Basic Information:

  VIRBase ID:  

VHID00289702

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8847

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:  MIMAT0000999          TRAF4:  NM_004295     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART1-5p	TRAF4
miRBase Accession/Entrez ID	MIMAT0000999	9618
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CART1//MLN62//RNF83

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRAF4	chr17:27073892(+) A-I      intronic chr17:27072836(+) A-I      intronic chr17:27072866(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRAF4	chr17:27072360-27072361(+) m6A 3'UTR//intron       24284625 chr17:27072405-27072406(+) m6A 3'UTR//intron       24284625 chr17:27074805-27074806(+) m6A exon//intron       24284625 chr17:27074870-27074871(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625 chr17:27075604-27075605(+) m6A 3'UTR//CDS//exon//intron       22575960 chr17:27075625-27075626(+) m6A 3'UTR//CDS//exon//intron       22575960 chr17:27075664-27075665(+) m6A 3'UTR//CDS//exon//intron       24981863//22575960 chr17:27075733-27075734(+) m6A exon//intron       24981863//22575960 chr17:27076381-27076382(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076400-27076401(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076419-27076420(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076512-27076513(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076527-27076528(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076570-27076571(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr17:27076656-27076657(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076674-27076675(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr17:27076784-27076785(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960 chr17:27076813-27076814(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960 chr17:27076855-27076856(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960 chr17:27076887-27076888(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942 chr17:27077153-27077154(+) m6A 3'UTR       24284625//25456834 chr17:27077171-27077172(+) m6A 3'UTR       24284625//25456834 chr17:27077255-27077256(+) m6A 3'UTR       24284625//25456834//24981863 chr17:27077469-27077470(+) m6A 3'UTR       24981863//26404942//22608085 chr17:27077590-27077591(+) m6A 3'UTR       24284625 chr17:27077609-27077610(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TRAF4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART1-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART1-5p
Interactor2: TRAF4

Evidence Support:

Strong-Evidence	Luciferase reporter assay
Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22291592	Target region	CDS
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).