Basic Information:

  VIRBase ID:  

VHID00283823

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-3p:  MIMAT0000997          PIP4K2A:  NM_001330062     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-3p	PIP4K2A
miRBase Accession/Entrez ID	MIMAT0000997	5305
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PI5P4KA//PIP5K2A//PIP5KII-alpha//PIP5KIIA//PIPK

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIP4K2A	chr10:22948504(-) A-I      intronic chr10:22851948(-) A-I      intronic chr10:22851949(-) A-I      intronic chr10:22835409(-) A-I      intronic chr10:22851950(-) A-I      intronic chr10:22859255(-) A-I      intronic chr10:22978596(-) A-I      intronic chr10:22835433(-) A-I      intronic chr10:22945008(-) A-I      intronic chr10:22945040(-) A-I      intronic chr10:22851221(-) A-I      intronic chr10:22835424(-) A-I      intronic chr10:22835432(-) A-I      intronic chr10:22887082(-) A-I      intronic chr10:22883457(-) A-I      intronic chr10:22948625(-) A-I      intronic chr10:22883408(-) A-I      intronic chr10:22883397(-) A-I      intronic chr10:22883390(-) A-I      intronic chr10:22887163(-) A-I      intronic chr10:22986483(-) A-I      intronic chr10:22948528(-) A-I      intronic chr10:22948542(-) A-I      intronic chr10:22835417(-) A-I      intronic chr10:22835466(-) A-I      intronic chr10:22948543(-) A-I      intronic chr10:22948536(-) A-I      intronic chr10:22948535(-) A-I      intronic chr10:22851963(-) A-I      intronic chr10:22835461(-) A-I      intronic chr10:22851877(-) A-I      intronic chr10:22851944(-) A-I      intronic chr10:22996040(-) A-I      intronic chr10:22997876(-) A-I      intronic chr10:22851426(-) A-I      intronic chr10:22959213(-) A-I      intronic chr10:22883430(-) A-I      intronic chr10:22835500(-) A-I      intronic chr10:22997884(-) A-I      intronic chr10:22835499(-) A-I      intronic chr10:22887036(-) A-I      intronic chr10:22850732(-) A-I      intronic chr10:22835413(-) A-I      intronic chr10:22835403(-) A-I      intronic chr10:22997926(-) A-I      intronic chr10:22997959(-) A-I      intronic chr10:22851421(-) A-I      intronic chr10:22942009(-) A-I      intronic chr10:22850656(-) A-I      intronic chr10:22939282(-) A-I      intronic chr10:22941114(-) A-I      intronic chr10:22883543(-) A-I      intronic chr10:22997804(-) A-I      intronic chr10:22941180(-) A-I      intronic chr10:22954446(-) A-I      intronic chr10:22970573(-) A-I      intronic chr10:22850648(-) A-I      intronic chr10:22934283(-) A-I      intronic chr10:22977449(-) A-I      intronic chr10:22995994(-) A-I      intronic chr10:22884577(-) A-I      intronic chr10:22950354(-) A-I      intronic chr10:22956977(-) A-I      intronic chr10:22986544(-) A-I      intronic chr10:22850567(-) A-I      intronic chr10:22941856(-) A-I      intronic chr10:22948689(-) A-I      intronic chr10:22941801(-) A-I      intronic chr10:22934392(-) A-I      intronic chr10:22887217(-) A-I      intronic chr10:22851432(-) A-I      intronic chr10:22986542(-) A-I      intronic chr10:22835612(-) A-I      intronic chr10:22900211(-) A-I      intronic chr10:22986428(-) A-I      intronic chr10:22884578(-) A-I      intronic chr10:22950571(-) A-I      intronic chr10:22986400(-) A-I      intronic chr10:22934303(-) A-I      intronic chr10:22950321(-) A-I      intronic chr10:22891753(-) A-I      intronic chr10:22887115(-) A-I      intronic chr10:22887131(-) A-I      intronic chr10:22957152(-) A-I      intronic chr10:22837757(-) A-I      intronic chr10:22941985(-) A-I      intronic chr10:22941936(-) A-I      intronic chr10:22986372(-) A-I      intronic chr10:22977578(-) A-I      intronic chr10:22942746(-) A-I      intronic chr10:22851353(-) A-I      intronic chr10:22941906(-) A-I      intronic chr10:22942789(-) A-I      intronic chr10:22851288(-) A-I      intronic chr10:22900267(-) A-I      intronic chr10:22941831(-) A-I      intronic chr10:22941815(-) A-I      intronic chr10:22941306(-) A-I      intronic chr10:22887237(-) A-I      intronic chr10:22941196(-) A-I      intronic chr10:22959111(-) A-I      intronic chr10:22908530(-) A-I      intronic chr10:22997917(-) A-I      intronic chr10:22887240(-) A-I      intronic chr10:22851369(-) A-I      intronic chr10:22897566(-) A-I      intronic chr10:22884546(-) A-I      intronic chr10:22941296(-) A-I      intronic chr10:22883601(-) A-I      intronic chr10:22851343(-) A-I      intronic chr10:22897706(-) A-I      intronic chr10:22837827(-) A-I      intronic chr10:22941190(-) A-I      intronic chr10:22904276(-) A-I      intronic chr10:22904284(-) A-I      intronic chr10:22934418(-) A-I      intronic chr10:22934680(-) A-I      intronic chr10:22850786(-) A-I      intronic chr10:22941077(-) A-I      intronic chr10:22941163(-) A-I      intronic chr10:22850713(-) A-I      intronic chr10:22986603(-) A-I      intronic chr10:22963840(-) A-I      intronic chr10:22977545(-) A-I      intronic chr10:22884494(-) A-I      intronic chr10:22884523(-) A-I      intronic chr10:22975690(-) A-I      intronic chr10:22957160(-) A-I      intronic chr10:22884468(-) A-I      intronic chr10:22950564(-) A-I      intronic chr10:22949231(-) A-I      intronic chr10:22963865(-) A-I      intronic chr10:22948613(-) A-I      intronic chr10:22851296(-) A-I      intronic chr10:22950410(-) A-I      intronic chr10:22948661(-) A-I      intronic chr10:22954434(-) A-I      intronic chr10:22975482(-) A-I      intronic chr10:22851284(-) A-I      intronic chr10:22887104(-) A-I      intronic chr10:22949183(-) A-I      intronic chr10:22949208(-) A-I      intronic chr10:22949234(-) A-I      intronic chr10:22950316(-) A-I      intronic chr10:22884610(-) A-I      intronic chr10:22883552(-) A-I      intronic chr10:22850562(-) A-I      intronic chr10:22941243(-) A-I      intronic chr10:22950388(-) A-I      intronic chr10:22887241(-) A-I      intronic chr10:22883518(-) A-I      intronic chr10:22975504(-) A-I      intronic chr10:22950493(-) A-I      intronic chr10:22883449(-) A-I      intronic chr10:22950519(-) A-I      intronic chr10:22975490(-) A-I      intronic chr10:22950568(-) A-I      intronic chr10:22883427(-) A-I      intronic chr10:22954581(-) A-I      intronic chr10:22887095(-) A-I      intronic chr10:22964332(-) A-I      intronic chr10:22954595(-) A-I      intronic chr10:22954608(-) A-I      intronic chr10:22883422(-) A-I      intronic chr10:22883417(-) A-I      intronic chr10:22883393(-) A-I      intronic chr10:22954609(-) A-I      intronic chr10:22883385(-) A-I      intronic chr10:22956978(-) A-I      intronic chr10:22941911(-) A-I      intronic chr10:22941253(-) A-I      intronic chr10:22957005(-) A-I      intronic chr10:22957029(-) A-I      intronic chr10:22868738(-) A-I      intronic chr10:22850681(-) A-I      intronic chr10:22941274(-) A-I      intronic chr10:22959125(-) A-I      intronic chr10:22851452(-) A-I      intronic chr10:22975503(-) A-I      intronic chr10:22949386(-) A-I      intronic chr10:22996009(-) A-I      intronic chr10:22957021(-) A-I      intronic chr10:22835586(-) A-I      intronic chr10:22835573(-) A-I      intronic chr10:22950551(-) A-I      intronic chr10:22837930(-) A-I      intronic chr10:22850768(-) A-I      intronic chr10:22996027(-) A-I      intronic chr10:22954606(-) A-I      intronic chr10:22869331(-) A-I      intronic chr10:22950492(-) A-I      intronic chr10:22986572(-) A-I      intronic chr10:22950565(-) A-I      intronic chr10:22887084(-) A-I      intronic chr10:22950559(-) A-I      intronic chr10:22941322(-) A-I      intronic chr10:22948337(-) A-I      intronic chr10:22925391(-) A-I      intronic chr10:22970598(-) A-I      intronic chr10:22883442(-) A-I      intronic chr10:22974598(-) A-I      intronic chr10:22868781(-) A-I      intronic chr10:22950383(-) A-I      intronic chr10:22942756(-) A-I      intronic chr10:22883519(-) A-I      intronic chr10:22883492(-) A-I      intronic chr10:22949317(-) A-I      intronic chr10:22954509(-) A-I      intronic chr10:22949155(-) A-I      intronic chr10:22837901(-) A-I      intronic chr10:22992286(-) A-I      intronic chr10:22934254(-) A-I      intronic chr10:22934722(-) A-I      intronic chr10:22975672(-) A-I      intronic chr10:22986595(-) A-I      intronic chr10:22941329(-) A-I      intronic chr10:22992226(-) A-I      intronic chr10:22934353(-) A-I      intronic chr10:22883489(-) A-I      intronic chr10:22977619(-) A-I      intronic chr10:22963686(-) A-I      intronic chr10:22950449(-) A-I      intronic chr10:22934754(-) A-I      intronic chr10:22974582(-) A-I      intronic chr10:22934253(-) A-I      intronic chr10:22835505(-) A-I      intronic chr10:22986573(-) A-I      intronic chr10:22883453(-) A-I      intronic chr10:22957032(-) A-I      intronic chr10:22934412(-) A-I      intronic chr10:22954482(-) A-I      intronic chr10:22949149(-) A-I      intronic chr10:22948654(-) A-I      intronic chr10:22934258(-) A-I      intronic chr10:22837861(-) A-I      intronic chr10:22934930(-) A-I      intronic chr10:22939293(-) A-I      intronic chr10:22891752(-) A-I      intronic chr10:22934282(-) A-I      intronic chr10:22835555(-) A-I      intronic chr10:22948615(-) A-I      intronic chr10:22964335(-) A-I      intronic chr10:22975674(-) A-I      intronic chr10:22850601(-) A-I      intronic chr10:22942617(-) A-I      intronic chr10:22835469(-) A-I      intronic chr10:22950491(-) A-I      intronic chr10:22870945(-) A-I      intronic chr10:22974531(-) A-I      intronic chr10:22975471(-) A-I      intronic chr10:22997850(-) A-I      intronic chr10:22977546(-) A-I      intronic chr10:22975630(-) A-I      intronic chr10:22954502(-) A-I      intronic chr10:22850636(-) A-I      intronic chr10:22941109(-) A-I      intronic chr10:22941218(-) A-I      intronic chr10:22950538(-) A-I      intronic chr10:22835455(-) A-I      intronic chr10:22864785(-) A-I      intronic chr10:22875624(-) A-I      intronic chr10:22934272(-) A-I      intronic chr10:22883481(-) A-I      intronic chr10:22948374(-) A-I      intronic chr10:22941928(-) A-I      intronic chr10:22941835(-) A-I      intronic chr10:22884574(-) A-I      intronic chr10:22883580(-) A-I      intronic chr10:22957063(-) A-I      intronic chr10:22887243(-) A-I      intronic chr10:22850577(-) A-I      intronic chr10:22977479(-) A-I      intronic chr10:22851354(-) A-I      intronic chr10:22883440(-) A-I      intronic chr10:22948339(-) A-I      intronic chr10:22959199(-) A-I      intronic chr10:22850699(-) A-I      intronic chr10:22941982(-) A-I      intronic chr10:22850540(-) A-I      intronic chr10:22837871(-) A-I      intronic chr10:22850661(-) A-I      intronic chr10:22891117(-) A-I      intronic chr10:22964517(-) A-I      intronic chr10:22883529(-) A-I      intronic chr10:22850718(-) A-I      intronic chr10:22998006(-) A-I      intronic chr10:22850767(-) A-I      intronic chr10:22835543(-) A-I      intronic chr10:22986619(-) A-I      intronic chr10:22995991(-) A-I      intronic chr10:22956997(-) A-I      intronic chr10:22883409(-) A-I      intronic chr10:22941184(-) A-I      intronic chr10:22850675(-) A-I      intronic chr10:22934240(-) A-I      intronic chr10:22949292(-) A-I      intronic chr10:22887107(-) A-I      intronic chr10:22850620(-) A-I      intronic chr10:22964367(-) A-I      intronic chr10:22997945(-) A-I      intronic chr10:22954404(-) A-I      intronic chr10:22949291(-) A-I      intronic chr10:22941971(-) A-I      intronic chr10:22949217(-) A-I      intronic chr10:22948655(-) A-I      intronic chr10:22942013(-) A-I      intronic chr10:22977590(-) A-I      intronic chr10:22883392(-) A-I      intronic chr10:22934399(-) A-I      intronic chr10:22835452(-) A-I      intronic chr10:22941143(-) A-I      intronic chr10:22950378(-) A-I      intronic chr10:22949288(-) A-I      intronic chr10:22976658(-) A-I      intronic chr10:22957080(-) A-I      intronic chr10:22975633(-) A-I      intronic chr10:22835714(-) A-I      intronic chr10:22843941(-) A-I      intronic chr10:22944981(-) A-I      intronic chr10:22842379(-) A-I      intronic chr10:22944971(-) A-I      intronic chr10:22825581(-) A-I      3'UTR chr10:22964415(-) A-I      intronic chr10:22865871(-) A-I      intronic chr10:22997939(-) A-I      intronic chr10:22948478(-) A-I      intronic chr10:22859884(-) A-I      intronic chr10:22978552(-) A-I      intronic chr10:22975545(-) A-I      intronic chr10:22899264(-) A-I      intronic chr10:22853666(-) A-I      intronic chr10:22976623(-) A-I      intronic chr10:22853751(-) A-I      intronic chr10:22859928(-) A-I      intronic chr10:22851985(-) A-I      intronic chr10:22978553(-) A-I      intronic chr10:22976622(-) A-I      intronic chr10:22883602(-) A-I      intronic chr10:22859258(-) A-I      intronic chr10:22851945(-) A-I      intronic chr10:22944943(-) A-I      intronic chr10:22948446(-) A-I      intronic chr10:22984595(-) A-I      intronic chr10:22944958(-) A-I      intronic chr10:22858989(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PIP4K2A	chr10:22859258(-) A-I intron -    22327324 chr10:22825581(-) A-I exon 3'UTR    21960545 chr10:22976622(-) A-G intron -    22484847 chr10:22976623(-) A-G intron -    22484847 chr10:22976658(-) A-G intron -    22484847 chr10:22978552(-) A-G intron -    22484847 chr10:22978553(-) A-G intron -    22484847 chr10:22984595(-) A-G intron -    22484847 chr10:22851288(-) A-G intron -    22484847 chr10:22950378(-) A-G intron -    22484847 chr10:22950410(-) A-G intron -    22484847 chr10:22950491(-) A-G intron -    22484847 chr10:22950492(-) A-G intron -    22484847 chr10:22950551(-) A-G intron -    22484847 chr10:22950564(-) A-G intron -    22484847 chr10:22950565(-) A-G intron -    22484847 chr10:22859258(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIP4K2A	chr10:22824145-22824146(-) m6A 3'UTR       - chr10:22824159-22824160(-) m6A 3'UTR       - chr10:22824444-22824445(-) m6A 3'UTR       27773535 chr10:22824513-22824514(-) m6A 3'UTR       27773535 chr10:22824521-22824522(-) m6A 3'UTR       27773535 chr10:22824559-22824560(-) m6A 3'UTR       27773535 chr10:22824573-22824574(-) m6A 3'UTR       27773535 chr10:22825416-22825417(-) m6A 3'UTR       24284625//27773535 chr10:22825519-22825520(-) m6A 3'UTR       24284625//24981863//26404942//27773535 chr10:22825556-22825557(-) m6A 3'UTR       24981863//26404942//27773535 chr10:22825624-22825625(-) m6A 3'UTR       24981863//26404942//27773535 chr10:22825678-22825679(-) m6A 3'UTR       24981863//26404942//27773535 chr10:22825745-22825746(-) m6A 3'UTR       24981863//27773535 chr10:22825802-22825803(-) m6A 3'UTR       24981863//27773535 chr10:22825838-22825839(-) m6A 3'UTR//exon       27773535 chr10:22826020-22826021(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr10:22826052-22826053(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr10:22826057-22826058(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr10:22826089-22826090(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr10:22826100-22826101(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr10:22826106-22826107(-) m6A 3'UTR//exon       25456834 chr10:22826110-22826111(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr10:22826154-22826155(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr10:22826177-22826178(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr10:22826184-22826185(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr10:22828434-22828435(-) m6A exon//intron       24284625//24209618//24981863//28052920//27773535//27371828//22608085 chr10:22828459-22828460(-) m6A exon//intron       24284625//24981863//28052920//27773535//27371828//22608085 chr10:22828905-22828906(-) m6A CDS       24284625//24209618//27773535 chr10:22828913-22828914(-) m6A CDS       24284625//24209618//27773535 chr10:22830764-22830765(-) m6A CDS       24284625//24209618//27773535//27371828 chr10:22830803-22830804(-) m6A CDS       24209618//27773535//27371828 chr10:22830834-22830835(-) m6A CDS       24209618//24981863//27773535//27371828 chr10:22830907-22830908(-) m6A CDS       24981863//27773535//27371828 chr10:22830950-22830951(-) m6A CDS       24981863//27773535//27371828 chr10:22839605-22839606(-) m6A CDS       24981863//27773535 chr10:22839692-22839693(-) m6A CDS       27773535 chr10:22856494-22856495(-) m6A exon//intron       27773535 chr10:22856515-22856516(-) m6A exon//intron       27773535 chr10:22856544-22856545(-) m6A exon//intron       27773535 chr10:22856576-22856577(-) m6A exon//intron       27773535 chr10:22896946-22896947(-) m6A CDS//exon       27773535 chr10:22898566-22898567(-) m6A CDS//exon       27773535 chr10:22898637-22898638(-) m6A 5'UTR//CDS//exon       27773535 chr10:22930975-22930976(-) m6A exon//intron       27773535 chr10:22935188-22935189(-) m6A exon//intron       27773535 chr10:23003194-23003195(-) m1A CDS       26863196//26863410 chr10:23003203-23003204(-) m6A CDS       24209618//27371828 chr10:23003209-23003210(-) m6A CDS       24209618//27371828 chr10:23003269-23003270(-) m6A 5'UTR       24209618//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-3p	Exosome K562 cells     24460325
	PIP4K2A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-3p
Interactor2: PIP4K2A

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	CDS
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).