Basic Information:

  VIRBase ID:  

VHID00289621

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:  MIMAT0000999          CPNE3:  NM_003909     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART1-5p	CPNE3
miRBase Accession/Entrez ID	MIMAT0000999	8895
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CPN3//PRO1071

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CPNE3	chr8:87538395(+) A-I      intronic chr8:87545305(+) A-I      intronic chr8:87545303(+) A-I      intronic chr8:87497533(+) A-I      intronic chr8:87552113(+) A-I      intronic chr8:87545309(+) A-I      intronic chr8:87497534(+) A-I      intronic chr8:87497424(+) A-I      intronic chr8:87497520(+) A-I      intronic chr8:87513835(+) A-I      intronic chr8:87513842(+) A-I      intronic chr8:87526141(+) A-I      intronic chr8:87516299(+) A-I      intronic chr8:87516293(+) A-I      intronic chr8:87531998(+) A-I      intronic chr8:87532046(+) A-I      intronic chr8:87532202(+) A-I      intronic chr8:87516263(+) A-I      intronic chr8:87516258(+) A-I      intronic chr8:87532663(+) A-I      intronic chr8:87538359(+) A-I      intronic chr8:87538363(+) A-I      intronic chr8:87538368(+) A-I      intronic chr8:87532108(+) A-I      intronic chr8:87545317(+) A-I      intronic chr8:87545311(+) A-I      intronic chr8:87540256(+) A-I      intronic chr8:87532518(+) A-I      intronic chr8:87532986(+) A-I      intronic chr8:87532517(+) A-I      intronic chr8:87531267(+) A-I      intronic chr8:87531252(+) A-I      intronic chr8:87538336(+) A-I      intronic chr8:87532987(+) A-I      intronic chr8:87532588(+) A-I      intronic chr8:87540277(+) A-I      intronic chr8:87532662(+) A-I      intronic chr8:87531137(+) A-I      intronic chr8:87540276(+) A-I      intronic chr8:87542537(+) A-I      intronic chr8:87533064(+) A-I      intronic chr8:87533012(+) A-I      intronic chr8:87540213(+) A-I      intronic chr8:87532570(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CPNE3	chr8:87531252(+) A-G intron -    22484847 chr8:87531267(+) A-G intron -    22484847 chr8:87532622(+) A-G intron -    22484847 chr8:87532624(+) A-G intron -    22484847 chr8:87532986(+) A-G intron -    22484847 chr8:87532987(+) A-G intron -    22484847 chr8:87533070(+) A-G intron -    22484847 chr8:87533101(+) A-G intron -    22484847 chr8:87540251(+) A-G intron -    22484847 chr8:87540254(+) A-G intron -    22484847 chr8:87540256(+) A-G intron -    22484847 chr8:87540276(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CPNE3	chr8:87516049-87516050(+) m6A intron       27773535//22608085 chr8:87526761-87526762(+) m6A 5'UTR//exon//intron       25456834//24981863 chr8:87568553-87568554(+) m6A CDS//exon       24284625 chr8:87570592-87570593(+) m6A CDS//exon       24284625//24981863//26404942 chr8:87570609-87570610(+) m6A CDS//exon       24284625//24981863//26404942 chr8:87570622-87570623(+) m6A CDS//exon       24284625//24981863//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CPNE3	Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     -

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART1-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART1-5p
Interactor2: CPNE3

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.