Detail Information

Basic Information:


  VIRBase ID:  

VHID00287522

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-3:           ARHGEF2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-3 ARHGEF2
miRBase
Accession/Entrez ID		 MIMAT0000998 9181
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - GEF//GEF-H1//GEFH1//Lfc//LFP40//NEDMHM//P40

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ARHGEF2
chr1:155925986(-) A-I      intronic
chr1:155933315(-) A-I      intronic
chr1:155933319(-) A-I      intronic
chr1:155931396(-) A-I      intronic
chr1:155919271(-) A-I      intronic
chr1:155931242(-) A-I      intronic
chr1:155919826(-) A-I      intronic
chr1:155922890(-) A-I      intronic
chr1:155931237(-) A-I      intronic
chr1:155931233(-) A-I      intronic
chr1:155931206(-) A-I      intronic
chr1:155918733(-) A-I      intronic
chr1:155930177(-) A-I      intronic
chr1:155930141(-) A-I      intronic
chr1:155926424(-) A-I      intronic
chr1:155926365(-) A-I      intronic
chr1:155926185(-) A-I      intronic
chr1:155926117(-) A-I      intronic
chr1:155926109(-) A-I      intronic
chr1:155926038(-) A-I      intronic
chr1:155926028(-) A-I      intronic
chr1:155926005(-) A-I      intronic
chr1:155926001(-) A-I      intronic
chr1:155925996(-) A-I      intronic
chr1:155925639(-) A-I      intronic
chr1:155925612(-) A-I      intronic
chr1:155925604(-) A-I      intronic
chr1:155925054(-) A-I      intronic
chr1:155931240(-) A-I      intronic
chr1:155925053(-) A-I      intronic
chr1:155925040(-) A-I      intronic
chr1:155924171(-) A-I      intronic
chr1:155923457(-) A-I      intronic
chr1:155923370(-) A-I      intronic
chr1:155923361(-) A-I      intronic
chr1:155922999(-) A-I      intronic
chr1:155922974(-) A-I      intronic
chr1:155922894(-) A-I      intronic
chr1:155931268(-) A-I      intronic
chr1:155922884(-) A-I      intronic
chr1:155933325(-) A-I      intronic
chr1:155933330(-) A-I      intronic
chr1:155922830(-) A-I      intronic
chr1:155933334(-) A-I      intronic
chr1:155933743(-) A-I      intronic
chr1:155934467(-) A-I      intronic
chr1:155934476(-) A-I      intronic
chr1:155925766(-) A-I      intronic
chr1:155934489(-) A-I      intronic
chr1:155934499(-) A-I      intronic
chr1:155943450(-) A-I      intronic
chr1:155943535(-) A-I      intronic
chr1:155943904(-) A-I      intronic
chr1:155918919(-) A-I      intronic
chr1:155919103(-) A-I      intronic
chr1:155942503(-) A-I      intronic
chr1:155926179(-) A-I      intronic
chr1:155918278(-) A-I      intronic
chr1:155943274(-) A-I      intronic
chr1:155925026(-) A-I      intronic
chr1:155934670(-) A-I      intronic
chr1:155918535(-) A-I      intronic
chr1:155941284(-) A-I      intronic
chr1:155943923(-) A-I      intronic
chr1:155926492(-) A-I      intronic
chr1:155930021(-) A-I      intronic
chr1:155926770(-) A-I      intronic
chr1:155941672(-) A-I      intronic
chr1:155925987(-) A-I      intronic
chr1:155930063(-) A-I      intronic
chr1:155930087(-) A-I      intronic
chr1:155923051(-) A-I      intronic
chr1:155925995(-) A-I      intronic
chr1:155923450(-) A-I      intronic
chr1:155926603(-) A-I      intronic
chr1:155919499(-) A-I      intronic
chr1:155930160(-) A-I      intronic
chr1:155942763(-) A-I      intronic
chr1:155918241(-) A-I      intronic
chr1:155943286(-) A-I      intronic
chr1:155941308(-) A-I      intronic
chr1:155928488(-) A-I      intronic
chr1:155926504(-) A-I      intronic
chr1:155930136(-) A-I      intronic
chr1:155925700(-) A-I      intronic
chr1:155925609(-) A-I      intronic
chr1:155934092(-) A-I      intronic
chr1:155933603(-) A-I      intronic
chr1:155926421(-) A-I      intronic
chr1:155923958(-) A-I      intronic
chr1:155922934(-) A-I      intronic
chr1:155926584(-) A-I      intronic
chr1:155926818(-) A-I      intronic
chr1:155925018(-) A-I      intronic
chr1:155925537(-) A-I      intronic
chr1:155934073(-) A-I      intronic
chr1:155918561(-) A-I      intronic
chr1:155942790(-) A-I      intronic
chr1:155933601(-) A-I      intronic
chr1:155922993(-) A-I      intronic
chr1:155926072(-) A-I      intronic
chr1:155923891(-) A-I      intronic
chr1:155942768(-) A-I      intronic
chr1:155924000(-) A-I      intronic
chr1:155926054(-) A-I      intronic
chr1:155943928(-) A-I      intronic
chr1:155930138(-) A-I      intronic
chr1:155931337(-) A-I      intronic
chr1:155934109(-) A-I      intronic
chr1:155943292(-) A-I      intronic
chr1:155924164(-) A-I      intronic
chr1:155923421(-) A-I      intronic
chr1:155926783(-) A-I      intronic
chr1:155926069(-) A-I      intronic
chr1:155934086(-) A-I      intronic
chr1:155925592(-) A-I      intronic
chr1:155919803(-) A-I      intronic
chr1:155943345(-) A-I      intronic
chr1:155933889(-) A-I      intronic
chr1:155926068(-) A-I      intronic
chr1:155942775(-) A-I      intronic
chr1:155926625(-) A-I      intronic
chr1:155942769(-) A-I      intronic
chr1:155943354(-) A-I      intronic
chr1:155919804(-) A-I      intronic
chr1:155918718(-) A-I      intronic
chr1:155942694(-) A-I      intronic
chr1:155933560(-) A-I      intronic
chr1:155923532(-) A-I      intronic
chr1:155942601(-) A-I      intronic
chr1:155926769(-) A-I      intronic
chr1:155922790(-) A-I      intronic
chr1:155923411(-) A-I      intronic
chr1:155928505(-) A-I      intronic
chr1:155925778(-) A-I      intronic
chr1:155926063(-) A-I      intronic
chr1:155922944(-) A-I      intronic
chr1:155943876(-) A-I      intronic
chr1:155928539(-) A-I      intronic
chr1:155929107(-) A-I      intronic
chr1:155942565(-) A-I      intronic
chr1:155926505(-) A-I      intronic
chr1:155926027(-) A-I      intronic
chr1:155926555(-) A-I      intronic
chr1:155933555(-) A-I      intronic
chr1:155926430(-) A-I      intronic
chr1:155933229(-) A-I      intronic
chr1:155943280(-) A-I      intronic
chr1:155943968(-) A-I      intronic
chr1:155929221(-) A-I      intronic
chr1:155925772(-) A-I      intronic
chr1:155926456(-) A-I      intronic
chr1:155945439(-) A-I      intronic
chr1:155930207(-) A-I      intronic
chr1:155923425(-) A-I      intronic
chr1:155942771(-) A-I      intronic
chr1:155934108(-) A-I      intronic
chr1:155930105(-) A-I      intronic
chr1:155934608(-) A-I      intronic
chr1:155925596(-) A-I      intronic
chr1:155926148(-) A-I      intronic
chr1:155926744(-) A-I      intronic
chr1:155930147(-) A-I      intronic
chr1:155919295(-) A-I      intronic
chr1:155925671(-) A-I      intronic
chr1:155930077(-) A-I      intronic
chr1:155924991(-) A-I      intronic
chr1:155929290(-) A-I      intronic
chr1:155919413(-) A-I      intronic
chr1:155925037(-) A-I      intronic
chr1:155930038(-) A-I      intronic
chr1:155941595(-) A-I      intronic
chr1:155943332(-) A-I      intronic
chr1:155934111(-) A-I      intronic
chr1:155929216(-) A-I      intronic
chr1:155926369(-) A-I      intronic
chr1:155926349(-) A-I      intronic
chr1:155919834(-) A-I      intronic
chr1:155918523(-) A-I      intronic
chr1:155930148(-) A-I      intronic
chr1:155926083(-) A-I      intronic
chr1:155926420(-) A-I      intronic
chr1:155943944(-) A-I      intronic
chr1:155918522(-) A-I      intronic
chr1:155943927(-) A-I      intronic
chr1:155930253(-) A-I      intronic
chr1:155943933(-) A-I      intronic
chr1:155930197(-) A-I      intronic
chr1:155918678(-) A-I      intronic
chr1:155934044(-) A-I      intronic
chr1:155930094(-) A-I      intronic
chr1:155943437(-) A-I      intronic
chr1:155933261(-) A-I      intronic
chr1:155926163(-) A-I      intronic
chr1:155926581(-) A-I      intronic
chr1:155929457(-) A-I      intronic
chr1:155942595(-) A-I      intronic
chr1:155919128(-) A-I      intronic
chr1:155926162(-) A-I      intronic
chr1:155926010(-) A-I      intronic
chr1:155918737(-) A-I      intronic
chr1:155930151(-) A-I      intronic
chr1:155928434(-) A-I      intronic
chr1:155930088(-) A-I      intronic
chr1:155942741(-) A-I      intronic
chr1:155929530(-) A-I      intronic
chr1:155923424(-) A-I      intronic
chr1:155925645(-) A-I      intronic
chr1:155930011(-) A-I      intronic
chr1:155941594(-) A-I      intronic
chr1:155919819(-) A-I      intronic
chr1:155926355(-) A-I      intronic
chr1:155926367(-) A-I      intronic
chr1:155925667(-) A-I      intronic
chr1:155943451(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ARHGEF2
chr1:155917088(-) A-I exon 3'UTR    22327324
chr1:155925609(-) A-I intron -    22327324
chr1:155919499(-) A-G intron -    22484847
chr1:155922934(-) A-G intron -    22484847
chr1:155922993(-) A-G intron -    22484847
chr1:155923421(-) A-G intron -    22484847
chr1:155923424(-) A-G intron -    22484847
chr1:155923425(-) A-G intron -    22484847
chr1:155925587(-) T-C intron -    22484847
chr1:155925609(-) A-G intron -    22484847
chr1:155925987(-) A-G intron -    22484847
chr1:155926010(-) A-G intron -    22484847
chr1:155926027(-) A-G intron -    22484847
chr1:155926054(-) A-G intron -    22484847
chr1:155926063(-) A-G intron -    22484847
chr1:155926068(-) A-G intron -    22484847
chr1:155926069(-) A-G intron -    22484847
chr1:155926072(-) A-G intron -    22484847
chr1:155926083(-) A-G intron -    22484847
chr1:155926162(-) A-G intron -    22484847
chr1:155926163(-) A-G intron -    22484847
chr1:155926179(-) A-G intron -    22484847
chr1:155926355(-) A-G intron -    22484847
chr1:155926421(-) A-G intron -    22484847
chr1:155926430(-) A-G intron -    22484847
chr1:155926492(-) A-G intron -    22484847
chr1:155926555(-) A-G intron -    22484847
chr1:155926581(-) A-G intron -    22484847
chr1:155926603(-) A-G intron -    22484847
chr1:155926625(-) A-G intron -    22484847
chr1:155926744(-) A-G intron -    22484847
chr1:155926769(-) A-G intron -    22484847
chr1:155926770(-) A-G intron -    22484847
chr1:155926828(-) A-T intron -    22484847
chr1:155926830(-) T-A intron -    22484847
chr1:155930011(-) A-G intron -    22484847
chr1:155930021(-) A-G intron -    22484847
chr1:155930063(-) A-G intron -    22484847
chr1:155930087(-) A-G intron -    22484847
chr1:155930088(-) A-G intron -    22484847
chr1:155930094(-) A-G intron -    22484847
chr1:155930136(-) A-G intron -    22484847
chr1:155930147(-) A-G intron -    22484847
chr1:155930148(-) A-G intron -    22484847
chr1:155930160(-) A-G intron -    22484847
chr1:155930197(-) A-G intron -    22484847
chr1:155930207(-) A-G intron -    22484847
chr1:155930253(-) A-G intron -    22484847
chr1:155933555(-) A-G intron -    22484847
chr1:155934111(-) A-G intron -    22484847
chr1:155934701(-) C-T intron -    22484847
chr1:155942694(-) A-G intron -    22484847
chr1:155942763(-) A-G intron -    22484847
chr1:155943274(-) A-G intron -    22484847
chr1:155943286(-) A-G intron -    22484847
chr1:155943345(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ARHGEF2
chr1:155916752-155916753(-) m6A 3'UTR//exon       27773535
chr1:155916786-155916787(-) m6A 3'UTR//exon       27773535
chr1:155916860-155916861(-) m6A 3'UTR//exon       27773535
chr1:155916893-155916894(-) m6A 3'UTR//intron       27773535
chr1:155917071-155917072(-) m6A 3'UTR//intron       27773535
chr1:155917081-155917082(-) m6A 3'UTR//intron       27773535
chr1:155917376-155917377(-) m6A 3'UTR//intron       26404942//27773535
chr1:155917411-155917412(-) m6A 3'UTR//intron       26404942//27773535
chr1:155917419-155917420(-) m6A 3'UTR//intron       26404942//27773535
chr1:155917426-155917427(-) m6A 3'UTR//intron       26404942//27773535
chr1:155917540-155917541(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:155917630-155917631(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:155917642-155917643(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:155917667-155917668(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:155917694-155917695(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr1:155917776-155917777(-) Gm 3'UTR//CDS//intron       -
chr1:155917787-155917788(-) m6A 3'UTR//CDS//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr1:155920065-155920066(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chr1:155920071-155920072(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960
chr1:155920083-155920084(-) m6A CDS//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr1:155920160-155920161(-) m6A 3'UTR//CDS//intron       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr1:155920189-155920190(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//27371828//27773536//22575960
chr1:155920205-155920206(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//27371828//27773536
chr1:155920214-155920215(-) m6A 3'UTR//CDS//intron       24284625//24981863//27773535//27371828//27773536
chr1:155920688-155920689(-) m6A CDS//intron       24284625//24981863//27371828//27773536
chr1:155920726-155920727(-) m6A CDS//intron       28052920//27371828//27773536
chr1:155920913-155920914(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828//27773536//22575960
chr1:155921043-155921044(-) m6A CDS//intron       24209618//25456834//27371828//22575960
chr1:155921291-155921292(-) m6A CDS//intron       25456834//27371828//22575960
chr1:155921722-155921723(-) m6A CDS//intron       27371828
chr1:155921742-155921743(-) m6A CDS//intron       27371828
chr1:155921762-155921763(-) m6A CDS//intron       27371828
chr1:155921941-155921942(-) m6A CDS//intron       27371828
chr1:155921946-155921947(-) m6A CDS//intron       27371828
chr1:155921985-155921986(-) m6A CDS//intron       27371828
chr1:155922010-155922011(-) m6A CDS//intron       27371828
chr1:155922600-155922601(-) m6A CDS//exon//intron       27773535//27371828
chr1:155924725-155924726(-) m6A CDS//exon//intron       27773535//27371828
chr1:155924742-155924743(-) m6A CDS//exon//intron       27773535//27371828
chr1:155932763-155932764(-) m6A CDS//intron       27773535
chr1:155932941-155932942(-) m6A 3'UTR//CDS//intron       27773535
chr1:155932962-155932963(-) m6A 3'UTR//CDS//intron       27773535
chr1:155936244-155936245(-) m6A CDS//exon//intron       27773535
chr1:155936644-155936645(-) m6A CDS//exon//intron       27773535
chr1:155938096-155938097(-) m6A exon//intron       27773535
chr1:155938109-155938110(-) m6A exon//intron       27773535
chr1:155938122-155938123(-) m6A exon//intron       27773535
chr1:155938932-155938933(-) m6A exon//intron       27773535
chr1:155939378-155939379(-) m6A 5'UTR//intron       24284625//24981863//27773535//27371828//27773536
chr1:155939923-155939924(-) m6A exon//intron       27773535
chr1:155939951-155939952(-) m6A exon//intron       27773535
chr1:155939970-155939971(-) m6A exon//intron       27773535//27371828
chr1:155940067-155940068(-) m6A exon//intron       27773535//27371828
chr1:155940644-155940645(-) m6A exon//intron       24284625//27371828
chr1:155940658-155940659(-) m6A exon//intron       24284625//27371828
chr1:155940673-155940674(-) m6A exon//intron       24284625//27371828
chr1:155940747-155940748(-) m6A exon//intron       25456834//24981863//27773535//27371828
chr1:155940765-155940766(-) m6A exon//intron       25456834//24981863//28052920//27773535//27371828
chr1:155940786-155940787(-) m6A exon//intron       25456834//24981863//28052920//27773535//27371828
chr1:155940847-155940848(-) m6A exon//intron       25456834//27773535//27371828
chr1:155941977-155941978(-) Gm intron       -
chr1:155947894-155947895(-) m6A 5'UTR//intron       -
chr1:155947925-155947926(-) m6A 5'UTR//intron       -
chr1:155948295-155948296(-) m6A 5'UTR//intron       24284625//24981863//27371828
chr1:155948314-155948315(-) m6A 5'UTR//intron       24284625//24981863//27371828
chr1:155948708-155948709(-) m6A 5'UTR//exon//intron       24284625//24981863//27371828
chr1:155948772-155948773(-) m6A 5'UTR//exon//intron       27371828
chr1:155948792-155948793(-) m6A 5'UTR//exon//intron       27371828
chr1:155952935-155952936(-) m6A CDS//intron       -
chr1:155952972-155952973(-) m6A CDS//intron       27773535
chr1:155955139-155955140(-) m6A CDS//intron       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ARHGEF2
Chromatin HeLa-S3 cells|K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Insoluble cytoplasm K562 cells     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-3
Interactor2: ARHGEF2

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase//VIRmiRNA

References:


PMID 22291592 Target region CDS
Source ViRBase//VIRmiRNA Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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