Detail Information

Basic Information:


  VIRBase ID:  

VHID00283181

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8925

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-3p:           BACH1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-2-3p BACH1
miRBase
Accession/Entrez ID		 MIMAT0000997 571
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - BACH-1//BTBD24

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BACH1
chr21:30724971(+) A-I      ncRNA
chr21:30730859(+) A-I      intronic
chr21:30730865(+) A-I      intronic
chr21:30730874(+) A-I      intronic
chr21:30730900(+) A-I      intronic
chr21:30731002(+) A-I      intronic
chr21:30731011(+) A-I      intronic
chr21:30710135(+) A-I      intronic
chr21:30724515(+) A-I      intronic
chr21:30731043(+) A-I      intronic
chr21:30724443(+) A-I      intronic
chr21:30730909(+) A-I      intronic
chr21:30730903(+) A-I      intronic
chr21:30724637(+) A-I      intronic
chr21:30730901(+) A-I      intronic
chr21:30730910(+) A-I      intronic
chr21:30731074(+) A-I      intronic
chr21:30731018(+) A-I      intronic
chr21:30731016(+) A-I      intronic
chr21:30730967(+) A-I      intronic
chr21:30730875(+) A-I      intronic
chr21:30712017(+) A-I      intronic
chr21:30712018(+) A-I      intronic
chr21:30712167(+) A-I      intronic
chr21:30725126(+) A-I      intronic
chr21:30724395(+) A-I      intronic
chr21:30725286(+) A-I      intronic
chr21:30725133(+) A-I      intronic
chr21:30724493(+) A-I      intronic
chr21:30724550(+) A-I      intronic
chr21:30730899(+) A-I      intronic
chr21:30730884(+) A-I      intronic
chr21:30730835(+) A-I      intronic
chr21:30724972(+) A-I      ncRNA
chr21:30710129(+) A-I      intronic
chr21:30731006(+) A-I      intronic
chr21:30730946(+) A-I      intronic
chr21:30725217(+) A-I      intronic
chr21:30710829(+) A-I      intronic
chr21:30725353(+) A-I      intronic
chr21:30730941(+) A-I      intronic
chr21:30724450(+) A-I      intronic
chr21:30724559(+) A-I      intronic
chr21:30710758(+) A-I      intronic
chr21:30724476(+) A-I      intronic
chr21:30724509(+) A-I      intronic
chr21:30725088(+) A-I      intronic
chr21:30730950(+) A-I      intronic
chr21:30724475(+) A-I      intronic
chr21:30725442(+) A-I      intronic
chr21:30710835(+) A-I      intronic
chr21:30730808(+) A-I      intronic
chr21:30725084(+) A-I      intronic
chr21:30725308(+) A-I      intronic
chr21:30730896(+) A-I      intronic
chr21:30710718(+) A-I      intronic
chr21:30730940(+) A-I      intronic
chr21:30725296(+) A-I      intronic
chr21:30730914(+) A-I      intronic
chr21:30725172(+) A-I      intronic
chr21:30710205(+) A-I      intronic
chr21:30724942(+) A-I      ncRNA
chr21:30724981(+) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BACH1
chr21:30710726(+) A-I intron -    22327324
chr21:30710726(+) A-G intron -    22484847
chr21:30725281(+) A-G intron -    22484847
chr21:30725296(+) A-G intron -    22484847
chr21:30725308(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BACH1
chr21:30660396-30660397(+) m6A 5'UTR//intron       24981863
chr21:30693726-30693727(+) m6A CDS       24284625
chr21:30698539-30698540(+) m6A CDS       24209618//24981863//26404942//22575960//22608085
chr21:30698551-30698552(+) m6A CDS       24209618//24981863//26404942//22575960//22608085
chr21:30698601-30698602(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698612-30698613(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698626-30698627(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698643-30698644(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698685-30698686(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698699-30698700(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698746-30698747(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698760-30698761(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30698850-30698851(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30698887-30698888(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699005-30699006(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699091-30699092(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699101-30699102(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699169-30699170(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699222-30699223(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30699329-30699330(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30699370-30699371(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr21:30699422-30699423(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699485-30699486(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr21:30699498-30699499(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr21:30701937-30701938(+) m6A CDS       24209618//22608085
chr21:30701971-30701972(+) m6A CDS       24284625//24209618//22608085
chr21:30714779-30714780(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714789-30714790(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714799-30714800(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714841-30714842(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30714931-30714932(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr21:30715002-30715003(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085
chr21:30715081-30715082(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr21:30715154-30715155(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr21:30715175-30715176(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr21:30715326-30715327(+) m6A 3'UTR//intron       24209618//24981863//22608085
chr21:30715383-30715384(+) m6A 3'UTR//intron       24209618//24981863//26404942//22608085
chr21:30715392-30715393(+) m6A 3'UTR//intron       24209618//24981863//26404942//22608085
chr21:30715463-30715464(+) m6A 3'UTR//intron       24284625//24981863//26404942//22608085
chr21:30715478-30715479(+) m6A 3'UTR//intron       24284625//24981863//26404942//22608085
chr21:30715499-30715500(+) m6A 3'UTR//intron       24284625//24981863//26404942//22608085
chr21:30715809-30715810(+) m6A 3'UTR//intron       24209618//24981863
chr21:30715902-30715903(+) m6A 3'UTR//intron       24209618//24981863
chr21:30715948-30715949(+) m6A 3'UTR//intron       24981863
chr21:30718077-30718078(+) m6A 3'UTR//intron       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-2-3p
Exosome K562 cells     24460325
BACH1
Chromatin K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-2-3p
Interactor2: BACH1

Evidence Support:


Strong-Evidence Dual luciferase reporter assay
Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VmiReg

References:


[1]PMID 23170179 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description Each method has inherent advantages and limitations, but the combination of these approaches have been successful in identifying many miRNA targets (Table 1). Table 1 List of experimentally validated cellular targets of KSHV- and EBV- encoded miRNAs. The normal cellular functions of these proteins and the effect of their knockdown during viral infection are also listed. The targets that are underlined are repressed by both KSHV- and EBV-encoded miRNAs.
[2]PMID 22291592 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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