Detail Information

Basic Information:


  VIRBase ID:  

VHID00289795

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:           HS3ST3B1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BART1-5p HS3ST3B1
miRBase
Accession/Entrez ID		 MIMAT0000999 9953
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - 3-OST-3B//3OST3B1//h3-OST-3B

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HS3ST3B1
chr17:14228277(+) A-I      intronic
chr17:14228290(+) A-I      intronic
chr17:14228296(+) A-I      intronic
chr17:14228295(+) A-I      intronic
chr17:14228297(+) A-I      intronic
chr17:14246373(+) A-I      intronic
chr17:14247340(+) A-I      intronic
chr17:14247343(+) A-I      intronic
chr17:14218890(+) A-I      intronic
chr17:14238805(+) A-I      intronic
chr17:14230159(+) A-I      intronic
chr17:14218954(+) A-I      intronic
chr17:14236529(+) A-I      intronic
chr17:14241816(+) A-I      intronic
chr17:14217377(+) A-I      intronic
chr17:14218963(+) A-I      intronic
chr17:14236637(+) A-I      intronic
chr17:14217376(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED HS3ST3B1
chr17:14232451(+) A-I intron -    19478186

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HS3ST3B1
chr17:14204459-14204460(+) m6A 5'UTR       24981863
chr17:14204724-14204725(+) m6A 5'UTR       25456834
chr17:14204757-14204758(+) m6A 5'UTR       25456834//24981863
chr17:14204785-14204786(+) m6A 5'UTR       25456834//24981863
chr17:14205193-14205194(+) m6A CDS       25456834//24981863
chr17:14207180-14207181(+) m6A intron       25456834//24981863//22608085
chr17:14207205-14207206(+) m6A intron       25456834//24981863//22608085
chr17:14207220-14207221(+) m6A intron       25456834//24981863//22608085
chr17:14207225-14207226(+) m6A intron       25456834//24981863//22608085
chr17:14207378-14207379(+) m6A intron       25456834//24981863//22608085
chr17:14207402-14207403(+) m6A intron       25456834//24981863//22608085
chr17:14207478-14207479(+) m6A intron       25456834//24981863//22608085
chr17:14207553-14207554(+) m6A intron       25456834//22608085
chr17:14207566-14207567(+) m6A intron       25456834//22608085
chr17:14207659-14207660(+) m6A intron       25456834//24981863//22608085
chr17:14207674-14207675(+) m6A intron       25456834//22608085
chr17:14208099-14208100(+) m6A intron       22608085
chr17:14208123-14208124(+) m6A intron       22608085
chr17:14208143-14208144(+) m6A intron       22608085
chr17:14208507-14208508(+) m6A intron       25456834//24981863//22608085
chr17:14208595-14208596(+) m6A intron       25456834//24981863//22608085
chr17:14208604-14208605(+) m6A intron       25456834//24981863//22608085
chr17:14208616-14208617(+) m6A intron       25456834//24981863//22608085
chr17:14208651-14208652(+) m6A intron       25456834//24981863//22608085
chr17:14208698-14208699(+) m6A intron       25456834//22608085
chr17:14232560-14232561(+) m6A intron       27773535
chr17:14248727-14248728(+) m6A CDS       24981863
chr17:14248757-14248758(+) m6A CDS       24981863
chr17:14248780-14248781(+) m6A CDS       24981863//22608085
chr17:14248843-14248844(+) m6A CDS       25456834//24981863//22608085
chr17:14248855-14248856(+) m6A CDS       25456834//24981863//22608085
chr17:14248967-14248968(+) m6A 3'UTR       25456834//24981863//22608085
chr17:14251468-14251469(+) m6A 3'UTR       24981863//22608085
chr17:14251521-14251522(+) m6A 3'UTR       24981863//22608085
chr17:14251558-14251559(+) m6A 3'UTR       24981863//22608085
chr17:14251564-14251565(+) m6A 3'UTR       24981863//22608085
chr17:14251605-14251606(+) m6A 3'UTR       24981863//22608085
chr17:14252305-14252306(+) m6A 3'UTR       22608085
chr17:14252364-14252365(+) m6A 3'UTR       24981863//22608085
chr17:14252371-14252372(+) m6A 3'UTR       24981863//22608085
chr17:14252443-14252444(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate HS3ST3B1
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem ID
RNAactDrug ebv-miR-BART1-5p
Panobinostat       6918837
Irinotecan       60838
Topotecan       60700
l-685,458       5479543
Palbociclib       5330286
Dovitinib       135398510
Crizotinib       11626560

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BART1-5p
Interactor2: HS3ST3B1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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