr20:32293162(-) A-I      3'UTR chr20:32293068(-) A-I      3'UTR chr20:32293928(-) A-I      3'UTR chr20:32294918(-) A-I      3'UTR chr20:32293151(-) A-I      3'UTR chr20:32292924(-) A-I      3'UTR chr20:32293295(-) A-I      3'UTR chr20:32292874(-) A-I      3'UTR chr20:32293182(-) A-I      3'UTR chr20:32293240(-) A-I      3'UTR chr20:32292806(-) A-I      3'UTR chr20:32293364(-) A-I      3'UTR chr20:32292854(-) A-I      3'UTR chr20:32292831(-) A-I      3'UTR chr20:32293860(-) A-I      3'UTR chr20:32293927(-) A-I      3'UTR chr20:32293014(-) A-I      3'UTR chr20:32294153(-) A-I      3'UTR chr20:32294868(-) A-I      3'UTR chr20:32294141(-) A-I      3'UTR chr20:32293163(-) A-I      3'UTR chr20:32292960(-) A-I      3'UTR chr20:32292933(-) A-I      3'UTR chr20:32293870(-) A-I      3'UTR chr20:32293063(-) A-I      3'UTR chr20:32293792(-) A-I      3'UTR chr20:32293385(-) A-I      3'UTR chr20:32293243(-) A-I      3'UTR chr20:32294805(-) A-I      3'UTR chr20:32294923(-) A-I      3'UTR chr20:32293744(-) A-I      3'UTR chr20:32293373(-) A-I      3'UTR chr20:32294942(-) A-I      3'UTR chr20:32293135(-) A-I      3'UTR chr20:32293999(-) A-I      3'UTR chr20:32294187(-) A-I      3'UTR chr20:32293970(-) A-I      3'UTR chr20:32292856(-) A-I      3'UTR chr20:32300353(-) A-I      intronic chr20:32300504(-) A-I      intronic chr20:32303844(-) A-I      intronic chr20:32300610(-) A-I      intronic chr20:32297097(-) A-I      intronic chr20:32306840(-) A-I      intronic chr20:32304815(-) A-I      intronic chr20:32302262(-) A-I      intronic chr20:32296171(-) A-I      intronic chr20:32306127(-) A-I      intronic chr20:32296095(-) A-I      intronic chr20:32300569(-) A-I      intronic chr20:32302243(-) A-I      intronic chr20:32296612(-) A-I      intronic chr20:32299430(-) A-I      intronic chr20:32296991(-) A-I      intronic chr20:32303014(-) A-I      intronic chr20:32296225(-) A-I      intronic chr20:32300601(-) A-I      intronic chr20:32296952(-) A-I      intronic chr20:32296635(-) A-I      intronic chr20:32296172(-) A-I      intronic chr20:32297017(-) A-I      intronic chr20:32302242(-) A-I      intronic chr20:32300526(-) A-I      intronic chr20:32296085(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PXMP4	chr20:32292944(-) A-I exon 3'UTR    22327324 chr20:32294181(-) A-I exon 3'UTR    21960545   //22327324 chr20:32294201(-) A-I exon 3'UTR    22327324 chr20:32292831(-) A-I exon 3'UTR    21960545 chr20:32292856(-) A-I exon 3'UTR    21960545 chr20:32293792(-) A-I exon 3'UTR    21960545 chr20:32294141(-) A-I exon 3'UTR    21960545 chr20:32294180(-) A-I exon 3'UTR    21960545 chr20:32294187(-) A-I exon 3'UTR    21960545 chr20:32293554(-) A-I exon 3'UTR    21960545 chr20:32292856(-) A-G exon 3'UTR    22484847 chr20:32292924(-) A-G exon 3'UTR    22484847 chr20:32292934(-) A-G exon 3'UTR    22484847 chr20:32292944(-) A-G exon 3'UTR    22484847 chr20:32293373(-) A-G exon 3'UTR    22484847 chr20:32294119(-) A-G exon 3'UTR    22484847 chr20:32294141(-) A-G exon 3'UTR    22484847 chr20:32294153(-) A-G exon 3'UTR    22484847 chr20:32294180(-) A-G exon 3'UTR    22484847 chr20:32294181(-) A-G exon 3'UTR    22484847 chr20:32294201(-) A-G exon 3'UTR    22484847 chr20:32296085(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PXMP4	chr20:32294878-32294879(-) m6A 3'UTR       24981863 chr20:32294901-32294902(-) m6A 3'UTR       24981863 chr20:32295108-32295109(-) m6A 3'UTR       27773535 chr20:32295267-32295268(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr20:32295375-32295376(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22608085 chr20:32295419-32295420(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr20:32295462-32295463(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr20:32295548-32295549(-) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr20:32295575-32295576(-) m6A 3'UTR//CDS       24284625//24981863//27773535 chr20:32295689-32295690(-) m6A 3'UTR//CDS       24284625//27773535 chr20:32295700-32295701(-) m6A 3'UTR//CDS       24284625//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PXMP4	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HeLa-S3 cells|K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART1-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART1-5p
Interactor2: PXMP4

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.