Basic Information:

  VIRBase ID:  

VHID00281991

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          YTHDC2:  NM_022828     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	YTHDC2
miRBase Accession/Entrez ID	MIMAT0000996	64848
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CAHL//hYTHDC2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	YTHDC2	chr5:112853806(+) A-I      intronic chr5:112853719(+) A-I      intronic chr5:112853715(+) A-I      intronic chr5:112857241(+) A-I      intronic chr5:112857285(+) A-I      intronic chr5:112857353(+) A-I      intronic chr5:112925335(+) A-I      intronic chr5:112925399(+) A-I      intronic chr5:112925374(+) A-I      intronic chr5:112925370(+) A-I      intronic chr5:112925203(+) A-I      intronic chr5:112894540(+) A-I      intronic chr5:112864489(+) A-I      intronic chr5:112854002(+) A-I      intronic chr5:112857317(+) A-I      intronic chr5:112924459(+) A-I      intronic chr5:112854137(+) A-I      intronic chr5:112925381(+) A-I      intronic chr5:112894539(+) A-I      intronic chr5:112857266(+) A-I      intronic chr5:112854164(+) A-I      intronic chr5:112854138(+) A-I      intronic chr5:112854133(+) A-I      intronic chr5:112925262(+) A-I      intronic chr5:112925368(+) A-I      intronic chr5:112925267(+) A-I      intronic chr5:112857173(+) A-I      intronic chr5:112893282(+) A-I      intronic chr5:112924561(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	YTHDC2	chr5:112853991(+) A-G intron -    22484847 chr5:112854133(+) A-G intron -    22484847 chr5:112854134(+) A-G intron -    22484847 chr5:112854137(+) A-G intron -    22484847 chr5:112854138(+) A-G intron -    22484847 chr5:112857251(+) A-G intron -    22484847 chr5:112906050(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	YTHDC2	chr5:112860827-112860828(+) m6A CDS//intron       24981863 chr5:112927754-112927755(+) m6A CDS//exon       24981863 chr5:112929007-112929008(+) m6A CDS//exon       22608085 chr5:112929022-112929023(+) m6A CDS//exon       22608085 chr5:112929066-112929067(+) m6A CDS//exon       24284625//24981863//22608085 chr5:112929136-112929137(+) m6A exon//intron       24284625//24981863//22608085 chr5:112929179-112929180(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929197-112929198(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929241-112929242(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929301-112929302(+) m6A 3'UTR//exon       24284625//24981863//22608085 chr5:112929542-112929543(+) m6A 3'UTR//exon       24981863//22608085 chr5:112929593-112929594(+) m6A 3'UTR//exon       24981863//22608085 chr5:112929630-112929631(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929642-112929643(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929655-112929656(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr5:112929737-112929738(+) m6A 3'UTR//exon       27773535 chr5:112930025-112930026(+) m6A 3'UTR//exon       24981863 chr5:112930042-112930043(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	YTHDC2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: YTHDC2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).