Detail Information

Basic Information:


  VIRBase ID:  

VHID00281446

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:           MEX3C:      

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Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-2-5p MEX3C
miRBase
Accession/Entrez ID		 MIMAT0000996 51320
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - BM-013//MEX-3C//RKHD2//RNF194

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MEX3C
chr18:48707141(-) A-I      intronic
chr18:48706959(-) A-I      intronic
chr18:48706874(-) A-I      intronic
chr18:48705645(-) A-I      intronic
chr18:48705534(-) A-I      intronic
chr18:48705143(-) A-I      intronic
chr18:48705122(-) A-I      intronic
chr18:48711072(-) A-I      intronic
chr18:48705086(-) A-I      intronic
chr18:48705082(-) A-I      intronic
chr18:48705081(-) A-I      intronic
chr18:48706940(-) A-I      intronic
chr18:48711024(-) A-I      intronic
chr18:48705644(-) A-I      intronic
chr18:48705121(-) A-I      intronic
chr18:48707035(-) A-I      intronic
chr18:48705033(-) A-I      intronic
chr18:48705062(-) A-I      intronic
chr18:48705615(-) A-I      intronic
chr18:48705108(-) A-I      intronic
chr18:48705167(-) A-I      intronic
chr18:48704995(-) A-I      intronic
chr18:48705063(-) A-I      intronic
chr18:48705512(-) A-I      intronic
chr18:48705470(-) A-I      intronic
chr18:48705217(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MEX3C
chr18:48702125-48702126(-) m6A 3'UTR       26404942
chr18:48702131-48702132(-) m6A 3'UTR       26404942
chr18:48702485-48702486(-) m6A 3'UTR       26404942
chr18:48702493-48702494(-) m6A 3'UTR       26404942
chr18:48702549-48702550(-) m6A 3'UTR       24981863//26404942//22608085
chr18:48702579-48702580(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr18:48702644-48702645(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr18:48702682-48702683(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr18:48702755-48702756(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr18:48703041-48703042(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr18:48703106-48703107(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:48703158-48703159(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:48703169-48703170(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:48703178-48703179(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:48703228-48703229(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:48703270-48703271(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr18:48703510-48703511(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr18:48703596-48703597(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr18:48703634-48703635(-) m6A CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr18:48703671-48703672(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr18:48703721-48703722(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr18:48703777-48703778(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr18:48703792-48703793(-) Y CDS//exon       26075521
chr18:48703898-48703899(-) m6A CDS//exon       24284625//24209618//24981863
chr18:48703916-48703917(-) m6A CDS//exon       24981863
chr18:48723230-48723231(-) m6A CDS//intron       24209618//25456834//24981863//27371828//27773536
chr18:48723280-48723281(-) m6A CDS//intron       24209618//25456834//24981863//27371828//27773536
chr18:48723322-48723323(-) m6A CDS//intron       24209618//25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-2-5p
Exosome B cell line (Raji)     21505438
MEX3C
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: MEX3C

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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