Basic Information:

  VIRBase ID:  

VHID00281065

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          KDM4B:  NM_001370094     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	KDM4B
miRBase Accession/Entrez ID	MIMAT0000996	23030
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	JMJD2B//TDRD14B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KDM4B	chr19:4990155(+) A-I      intronic chr19:5139033(+) A-I      intronic chr19:5105709(+) A-I      intronic chr19:5105683(+) A-I      intronic chr19:4990180(+) A-I      intronic chr19:4990186(+) A-I      intronic chr19:4990203(+) A-I      intronic chr19:5006704(+) A-I      intronic chr19:5006705(+) A-I      intronic chr19:5006734(+) A-I      intronic chr19:5105513(+) A-I      intronic chr19:5105556(+) A-I      intronic chr19:5105578(+) A-I      intronic chr19:5030182(+) A-I      intronic chr19:5029047(+) A-I      intronic chr19:4987190(+) A-I      intronic chr19:4976102(+) A-I      intronic chr19:5021762(+) A-I      intronic chr19:5021744(+) A-I      intronic chr19:5021697(+) A-I      intronic chr19:5021544(+) A-I      intronic chr19:5021451(+) A-I      intronic chr19:5021331(+) A-I      intronic chr19:5110280(+) A-I      intronic chr19:5015627(+) A-I      intronic chr19:4980713(+) A-I      intronic chr19:5044624(+) A-I      intronic chr19:4993238(+) A-I      intronic chr19:5002882(+) A-I      intronic chr19:4976071(+) A-I      intronic chr19:4976101(+) A-I      intronic chr19:4976166(+) A-I      intronic chr19:4976180(+) A-I      intronic chr19:4976181(+) A-I      intronic chr19:4979040(+) A-I      intronic chr19:4979840(+) A-I      intronic chr19:4979842(+) A-I      intronic chr19:5101168(+) A-I      intronic chr19:5101161(+) A-I      intronic chr19:5101139(+) A-I      intronic chr19:5101079(+) A-I      intronic chr19:5101030(+) A-I      intronic chr19:5100661(+) A-I      intronic chr19:5100513(+) A-I      intronic chr19:4979899(+) A-I      intronic chr19:4980103(+) A-I      intronic chr19:5003371(+) A-I      intronic chr19:5003372(+) A-I      intronic chr19:5003398(+) A-I      intronic chr19:5044659(+) A-I      intronic chr19:5003471(+) A-I      intronic chr19:4993721(+) A-I      intronic chr19:5097365(+) A-I      intronic chr19:5097361(+) A-I      intronic chr19:4990280(+) A-I      intronic chr19:4990210(+) A-I      intronic chr19:4990209(+) A-I      intronic chr19:4990160(+) A-I      intronic chr19:5003472(+) A-I      intronic chr19:4990081(+) A-I      intronic chr19:4989429(+) A-I      intronic chr19:4989410(+) A-I      intronic chr19:4989374(+) A-I      intronic chr19:5006529(+) A-I      intronic chr19:5044685(+) A-I      intronic chr19:5089919(+) A-I      intronic chr19:5084906(+) A-I      intronic chr19:5084727(+) A-I      intronic chr19:5084702(+) A-I      intronic chr19:5084696(+) A-I      intronic chr19:5044658(+) A-I      intronic chr19:5061615(+) A-I      intronic chr19:5008038(+) A-I      intronic chr19:5007799(+) A-I      intronic chr19:5006725(+) A-I      intronic chr19:5006637(+) A-I      intronic chr19:5110342(+) A-I      intronic chr19:4982785(+) A-I      intronic chr19:4982760(+) A-I      intronic chr19:4990281(+) A-I      intronic chr19:4991415(+) A-I      intronic chr19:4992522(+) A-I      intronic chr19:4980552(+) A-I      intronic chr19:5006534(+) A-I      intronic chr19:4980590(+) A-I      intronic chr19:4980601(+) A-I      intronic chr19:4980609(+) A-I      intronic chr19:4980700(+) A-I      intronic chr19:4993244(+) A-I      intronic chr19:4993245(+) A-I      intronic chr19:4993268(+) A-I      intronic chr19:4993433(+) A-I      intronic chr19:4993722(+) A-I      intronic chr19:4993858(+) A-I      intronic chr19:4994328(+) A-I      intronic chr19:4994453(+) A-I      intronic chr19:4995419(+) A-I      intronic chr19:4990136(+) A-I      intronic chr19:4994467(+) A-I      intronic chr19:5149455(+) A-I      intronic chr19:5002855(+) A-I      intronic chr19:4992538(+) A-I      intronic chr19:5110227(+) A-I      intronic chr19:4993157(+) A-I      intronic chr19:5015628(+) A-I      intronic chr19:5030187(+) A-I      intronic chr19:4995473(+) A-I      intronic chr19:4992723(+) A-I      intronic chr19:5021063(+) A-I      intronic chr19:4990181(+) A-I      intronic chr19:4993820(+) A-I      intronic chr19:5110368(+) A-I      intronic chr19:5034034(+) A-I      intronic chr19:5138478(+) A-I      intronic chr19:5100603(+) A-I      intronic chr19:5143283(+) A-I      intronic chr19:4973339(+) A-I      intronic chr19:5101179(+) A-I      intronic chr19:5100578(+) A-I      intronic chr19:5105650(+) A-I      intronic chr19:5140667(+) A-I      intronic chr19:4990163(+) A-I      intronic chr19:4993274(+) A-I      intronic chr19:5029727(+) A-I      intronic chr19:5084048(+) A-I      intronic chr19:5101070(+) A-I      intronic chr19:5002272(+) A-I      intronic chr19:5143073(+) A-I      intronic chr19:4973223(+) A-I      intronic chr19:5054264(+) A-I      intronic chr19:5101440(+) A-I      intronic chr19:5100970(+) A-I      intronic chr19:4973300(+) A-I      intronic chr19:5084964(+) A-I      intronic chr19:4980104(+) A-I      intronic chr19:4975759(+) A-I      intronic chr19:5026446(+) A-I      intronic chr19:4990222(+) A-I      intronic chr19:5124859(+) A-I      intronic chr19:4990861(+) A-I      intronic chr19:4994407(+) A-I      intronic chr19:5015356(+) A-I      intronic chr19:4975743(+) A-I      intronic chr19:5100652(+) A-I      intronic chr19:5034065(+) A-I      intronic chr19:4993206(+) A-I      intronic chr19:5097331(+) A-I      intronic chr19:5110292(+) A-I      intronic chr19:5002944(+) A-I      intronic chr19:5023991(+) A-I      intronic chr19:5084926(+) A-I      intronic chr19:5024800(+) A-I      intronic chr19:5034905(+) A-I      intronic chr19:4994159(+) A-I      intronic chr19:4985224(+) A-I      intronic chr19:4976046(+) A-I      intronic chr19:5149409(+) A-I      intronic chr19:4990985(+) A-I      intronic chr19:5044610(+) A-I      intronic chr19:4982157(+) A-I      intronic chr19:4979196(+) A-I      intronic chr19:4978371(+) A-I      intronic chr19:4989683(+) A-I      intronic chr19:4974568(+) A-I      intronic chr19:4990120(+) A-I      intronic chr19:5034014(+) A-I      intronic chr19:5100556(+) A-I      intronic chr19:5023938(+) A-I      intronic chr19:4989442(+) A-I      intronic chr19:4993415(+) A-I      intronic chr19:5146831(+) A-I      intronic chr19:4980126(+) A-I      intronic chr19:4992482(+) A-I      intronic chr19:5100539(+) A-I      intronic chr19:4992598(+) A-I      intronic chr19:4974020(+) A-I      intronic chr19:5124647(+) A-I      intronic chr19:5023828(+) A-I      intronic chr19:5110425(+) A-I      intronic chr19:5139118(+) A-I      intronic chr19:5100615(+) A-I      intronic chr19:5105543(+) A-I      intronic chr19:5021745(+) A-I      intronic chr19:5034060(+) A-I      intronic chr19:5100487(+) A-I      intronic chr19:5084951(+) A-I      intronic chr19:4980673(+) A-I      intronic chr19:5084043(+) A-I      intronic chr19:5139135(+) A-I      intronic chr19:4980564(+) A-I      intronic chr19:5138569(+) A-I      intronic chr19:4973329(+) A-I      intronic chr19:5101031(+) A-I      intronic chr19:5097529(+) A-I      intronic chr19:4973231(+) A-I      intronic chr19:5045501(+) A-I      intronic chr19:5001183(+) A-I      intronic chr19:5029105(+) A-I      intronic chr19:5021453(+) A-I      intronic chr19:5021008(+) A-I      intronic chr19:5101174(+) A-I      intronic chr19:5146818(+) A-I      intronic chr19:4976113(+) A-I      intronic chr19:4994399(+) A-I      intronic chr19:4973380(+) A-I      intronic chr19:5045666(+) A-I      intronic chr19:5138644(+) A-I      intronic chr19:5110435(+) A-I      intronic chr19:5101071(+) A-I      intronic chr19:4980057(+) A-I      intronic chr19:5100689(+) A-I      intronic chr19:4993309(+) A-I      intronic chr19:4992563(+) A-I      intronic chr19:5110385(+) A-I      intronic chr19:4990972(+) A-I      intronic chr19:5101153(+) A-I      intronic chr19:5084991(+) A-I      intronic chr19:5101154(+) A-I      intronic chr19:4980600(+) A-I      intronic chr19:5100644(+) A-I      intronic chr19:5101081(+) A-I      intronic chr19:4975865(+) A-I      intronic chr19:5002851(+) A-I      intronic chr19:5139117(+) A-I      intronic chr19:5101072(+) A-I      intronic chr19:4990150(+) A-I      intronic chr19:4973383(+) A-I      intronic chr19:4993341(+) A-I      intronic chr19:5021786(+) A-I      intronic chr19:4979281(+) A-I      intronic chr19:4994231(+) A-I      intronic chr19:4974156(+) A-I      intronic chr19:5138984(+) A-I      intronic chr19:5060400(+) A-I      intronic chr19:4980615(+) A-I      intronic chr19:4974598(+) A-I      intronic chr19:4975690(+) A-I      intronic chr19:5110220(+) A-I      intronic chr19:4993211(+) A-I      intronic chr19:5045522(+) A-I      intronic chr19:5100532(+) A-I      intronic chr19:5139034(+) A-I      intronic chr19:5042273(+) A-I      intronic chr19:5105577(+) A-I      intronic chr19:4975833(+) A-I      intronic chr19:4974596(+) A-I      intronic chr19:5089940(+) A-I      intronic chr19:4982885(+) A-I      intronic chr19:4994495(+) A-I      intronic chr19:4975629(+) A-I      intronic chr19:5143223(+) A-I      intronic chr19:5021749(+) A-I      intronic chr19:5138642(+) A-I      intronic chr19:4989489(+) A-I      intronic chr19:5006713(+) A-I      intronic chr19:4980535(+) A-I      intronic chr19:5140647(+) A-I      intronic chr19:4976110(+) A-I      intronic chr19:5024862(+) A-I      intronic chr19:5100474(+) A-I      intronic chr19:5039355(+) A-I      intronic chr19:4979973(+) A-I      intronic chr19:5101493(+) A-I      intronic chr19:5097498(+) A-I      intronic chr19:5002035(+) A-I      intronic chr19:4990258(+) A-I      intronic chr19:5110226(+) A-I      intronic chr19:4979956(+) A-I      intronic chr19:5029103(+) A-I      intronic chr19:5097362(+) A-I      intronic chr19:5002825(+) A-I      intronic chr19:5021059(+) A-I      intronic chr19:4987142(+) A-I      intronic chr19:5015404(+) A-I      intronic chr19:4994167(+) A-I      intronic chr19:4989803(+) A-I      intronic chr19:5143259(+) A-I      intronic chr19:5101113(+) A-I      intronic chr19:4979936(+) A-I      intronic chr19:5138563(+) A-I      intronic chr19:4990874(+) A-I      intronic chr19:4980674(+) A-I      intronic chr19:5084051(+) A-I      intronic chr19:4979173(+) A-I      intronic chr19:5101086(+) A-I      intronic chr19:5002555(+) A-I      intronic chr19:4974099(+) A-I      intronic chr19:5149385(+) A-I      intronic chr19:5039368(+) A-I      intronic chr19:5149361(+) A-I      intronic chr19:4973420(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KDM4B	chr19:5139117(+) A-I intron -    22327324 chr19:4976113(+) A-G intron -    22484847 chr19:4993383(+) A-G intron -    22484847 chr19:5097356(+) A-G intron -    22484847 chr19:5100591(+) A-G intron -    22484847 chr19:5100603(+) A-G intron -    22484847 chr19:5101086(+) A-G intron -    22484847 chr19:5101113(+) A-G intron -    22484847 chr19:5101414(+) A-G intron -    22484847 chr19:5105543(+) A-G intron -    22484847 chr19:5105577(+) A-G intron -    22484847 chr19:5110262(+) A-G intron -    22484847 chr19:5110281(+) A-G intron -    22484847 chr19:5139034(+) A-G intron -    22484847 chr19:5139051(+) A-G intron -    22484847 chr19:5139117(+) A-G intron -    22484847 chr19:5139118(+) A-G intron -    22484847 chr19:5139119(+) A-G intron -    22484847 chr19:5140647(+) A-G intron -    22484847 chr19:5146831(+) A-G intron -    22484847 chr19:5153054(+) C-A intron -    22484847 chr19:5153055(+) T-A intron -    22484847 chr19:5153056(+) C-A intron -    22484847 chr19:5153057(+) C-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KDM4B	chr19:5016334-5016335(+) m6A 5'UTR//intron       24284625 chr19:5032914-5032915(+) m6A CDS       24284625 chr19:5032929-5032930(+) m6A CDS       24284625 chr19:5032980-5032981(+) m6A CDS       24284625 chr19:5077457-5077458(+) m1A CDS//exon       26863196 chr19:5077984-5077985(+) m6A exon//intron       - chr19:5077991-5077992(+) m6A exon//intron       - chr19:5078044-5078045(+) m6A exon//intron       - chr19:5078253-5078254(+) m6A exon//intron       - chr19:5078389-5078390(+) m6A exon//intron       - chr19:5078484-5078485(+) m6A exon//intron       - chr19:5078712-5078713(+) m6A exon//intron       - chr19:5078764-5078765(+) m6A exon//intron       - chr19:5078941-5078942(+) m6A exon//intron       - chr19:5078969-5078970(+) m6A exon//intron       - chr19:5080906-5080907(+) m6A exon//intron       25456834 chr19:5080915-5080916(+) m6A exon//intron       25456834 chr19:5080946-5080947(+) m6A exon//intron       25456834 chr19:5080988-5080989(+) m6A exon//intron       25456834 chr19:5110726-5110727(+) m6A CDS//exon       - chr19:5110741-5110742(+) m6A CDS//exon       - chr19:5111977-5111978(+) m6A 3'UTR//intron       24981863 chr19:5112064-5112065(+) m6A 3'UTR//intron       24981863 chr19:5112253-5112254(+) m6A 3'UTR//intron       24981863 chr19:5112272-5112273(+) m6A 3'UTR//intron       24981863 chr19:5112280-5112281(+) m6A 3'UTR//intron       24981863 chr19:5112292-5112293(+) m6A 3'UTR//intron       24981863 chr19:5112300-5112301(+) m6A 3'UTR//intron       24981863 chr19:5112331-5112332(+) m6A 3'UTR//intron       24981863 chr19:5113332-5113333(+) m6A 3'UTR//intron       24981863 chr19:5119148-5119149(+) m6A CDS//exon//intron       24981863 chr19:5119165-5119166(+) m6A CDS//exon//intron       24981863 chr19:5119182-5119183(+) m6A CDS//exon//intron       24981863 chr19:5119190-5119191(+) Tm CDS//exon//intron       - chr19:5119210-5119211(+) m6A CDS//exon//intron       24209618//25456834//24981863 chr19:5119707-5119708(+) m6A CDS//exon       24209618//25456834//24981863 chr19:5131136-5131137(+) m1A CDS//exon       26863196 chr19:5131459-5131460(+) m6A CDS//exon       - chr19:5131529-5131530(+) m6A CDS//exon       - chr19:5133971-5133972(+) m6A CDS//exon       - chr19:5135479-5135480(+) m6A CDS//exon       24284625 chr19:5135523-5135524(+) m6A CDS//exon       24284625 chr19:5140547-5140548(+) m6A 3'UTR//intron       - chr19:5140569-5140570(+) m6A 3'UTR//intron       - chr19:5140594-5140595(+) m6A 3'UTR//intron       - chr19:5140643-5140644(+) m6A 3'UTR//intron       - chr19:5141021-5141022(+) m6A 3'UTR//intron       25456834 chr19:5141056-5141057(+) m6A 3'UTR//intron       25456834 chr19:5141070-5141071(+) m6A 3'UTR//intron       25456834 chr19:5151442-5151443(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr19:5151460-5151461(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chr19:5151523-5151524(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr19:5151695-5151696(+) m6A 3'UTR//exon       24209618//25456834//24981863//27371828//22575960//22608085 chr19:5151768-5151769(+) m6A 3'UTR//exon       24209618//25456834//24981863//27371828 chr19:5152002-5152003(+) m6A 3'UTR       - chr19:5152078-5152079(+) m6A 3'UTR       - chr19:5152095-5152096(+) m6A 3'UTR       - chr19:5152531-5152532(+) Cm 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	KDM4B	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: KDM4B

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).