Basic Information:

  VIRBase ID:  

VHID00285099

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-3p:  MIMAT0000997          HCFC2:  NM_013320     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-3p	HCFC2
miRBase Accession/Entrez ID	MIMAT0000997	29915
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCF-2//HCF2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HCFC2	chr12:104471978(+) A-I      intronic chr12:104471986(+) A-I      intronic chr12:104466629(+) A-I      intronic chr12:104493709(+) A-I      intronic chr12:104493583(+) A-I      intronic chr12:104468855(+) A-I      intronic chr12:104465435(+) A-I      intronic chr12:104493353(+) A-I      intronic chr12:104471926(+) A-I      intronic chr12:104493258(+) A-I      intronic chr12:104468877(+) A-I      intronic chr12:104465388(+) A-I      intronic chr12:104493236(+) A-I      intronic chr12:104493370(+) A-I      intronic chr12:104493644(+) A-I      intronic chr12:104477681(+) A-I      intronic chr12:104493635(+) A-I      intronic chr12:104493632(+) A-I      intronic chr12:104477679(+) A-I      intronic chr12:104494081(+) A-I      intronic chr12:104465896(+) A-I      intronic chr12:104465895(+) A-I      intronic chr12:104494286(+) A-I      intronic chr12:104471919(+) A-I      intronic chr12:104468904(+) A-I      intronic chr12:104493250(+) A-I      intronic chr12:104467970(+) A-I      intronic chr12:104493467(+) A-I      intronic chr12:104493618(+) A-I      intronic chr12:104494120(+) A-I      intronic chr12:104494161(+) A-I      intronic chr12:104493377(+) A-I      intronic chr12:104465429(+) A-I      intronic chr12:104477708(+) A-I      intronic chr12:104494087(+) A-I      intronic chr12:104495112(+) A-I      intronic chr12:104466684(+) A-I      intronic chr12:104493488(+) A-I      intronic chr12:104465995(+) A-I      intronic chr12:104465946(+) A-I      intronic chr12:104468875(+) A-I      intronic chr12:104466099(+) A-I      intronic chr12:104493655(+) A-I      intronic chr12:104466089(+) A-I      intronic chr12:104494998(+) A-I      intronic chr12:104469370(+) A-I      intronic chr12:104465389(+) A-I      intronic chr12:104493548(+) A-I      intronic chr12:104493518(+) A-I      intronic chr12:104464604(+) A-I      intronic chr12:104479869(+) A-I      intronic chr12:104477622(+) A-I      intronic chr12:104494126(+) A-I      intronic chr12:104494147(+) A-I      intronic chr12:104477655(+) A-I      intronic chr12:104467203(+) A-I      intronic chr12:104463004(+) A-I      intronic chr12:104471972(+) A-I      intronic chr12:104493523(+) A-I      intronic chr12:104466013(+) A-I      intronic chr12:104493577(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HCFC2	chr12:104493577(+) A-I intron -    22327324 chr12:104493583(+) A-I intron -    22327324 chr12:104493518(+) A-G intron -    22484847 chr12:104493577(+) A-G intron -    22484847 chr12:104493583(+) A-G intron -    22484847 chr12:104465388(+) A-G intron -    22484847 chr12:104465435(+) A-G intron -    22484847 chr12:104465946(+) A-G intron -    22484847 chr12:104468875(+) A-G intron -    22484847 chr12:104493250(+) A-G intron -    22484847 chr12:104493655(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HCFC2	chr12:104458412-104458413(+) m6A CDS       - chr12:104496765-104496766(+) m6A 3'UTR//CDS//exon       24284625//22608085 chr12:104496886-104496887(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:104496993-104496994(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr12:104497160-104497161(+) m6A 3'UTR//exon       24981863 chr12:104497232-104497233(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-3p	Exosome K562 cells     24460325
	HCFC2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-3p
Interactor2: HCFC2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).