Basic Information:

  VIRBase ID:  

VHID00289805

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9630

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:  MIMAT0000999          BCL2L11:  NM_138625     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART1-5p	BCL2L11
miRBase Accession/Entrez ID	MIMAT0000999	10018
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BAM//BIM//BOD

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BCL2L11	chr2:111908621(+) A-I      intronic chr2:111910902(+) A-I      intronic chr2:111910845(+) A-I      intronic chr2:111908741(+) A-I      intronic chr2:111887910(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BCL2L11	chr2:111877031-111877032(+) m6A 5'UTR       24284625 chr2:111877092-111877093(+) m6A 5'UTR       - chr2:111877118-111877119(+) m6A 5'UTR       - chr2:111878633-111878634(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863 chr2:111878750-111878751(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863 chr2:111880354-111880355(+) m6A 5'UTR//intron       24209618 chr2:111880361-111880362(+) m6A 5'UTR//intron       24209618 chr2:111881317-111881318(+) m6A 5'UTR       - chr2:111881372-111881373(+) m6A CDS       - chr2:111881408-111881409(+) m6A CDS       - chr2:111881433-111881434(+) m6A CDS       - chr2:111881479-111881480(+) m6A CDS//intron       - chr2:111921740-111921741(+) m6A 3'UTR//CDS       24284625//24981863 chr2:111921840-111921841(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:111921857-111921858(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:111921866-111921867(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:111921946-111921947(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:111921963-111921964(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr2:111922057-111922058(+) m6A 3'UTR       24981863 chr2:111923245-111923246(+) m6A 3'UTR       24981863 chr2:111923292-111923293(+) m6A 3'UTR       24981863 chr2:111923304-111923305(+) m6A 3'UTR       24981863 chr2:111923331-111923332(+) m6A 3'UTR       24981863 chr2:111923344-111923345(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	BCL2L11	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART1-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART1-5p
Interactor2: BCL2L11

Evidence Support:

Strong-Evidence	Luciferase reporter assay//Northern blot//qRT-PCR
Prediction-Evidence	miRanda//PITA
Support Database	ViRBase//VmiReg

References:

[1]PMID	21333317	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	AGS cells//C666-1 cells	Interactor2 expression	Downregulation
Description	Analysis of the BimEL protein levels in cells expressing the miRNAs revealed that its expression was affected by several of the individual miRNAs with cell lines expressing miR-BART1, 3, 9, 11 and 12 all having decreased BimEL levels (Figure 6B and C).

[2]PMID	23342366	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	AGS cells//C666-1 cells	Interactor2 expression	Downregulation
Description	EBV-encoded BART miRNAs target the 3'-UTRs of viral genes, such as LMP1, BALF5, and LMP2A genes, and negatively regulate expression of these viral genes.On the other hand, EBV miRNAs repress cellular proteins, which include p53 up-regulated modulator of apoptosis(PUMA), DICER1, and BIM. Table 2 EBV-derived miRNAs and their target genes.