Basic Information:

  VIRBase ID:  

VHID00288746

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BART1-5p:  MIMAT0000999          CDK4:  NM_000075     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BART1-5p	CDK4
miRBase Accession/Entrez ID	MIMAT0000999	1019
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CMM3//PSK-J3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDK4	chr12:58144306(-) A-I      intronic chr12:58144164(-) A-I      intronic chr12:58142707(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDK4	chr12:58142491(-) G-A intron -    22484847 chr12:58143571(-) T-C intron -    22484847 chr12:58143593(-) T-C intron -    22484847 chr12:58144164(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDK4	chr12:58141854-58141855(-) m6A 3'UTR       27773535 chr12:58142034-58142035(-) m6A 3'UTR       24284625 chr12:58142039-58142040(-) m6A 3'UTR       24284625 chr12:58142255-58142256(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr12:58142987-58142988(-) Gm 3'UTR//CDS//exon       - chr12:58145029-58145030(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145039-58145040(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145047-58145048(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145053-58145054(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145096-58145097(-) m6A CDS//exon//intron       27773535//22575960 chr12:58145194-58145195(-) m6A exon//intron       27773535 chr12:58145236-58145237(-) m6A exon//intron       27773535 chr12:58145445-58145446(-) m6A 5'UTR//CDS//exon//intron       22575960 chr12:58146013-58146014(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22575960 chr12:58146042-58146043(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CDK4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Related Drug Information:

Resource	Symbol	Drug Name	PubChem ID
RNAactDrug	ebv-miR-BART1-5p	Panobinostat       6918837 Irinotecan       60838 Topotecan       60700 l-685,458       5479543 Palbociclib       5330286 Dovitinib       135398510 Crizotinib       11626560

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BART1-5p
Interactor2: CDK4

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.