Detail Information

Basic Information:


  VIRBase ID:  

VHID00287353

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-3:           RAP2A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-3 RAP2A
miRBase
Accession/Entrez ID		 MIMAT0000998 5911
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - K-REV//KREV//RAP2//RbBP-30

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RAP2A
chr13:98114096(+) A-I      intronic
chr13:98114124(+) A-I      intronic
chr13:98115948(+) A-I      intronic
chr13:98115943(+) A-I      intronic
chr13:98115944(+) A-I      intronic
chr13:98115937(+) A-I      intronic
chr13:98115989(+) A-I      intronic
chr13:98113962(+) A-I      intronic
chr13:98115973(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RAP2A
chr13:98115937(+) A-G intron -    22484847
chr13:98115944(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RAP2A
chr13:98086836-98086837(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr13:98086893-98086894(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr13:98086929-98086930(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr13:98086998-98086999(+) m6A CDS       24284625//24209618//25456834//22575960//22608085
chr13:98087016-98087017(+) m6A CDS       24284625//25456834//22575960//22608085
chr13:98094091-98094092(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr13:98094099-98094100(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr13:98116490-98116491(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr13:98116499-98116500(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr13:98116576-98116577(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr13:98116594-98116595(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr13:98116608-98116609(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr13:98116637-98116638(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr13:98116751-98116752(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr13:98116772-98116773(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr13:98116805-98116806(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr13:98117038-98117039(+) m6A 3'UTR       24284625//24981863//22608085
chr13:98117298-98117299(+) m6A 3'UTR       24284625//24981863//22608085
chr13:98117331-98117332(+) m6A 3'UTR       24284625//24981863//22608085
chr13:98117338-98117339(+) m6A 3'UTR       24284625//22608085
chr13:98117437-98117438(+) m6A 3'UTR       22608085
chr13:98117444-98117445(+) m6A 3'UTR       22608085
chr13:98117484-98117485(+) m6A 3'UTR       22608085
chr13:98119034-98119035(+) Y 3'UTR       26075521

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate RAP2A
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleus K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-3
Interactor2: RAP2A

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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