Basic Information:

  VIRBase ID:  

VHID00281189

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          GTPBP4:  NM_012341     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	GTPBP4
miRBase Accession/Entrez ID	MIMAT0000996	23560
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CRFG//NGB//NOG1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GTPBP4	chr10:1047993(+) A-I      intronic chr10:1053406(+) A-I      intronic chr10:1045713(+) A-I      intronic chr10:1045794(+) A-I      intronic chr10:1059372(+) A-I      intronic chr10:1045128(+) A-I      intronic chr10:1045067(+) A-I      intronic chr10:1045071(+) A-I      intronic chr10:1045114(+) A-I      intronic chr10:1045158(+) A-I      intronic chr10:1045159(+) A-I      intronic chr10:1045241(+) A-I      intronic chr10:1036499(+) A-I      intronic chr10:1051104(+) A-I      intronic chr10:1045643(+) A-I      intronic chr10:1059185(+) A-I      intronic chr10:1040234(+) A-I      intronic chr10:1045188(+) A-I      intronic chr10:1045831(+) A-I      intronic chr10:1045840(+) A-I      intronic chr10:1045089(+) A-I      intronic chr10:1045869(+) A-I      intronic chr10:1035905(+) A-I      intronic chr10:1046242(+) A-I      intronic chr10:1036548(+) A-I      intronic chr10:1045191(+) A-I      intronic chr10:1052307(+) A-I      intronic chr10:1035945(+) A-I      intronic chr10:1059429(+) A-I      intronic chr10:1045244(+) A-I      intronic chr10:1038246(+) A-I      intronic chr10:1038229(+) A-I      intronic chr10:1045627(+) A-I      intronic chr10:1059053(+) A-I      intronic chr10:1045666(+) A-I      intronic chr10:1059400(+) A-I      intronic chr10:1045691(+) A-I      intronic chr10:1036496(+) A-I      intronic chr10:1036475(+) A-I      intronic chr10:1038219(+) A-I      intronic chr10:1045715(+) A-I      intronic chr10:1035816(+) A-I      intronic chr10:1045734(+) A-I      intronic chr10:1059460(+) A-I      intronic chr10:1059396(+) A-I      intronic chr10:1045737(+) A-I      intronic chr10:1051172(+) A-I      intronic chr10:1045746(+) A-I      intronic chr10:1059186(+) A-I      intronic chr10:1045749(+) A-I      intronic chr10:1051161(+) A-I      intronic chr10:1064520(+) A-I      3'UTR chr10:1064111(+) A-I      3'UTR chr10:1064627(+) A-I      3'UTR chr10:1064537(+) A-I      3'UTR chr10:1045248(+) A-I      intronic chr10:1035877(+) A-I      intronic chr10:1045348(+) A-I      intronic chr10:1045198(+) A-I      intronic chr10:1045152(+) A-I      intronic chr10:1059482(+) A-I      intronic chr10:1035329(+) A-I      intronic chr10:1045214(+) A-I      intronic chr10:1045109(+) A-I      intronic chr10:1059403(+) A-I      intronic chr10:1045644(+) A-I      intronic chr10:1036542(+) A-I      intronic chr10:1058980(+) A-I      intronic chr10:1037909(+) A-I      intronic chr10:1045788(+) A-I      intronic chr10:1054098(+) A-I      intronic chr10:1045650(+) A-I      intronic chr10:1045864(+) A-I      intronic chr10:1059278(+) A-I      intronic chr10:1045795(+) A-I      intronic chr10:1035756(+) A-I      intronic chr10:1035770(+) A-I      intronic chr10:1035265(+) A-I      intronic chr10:1054097(+) A-I      intronic chr10:1036408(+) A-I      intronic chr10:1045752(+) A-I      intronic chr10:1051292(+) A-I      intronic chr10:1035863(+) A-I      intronic chr10:1045689(+) A-I      intronic chr10:1036451(+) A-I      intronic chr10:1036516(+) A-I      intronic chr10:1035860(+) A-I      intronic chr10:1058998(+) A-I      intronic chr10:1059398(+) A-I      intronic chr10:1045200(+) A-I      intronic chr10:1045801(+) A-I      intronic chr10:1045649(+) A-I      intronic chr10:1055939(+) A-I      intronic chr10:1045329(+) A-I      intronic chr10:1045784(+) A-I      intronic chr10:1052458(+) A-I      intronic chr10:1046384(+) A-I      intronic chr10:1045670(+) A-I      intronic chr10:1039793(+) A-I      intronic chr10:1045258(+) A-I      intronic chr10:1046451(+) A-I      intronic chr10:1036593(+) A-I      intronic chr10:1052490(+) A-I      intronic chr10:1064274(+) A-I      3'UTR chr10:1064104(+) A-I      3'UTR chr10:1045698(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GTPBP4	chr10:1045643(+) A-I intron -    22327324 chr10:1036542(+) A-G intron -    22484847 chr10:1045152(+) A-G intron -    22484847 chr10:1045188(+) A-G intron -    22484847 chr10:1045198(+) A-G intron -    22484847 chr10:1045244(+) A-G intron -    22484847 chr10:1045643(+) A-G intron -    22484847 chr10:1045650(+) A-G intron -    22484847 chr10:1045752(+) A-G intron -    22484847 chr10:1045788(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GTPBP4	chr10:1034674-1034675(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr10:1034691-1034692(+) m6A 5'UTR//intron       24284625//24981863//22608085 chr10:1034709-1034710(+) m6A 5'UTR//intron       24284625//24981863 chr10:1038438-1038439(+) m6A 5'UTR//CDS//exon       24981863 chr10:1038455-1038456(+) m6A 5'UTR//CDS//exon       24981863//26404942 chr10:1038467-1038468(+) m6A 5'UTR//CDS//exon       24981863//26404942 chr10:1038487-1038488(+) m6A 5'UTR//CDS//exon       24981863//26404942 chr10:1038511-1038512(+) m6A 5'UTR//CDS//exon       24981863//26404942 chr10:1038562-1038563(+) m6A CDS//exon       26404942 chr10:1046623-1046624(+) m6A CDS//exon       22575960 chr10:1046641-1046642(+) m6A CDS//exon       22575960 chr10:1046662-1046663(+) m6A CDS//exon       22575960 chr10:1051802-1051803(+) m6A CDS//exon       27773535 chr10:1051841-1051842(+) m6A CDS//exon       27773535 chr10:1052990-1052991(+) m6A CDS//exon       24981863//27773535 chr10:1053031-1053032(+) m6A CDS//exon       24981863//27773535 chr10:1053085-1053086(+) m6A exon//intron       24981863//27773535//22575960 chr10:1054951-1054952(+) m6A CDS//exon       25456834//24981863//27773535//22575960 chr10:1056390-1056391(+) m6A CDS//exon       24981863//27773535 chr10:1058440-1058441(+) m6A CDS//exon       24981863//26404942//27773535 chr10:1058574-1058575(+) m6A CDS//exon       24209618//24981863//26404942//27773535 chr10:1058590-1058591(+) m6A CDS//exon       24209618//24981863//26404942//27773535 chr10:1060195-1060196(+) m6A CDS//exon       24209618//24981863//26404942//27773535 chr10:1061753-1061754(+) m6A CDS//exon       24981863//27773535//22575960 chr10:1061800-1061801(+) m6A CDS//exon       24981863//27773535//22575960 chr10:1063032-1063033(+) m6A CDS//exon       24981863//27773535//22575960 chr10:1063094-1063095(+) m6A CDS//exon       25456834//24981863//27773535//22575960//22608085 chr10:1063156-1063157(+) m6A CDS       24284625//25456834//24981863//26404942//27773535//22608085 chr10:1063259-1063260(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr10:1063269-1063270(+) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr10:1063304-1063305(+) m6A 3'UTR       24981863//26404942//27773535//22608085 chr10:1063373-1063374(+) m6A 3'UTR       24981863//27773535 chr10:1063421-1063422(+) m6A 3'UTR       27773535 chr10:1063468-1063469(+) m6A 3'UTR       27773535 chr10:1063500-1063501(+) m6A 3'UTR       27773535 chr10:1063953-1063954(+) m6A 3'UTR       - chr10:1065103-1065104(+) m6A 3'UTR       24981863//22608085 chr10:1065144-1065145(+) m6A 3'UTR       24981863//22608085 chr10:1065164-1065165(+) m6A 3'UTR       24981863//22608085 chr10:1065192-1065193(+) m6A 3'UTR       24981863//22608085 chr10:1065219-1065220(+) m6A 3'UTR       24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	GTPBP4	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: GTPBP4

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22291592	Target region	CDS
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).