Basic Information:

  VIRBase ID:  

VHID00284315

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-3p:  MIMAT0000997          HERC3:  NM_001271602     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-3p	HERC3
miRBase Accession/Entrez ID	MIMAT0000997	8916
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HERC3	chr4:89543982(+) A-I      intronic chr4:89610472(+) A-I      intronic chr4:89523350(+) A-I      intronic chr4:89610859(+) A-I      intronic chr4:89610449(+) A-I      intronic chr4:89610477(+) A-I      intronic chr4:89610384(+) A-I      intronic chr4:89523513(+) A-I      intronic chr4:89523851(+) A-I      intronic chr4:89547474(+) A-I      intronic chr4:89547450(+) A-I      intronic chr4:89628436(+) A-I      3'UTR chr4:89610470(+) A-I      intronic chr4:89523899(+) A-I      intronic chr4:89523828(+) A-I      intronic chr4:89515629(+) A-I      intronic chr4:89610590(+) A-I      intronic chr4:89626192(+) A-I      intronic chr4:89610929(+) A-I      intronic chr4:89548799(+) A-I      intronic chr4:89610454(+) A-I      intronic chr4:89610585(+) A-I      intronic chr4:89530184(+) A-I      intronic chr4:89610400(+) A-I      intronic chr4:89523703(+) A-I      intronic chr4:89610909(+) A-I      intronic chr4:89515667(+) A-I      intronic chr4:89531394(+) A-I      intronic chr4:89515694(+) A-I      intronic chr4:89515680(+) A-I      intronic chr4:89531483(+) A-I      intronic chr4:89531368(+) A-I      intronic chr4:89523821(+) A-I      intronic chr4:89610870(+) A-I      intronic chr4:89548983(+) A-I      intronic chr4:89610474(+) A-I      intronic chr4:89531351(+) A-I      intronic chr4:89610862(+) A-I      intronic chr4:89610563(+) A-I      intronic chr4:89523687(+) A-I      intronic chr4:89528708(+) A-I      intronic chr4:89610938(+) A-I      intronic chr4:89610521(+) A-I      intronic chr4:89527520(+) A-I      intronic chr4:89523893(+) A-I      intronic chr4:89516132(+) A-I      intronic chr4:89610809(+) A-I      intronic chr4:89611003(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HERC3	chr4:89610474(+) A-I intron -    21960545 chr4:89527477(+) A-G intron -    22484847 chr4:89610454(+) A-G intron -    22484847 chr4:89610474(+) A-G intron -    22484847 chr4:89610585(+) A-G intron -    22484847 chr4:89610590(+) A-G intron -    22484847 chr4:89610614(+) A-G intron -    22484847 chr4:89610809(+) A-G intron -    22484847 chr4:89610862(+) A-G intron -    22484847 chr4:89610870(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HERC3	chr4:89442487-89442488(+) m6A exon       24284625 chr4:89442542-89442543(+) m6A exon       24284625//27773535 chr4:89442553-89442554(+) m6A exon       24284625//27773535 chr4:89442641-89442642(+) m6A exon       24284625//24209618//24981863//27773535//22608085 chr4:89442879-89442880(+) m6A exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr4:89442896-89442897(+) m6A exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr4:89442911-89442912(+) m6A exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr4:89442930-89442931(+) m6A exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr4:89442936-89442937(+) m6A exon       24284625//24209618//24981863//27773535//22575960//22608085 chr4:89443037-89443038(+) m6A exon       24981863//27773535 chr4:89444682-89444683(+) m6A exon       27773535//27773536 chr4:89444867-89444868(+) m6A exon       25456834//24981863//27371828//27773536 chr4:89513659-89513660(+) m6A 5'UTR//intron       24981863 chr4:89527104-89527105(+) m6A CDS       - chr4:89527155-89527156(+) m6A CDS       - chr4:89527191-89527192(+) m6A CDS       - chr4:89601351-89601352(+) Y CDS       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-3p	Exosome K562 cells     24460325
	HERC3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-3p
Interactor2: HERC3

Evidence Support:

Prediction-Evidence	miRanda//Targetscan
Support Database	VmiReg