Basic Information:

  VIRBase ID:  

VHID00283000

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          PCNX3:  NM_032223     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	PCNX3
miRBase Accession/Entrez ID	MIMAT0000996	399909
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PCNXL3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PCNX3	chr11:65388971(+) A-I      intronic chr11:65399051(+) A-I      intronic chr11:65399034(+) A-I      intronic chr11:65398963(+) A-I      intronic chr11:65398899(+) A-I      intronic chr11:65398894(+) A-I      intronic chr11:65398952(+) A-I      intronic chr11:65398983(+) A-I      intronic chr11:65400390(+) A-I      intronic chr11:65400240(+) A-I      intronic chr11:65400295(+) A-I      intronic chr11:65400319(+) A-I      intronic chr11:65398919(+) A-I      intronic chr11:65400381(+) A-I      intronic chr11:65400355(+) A-I      intronic chr11:65400333(+) A-I      intronic chr11:65400309(+) A-I      intronic chr11:65400255(+) A-I      intronic chr11:65399062(+) A-I      intronic chr11:65400236(+) A-I      intronic chr11:65400490(+) A-I      intronic chr11:65388753(+) A-I      intronic chr11:65399036(+) A-I      intronic chr11:65400399(+) A-I      intronic chr11:65400463(+) A-I      intronic chr11:65399300(+) A-I      intronic chr11:65398972(+) A-I      intronic chr11:65400302(+) A-I      intronic chr11:65399032(+) A-I      intronic chr11:65398851(+) A-I      intronic chr11:65398966(+) A-I      intronic chr11:65400328(+) A-I      intronic chr11:65399045(+) A-I      intronic chr11:65399009(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	PCNX3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: PCNX3

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).