Basic Information:

  VIRBase ID:  

VHID00282163

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          PDCD1LG2:  NM_025239     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	PDCD1LG2
miRBase Accession/Entrez ID	MIMAT0000996	80380
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	B7DC//bA574F11.2//Btdc//CD273//PD-L2//PDCD1L2//PDL2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PDCD1LG2	chr9:5526621(+) A-I      intronic chr9:5526461(+) A-I      intronic chr9:5525270(+) A-I      intronic chr9:5515736(+) A-I      intronic chr9:5528519(+) A-I      intronic chr9:5515751(+) A-I      intronic chr9:5515771(+) A-I      intronic chr9:5515776(+) A-I      intronic chr9:5515838(+) A-I      intronic chr9:5515843(+) A-I      intronic chr9:5515918(+) A-I      intronic chr9:5526538(+) A-I      intronic chr9:5516152(+) A-I      intronic chr9:5515816(+) A-I      intronic chr9:5526658(+) A-I      intronic chr9:5526571(+) A-I      intronic chr9:5525265(+) A-I      intronic chr9:5526567(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PDCD1LG2	chr9:5525265(+) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PDCD1LG2	chr9:5534982-5534983(+) m6A CDS       24981863 chr9:5535020-5535021(+) m6A CDS       24981863 chr9:5549352-5549353(+) m6A CDS       24981863 chr9:5549378-5549379(+) m6A CDS       24981863 chr9:5563174-5563175(+) m6A CDS       24981863 chr9:5563203-5563204(+) m6A CDS       24981863 chr9:5569959-5569960(+) m6A 3'UTR       24981863 chr9:5570014-5570015(+) m6A 3'UTR       24981863 chr9:5570021-5570022(+) m6A 3'UTR       24981863 chr9:5570099-5570100(+) m6A 3'UTR       24209618//24981863 chr9:5570111-5570112(+) m6A 3'UTR       24209618//24981863 chr9:5570134-5570135(+) m6A 3'UTR       24209618//24981863 chr9:5570156-5570157(+) m6A 3'UTR       24209618//24981863 chr9:5570227-5570228(+) m6A 3'UTR       24209618//24981863 chr9:5570264-5570265(+) m6A 3'UTR       24209618//24981863 chr9:5570349-5570350(+) m6A 3'UTR       24981863 chr9:5570418-5570419(+) m6A 3'UTR       24981863 chr9:5570433-5570434(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	PDCD1LG2	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: PDCD1LG2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

[1]PMID	31856276	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	B cells	Interactor2 expression	None
Description	The 3'UTR sequences of the PD-L1 and PD-L2 genes were scanned for potential binding sites to EBV miRs using the miRanda program. Only 13 EBV miRs were found to have putative binding sites located on PD-L1 and/or PD-L2 (supplemental Table 2).

[2]PMID	22291592	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).