Detail Information

Basic Information:


  VIRBase ID:  

VHID00281212

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8935

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:           RAB3GAP2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-2-5p RAB3GAP2
miRBase
Accession/Entrez ID		 MIMAT0000996 25782
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - p150//RAB3-GAP150//RAB3GAP150//SPG69//WARBM2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RAB3GAP2
chr1:220377819(-) A-I      intronic
chr1:220376233(-) A-I      intronic
chr1:220331907(-) A-I      intronic
chr1:220331911(-) A-I      intronic
chr1:220331915(-) A-I      intronic
chr1:220331920(-) A-I      intronic
chr1:220331921(-) A-I      intronic
chr1:220331939(-) A-I      intronic
chr1:220331943(-) A-I      intronic
chr1:220331947(-) A-I      intronic
chr1:220331956(-) A-I      intronic
chr1:220331958(-) A-I      intronic
chr1:220347173(-) A-I      intronic
chr1:220347178(-) A-I      intronic
chr1:220347195(-) A-I      intronic
chr1:220347218(-) A-I      intronic
chr1:220347234(-) A-I      intronic
chr1:220347240(-) A-I      intronic
chr1:220443553(-) A-I      intronic
chr1:220347198(-) A-I      intronic
chr1:220331959(-) A-I      intronic
chr1:220377752(-) A-I      intronic
chr1:220377763(-) A-I      intronic
chr1:220377806(-) A-I      intronic
chr1:220336810(-) A-I      intronic
chr1:220354602(-) A-I      intronic
chr1:220375281(-) A-I      intronic
chr1:220370090(-) A-I      intronic
chr1:220374683(-) A-I      intronic
chr1:220375350(-) A-I      intronic
chr1:220375425(-) A-I      intronic
chr1:220374634(-) A-I      intronic
chr1:220370116(-) A-I      intronic
chr1:220370110(-) A-I      intronic
chr1:220370394(-) A-I      intronic
chr1:220374974(-) A-I      intronic
chr1:220374953(-) A-I      intronic
chr1:220374647(-) A-I      intronic
chr1:220374910(-) A-I      intronic
chr1:220336820(-) A-I      intronic
chr1:220370500(-) A-I      intronic
chr1:220411475(-) A-I      intronic
chr1:220370414(-) A-I      intronic
chr1:220370526(-) A-I      intronic
chr1:220374858(-) A-I      intronic
chr1:220370087(-) A-I      intronic
chr1:220364908(-) A-I      intronic
chr1:220354628(-) A-I      intronic
chr1:220332055(-) A-I      intronic
chr1:220354587(-) A-I      intronic
chr1:220375412(-) A-I      intronic
chr1:220348636(-) A-I      intronic
chr1:220375024(-) A-I      intronic
chr1:220375020(-) A-I      intronic
chr1:220370172(-) A-I      intronic
chr1:220370104(-) A-I      intronic
chr1:220374938(-) A-I      intronic
chr1:220374587(-) A-I      intronic
chr1:220375060(-) A-I      intronic
chr1:220369955(-) A-I      intronic
chr1:220370439(-) A-I      intronic
chr1:220328191(-) A-I      intronic
chr1:220333109(-) A-I      intronic
chr1:220375021(-) A-I      intronic
chr1:220375431(-) A-I      intronic
chr1:220374986(-) A-I      intronic
chr1:220374939(-) A-I      intronic
chr1:220370057(-) A-I      intronic
chr1:220375115(-) A-I      intronic
chr1:220370498(-) A-I      intronic
chr1:220375506(-) A-I      intronic
chr1:220376022(-) A-I      intronic
chr1:220377907(-) A-I      intronic
chr1:220370494(-) A-I      intronic
chr1:220348637(-) A-I      intronic
chr1:220336424(-) A-I      intronic
chr1:220369969(-) A-I      intronic
chr1:220336381(-) A-I      intronic
chr1:220375455(-) A-I      intronic
chr1:220375041(-) A-I      intronic
chr1:220355293(-) A-I      intronic
chr1:220370097(-) A-I      intronic
chr1:220375385(-) A-I      intronic
chr1:220336473(-) A-I      intronic
chr1:220374980(-) A-I      intronic
chr1:220375341(-) A-I      intronic
chr1:220437025(-) A-I      intronic
chr1:220409723(-) A-I      intronic
chr1:220436831(-) A-I      intronic
chr1:220355350(-) A-I      intronic
chr1:220375382(-) A-I      intronic
chr1:220375398(-) A-I      intronic
chr1:220331983(-) A-I      intronic
chr1:220409714(-) A-I      intronic
chr1:220375505(-) A-I      intronic
chr1:220409747(-) A-I      intronic
chr1:220397272(-) A-I      intronic
chr1:220370525(-) A-I      intronic
chr1:220370025(-) A-I      intronic
chr1:220375343(-) A-I      intronic
chr1:220387634(-) A-I      intronic
chr1:220336404(-) A-I      intronic
chr1:220377360(-) A-I      intronic
chr1:220375379(-) A-I      intronic
chr1:220375121(-) A-I      intronic
chr1:220332001(-) A-I      intronic
chr1:220370425(-) A-I      intronic
chr1:220377913(-) A-I      intronic
chr1:220336398(-) A-I      intronic
chr1:220375324(-) A-I      intronic
chr1:220375424(-) A-I      intronic
chr1:220376082(-) A-I      intronic
chr1:220375463(-) A-I      intronic
chr1:220374966(-) A-I      intronic
chr1:220370170(-) A-I      intronic
chr1:220332050(-) A-I      intronic
chr1:220375390(-) A-I      intronic
chr1:220370007(-) A-I      intronic
chr1:220377386(-) A-I      intronic
chr1:220370014(-) A-I      intronic
chr1:220354513(-) A-I      intronic
chr1:220378407(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RAB3GAP2
chr1:220331961(-) A-I intron -    15258596
chr1:220331983(-) A-I intron -    15258596
chr1:220332001(-) A-I intron -    15258596
chr1:220336364(-) A-I intron -    21960545
chr1:220336398(-) A-I intron -    21960545
chr1:220336404(-) A-I intron -    21960545
chr1:220336424(-) A-I intron -    21960545
chr1:220336473(-) A-I intron -    21960545
chr1:220436086(-) A-I intron -    21960545
chr1:220436087(-) A-I intron -    21960545
chr1:220333109(-) A-G intron -    22484847
chr1:220336398(-) A-G intron -    22484847
chr1:220336404(-) A-G intron -    22484847
chr1:220336424(-) A-G intron -    22484847
chr1:220336473(-) A-G intron -    22484847
chr1:220354587(-) A-G intron -    22484847
chr1:220355293(-) A-G intron -    22484847
chr1:220355350(-) A-G intron -    22484847
chr1:220369955(-) A-G intron -    22484847
chr1:220369969(-) A-G intron -    22484847
chr1:220370007(-) A-G intron -    22484847
chr1:220370014(-) A-G intron -    22484847
chr1:220370025(-) A-G intron -    22484847
chr1:220370057(-) A-G intron -    22484847
chr1:220370097(-) A-G intron -    22484847
chr1:220370104(-) A-G intron -    22484847
chr1:220370494(-) A-G intron -    22484847
chr1:220370525(-) A-G intron -    22484847
chr1:220374938(-) A-G intron -    22484847
chr1:220374939(-) A-G intron -    22484847
chr1:220374966(-) A-G intron -    22484847
chr1:220374980(-) A-G intron -    22484847
chr1:220374986(-) A-G intron -    22484847
chr1:220375020(-) A-G intron -    22484847
chr1:220375021(-) A-G intron -    22484847
chr1:220375024(-) A-G intron -    22484847
chr1:220375041(-) A-G intron -    22484847
chr1:220375115(-) A-G intron -    22484847
chr1:220375121(-) A-G intron -    22484847
chr1:220375324(-) A-G intron -    22484847
chr1:220375341(-) A-G intron -    22484847
chr1:220375343(-) A-G intron -    22484847
chr1:220375379(-) A-G intron -    22484847
chr1:220375382(-) A-G intron -    22484847
chr1:220375385(-) A-G intron -    22484847
chr1:220375390(-) A-G intron -    22484847
chr1:220375398(-) A-G intron -    22484847
chr1:220375412(-) A-G intron -    22484847
chr1:220375424(-) A-G intron -    22484847
chr1:220375431(-) A-G intron -    22484847
chr1:220375455(-) A-G intron -    22484847
chr1:220375463(-) A-G intron -    22484847
chr1:220375506(-) A-G intron -    22484847
chr1:220397272(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RAB3GAP2
chr1:220323969-220323970(-) m6A 3'UTR       24981863
chr1:220323981-220323982(-) m6A 3'UTR       24981863
chr1:220324697-220324698(-) m6A CDS//exon       27371828
chr1:220324728-220324729(-) m6A CDS//exon       27371828
chr1:220324737-220324738(-) m6A CDS//exon       27371828
chr1:220324746-220324747(-) m6A CDS//exon       27371828
chr1:220326562-220326563(-) m6A CDS//exon       -
chr1:220326647-220326648(-) m6A CDS//exon       -
chr1:220326789-220326790(-) m6A exon//intron       -
chr1:220340913-220340914(-) m6A CDS       24981863
chr1:220340923-220340924(-) m6A CDS       24981863
chr1:220340952-220340953(-) m6A CDS       24981863
chr1:220340974-220340975(-) m6A CDS       24981863
chr1:220340979-220340980(-) m6A CDS       24981863
chr1:220363749-220363750(-) m6A CDS//exon       24981863
chr1:220406192-220406193(-) m6A CDS//exon//intron       27773535
chr1:220439402-220439403(-) m6A exon//intron       27773535
chr1:220439432-220439433(-) m6A exon//intron       27773535
chr1:220439527-220439528(-) m6A exon//intron       27773535
chr1:220439604-220439605(-) m6A exon//intron       27773535
chr1:220439866-220439867(-) m6A exon//intron       24284625//27773535//22608085
chr1:220439940-220439941(-) m6A exon//intron       24284625//24981863//27773535//22608085
chr1:220439989-220439990(-) m6A exon//intron       24284625//24981863//27773535//22608085
chr1:220440073-220440074(-) m6A exon//intron       27773535//22608085
chr1:220440090-220440091(-) m6A exon//intron       27773535//22608085
chr1:220440171-220440172(-) m6A exon//intron       27773535//22608085
chr1:220440184-220440185(-) m6A exon//intron       27773535//22608085
chr1:220440250-220440251(-) m6A exon//intron       24981863//27773535//22608085
chr1:220440378-220440379(-) m6A exon//intron       24981863//27773535//22608085
chr1:220440400-220440401(-) m6A exon//intron       24981863//27773535//22608085
chr1:220440422-220440423(-) m6A exon//intron       24981863//27773535//22608085
chr1:220440477-220440478(-) m6A exon//intron       24981863//27773535//22575960//22608085
chr1:220440492-220440493(-) m6A exon//intron       24981863//27773535//22575960//22608085
chr1:220440508-220440509(-) m6A exon//intron       24981863//27773535//22575960//22608085
chr1:220440562-220440563(-) m6A exon//intron       24981863//27773535//22575960//22608085
chr1:220440587-220440588(-) m6A exon//intron       24284625//24981863//27773535//22575960//22608085
chr1:220440596-220440597(-) m6A exon//intron       24284625//24981863//27773535//22575960//22608085
chr1:220440610-220440611(-) m6A exon//intron       24284625//24981863//27773535//22608085
chr1:220440674-220440675(-) m6A exon//intron       24981863//27773535//22608085
chr1:220440800-220440801(-) m6A exon//intron       27773535
chr1:220440864-220440865(-) m6A exon//intron       27773535
chr1:220440907-220440908(-) m6A exon//intron       27773535
chr1:220440919-220440920(-) m6A exon//intron       27773535
chr1:220440968-220440969(-) m6A exon//intron       27773535
chr1:220441189-220441190(-) m6A intron       -
chr1:220441209-220441210(-) m6A intron       -
chr1:220441238-220441239(-) m6A intron       -
chr1:220441253-220441254(-) m6A intron       -
chr1:220444507-220444508(-) m6A exon//intron       27773535
chr1:220445623-220445624(-) m6A CDS//exon       -
chr1:220445641-220445642(-) m6A CDS//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-2-5p
Exosome B cell line (Raji)     21505438
RAB3GAP2
Chromatin K562 cells     -
Cytosol HeLa-S3 cells|K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Plasma     23663360
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: RAB3GAP2

Evidence Support:


Strong-Evidence Luciferase reporter assay
Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

Starting a new search, please wait ...