Detail Information

Basic Information:


  VIRBase ID:  

VHID00281325

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:           SERP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-2-5p SERP1
miRBase
Accession/Entrez ID		 MIMAT0000996 27230
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - RAMP4

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SERP1
chr3:150300382(-) A-I      intronic
chr3:150291875(-) A-I      intronic
chr3:150289278(-) A-I      intronic
chr3:150295435(-) A-I      intronic
chr3:150287490(-) A-I      intronic
chr3:150291900(-) A-I      intronic
chr3:150295300(-) A-I      intronic
chr3:150295194(-) A-I      intronic
chr3:150291794(-) A-I      intronic
chr3:150291780(-) A-I      intronic
chr3:150290521(-) A-I      intronic
chr3:150290454(-) A-I      intronic
chr3:150289284(-) A-I      intronic
chr3:150290424(-) A-I      intronic
chr3:150289285(-) A-I      intronic
chr3:150303222(-) A-I      intronic
chr3:150295303(-) A-I      intronic
chr3:150303267(-) A-I      intronic
chr3:150297420(-) A-I      intronic
chr3:150271356(-) A-I      intronic
chr3:150303194(-) A-I      intronic
chr3:150289194(-) A-I      intronic
chr3:150300306(-) A-I      intronic
chr3:150295306(-) A-I      intronic
chr3:150286523(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SERP1
chr3:150261666(-) A-I exon 3'UTR    19478186
chr3:150260337(-) A-I exon 3'UTR    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SERP1
chr3:150260774-150260775(-) m6A 3'UTR       26404942
chr3:150260784-150260785(-) m6A 3'UTR       26404942
chr3:150260810-150260811(-) m6A 3'UTR       26404942
chr3:150260819-150260820(-) m6A 3'UTR       26404942
chr3:150260848-150260849(-) m6A 3'UTR       26404942
chr3:150261412-150261413(-) m6A 3'UTR       26404942
chr3:150261992-150261993(-) m6A 3'UTR       -
chr3:150262042-150262043(-) m6A 3'UTR       24284625
chr3:150262162-150262163(-) m6A 3'UTR       24284625//24981863//22575960//22608085
chr3:150262195-150262196(-) m6A 3'UTR       24284625//24981863//22575960//22608085
chr3:150263206-150263207(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr3:150263211-150263212(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr3:150263216-150263217(-) m6A 3'UTR//intron       24284625//24981863//22608085
chr3:150263532-150263533(-) m6A CDS//intron       27773535//27371828//27773536
chr3:150263843-150263844(-) m6A CDS       27773535//27371828//27773536
chr3:150263872-150263873(-) m6A CDS       24284625//27773535//27371828//27773536//22575960
chr3:150264036-150264037(-) m6A 5'UTR       24284625//27371828//27773536//22575960
chr3:150264091-150264092(-) m6A 5'UTR       24284625//27371828//27773536//22575960
chr3:150264291-150264292(-) m6A 5'UTR       24981863//27371828//27773536
chr3:150264540-150264541(-) m6A 5'UTR       24981863
chr3:150264570-150264571(-) m6A 5'UTR       24981863
chr3:150264622-150264623(-) m6A 5'UTR//exon       24981863//27773535
chr3:150264659-150264660(-) m6A 5'UTR//exon       24981863//27773535
chr3:150264672-150264673(-) m6A 5'UTR//exon       24981863//27773535
chr3:150264708-150264709(-) m6A 5'UTR//exon       27773535
chr3:150264788-150264789(-) m6A 5'UTR//exon       27773535
chr3:150283888-150283889(-) m6A exon//intron       27773535
chr3:150283926-150283927(-) m6A exon//intron       27773535
chr3:150283932-150283933(-) m6A exon//intron       27773535
chr3:150283969-150283970(-) m6A exon//intron       24981863//27773535
chr3:150284360-150284361(-) m6A exon//intron       27773535
chr3:150284386-150284387(-) m6A exon//intron       27773535
chr3:150284504-150284505(-) m6A exon//intron       27773535
chr3:150284508-150284509(-) m6A exon//intron       27773535//22608085
chr3:150284589-150284590(-) m6A exon//intron       24981863//27773535//22608085
chr3:150284596-150284597(-) m6A exon//intron       24981863//27773535//22608085
chr3:150284604-150284605(-) m6A exon//intron       24209618//24981863//27773535//22608085
chr3:150284635-150284636(-) m6A exon//intron       24209618//24981863//27773535//22608085
chr3:150284676-150284677(-) m6A exon//intron       24284625//24981863//27773535//22608085
chr3:150284756-150284757(-) m6A exon//intron       24284625//27773535//22608085
chr3:150284781-150284782(-) m6A exon//intron       24284625//27773535//22608085
chr3:150284805-150284806(-) m6A exon//intron       24284625//27773535//22608085
chr3:150284860-150284861(-) m6A exon//intron       24284625//27773535//22608085
chr3:150300908-150300909(-) m6A exon//intron       24284625//27773535
chr3:150320798-150320799(-) m6A 5'UTR//exon       27773535
chr3:150320806-150320807(-) m6A 5'UTR//exon       27773535
chr3:150320932-150320933(-) m6A 5'UTR//exon       25456834//24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-2-5p
Exosome B cell line (Raji)     21505438
SERP1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: SERP1

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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