Basic Information:

  VIRBase ID:  

VHID00281002

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          AKAP11:  NM_016248     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	AKAP11
miRBase Accession/Entrez ID	MIMAT0000996	11215
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AKAP-11//AKAP220//PPP1R44//PRKA11

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	AKAP11	chr13:42848624(+) A-I      intronic chr13:42848619(+) A-I      intronic chr13:42848644(+) A-I      intronic chr13:42848661(+) A-I      intronic chr13:42848600(+) A-I      intronic chr13:42850603(+) A-I      intronic chr13:42891131(+) A-I      intronic chr13:42888323(+) A-I      intronic chr13:42888475(+) A-I      intronic chr13:42891197(+) A-I      intronic chr13:42888496(+) A-I      intronic chr13:42891248(+) A-I      intronic chr13:42888331(+) A-I      intronic chr13:42891153(+) A-I      intronic chr13:42891249(+) A-I      intronic chr13:42888460(+) A-I      intronic chr13:42848823(+) A-I      intronic chr13:42848755(+) A-I      intronic chr13:42861602(+) A-I      intronic chr13:42848618(+) A-I      intronic chr13:42888461(+) A-I      intronic chr13:42888434(+) A-I      intronic chr13:42850446(+) A-I      intronic chr13:42891043(+) A-I      intronic chr13:42868720(+) A-I      intronic chr13:42850602(+) A-I      intronic chr13:42848699(+) A-I      intronic chr13:42850430(+) A-I      intronic chr13:42850500(+) A-I      intronic chr13:42888416(+) A-I      intronic chr13:42888501(+) A-I      intronic chr13:42888326(+) A-I      intronic chr13:42850591(+) A-I      intronic chr13:42868811(+) A-I      intronic chr13:42848666(+) A-I      intronic chr13:42888502(+) A-I      intronic chr13:42891045(+) A-I      intronic chr13:42888420(+) A-I      intronic chr13:42891129(+) A-I      intronic chr13:42891195(+) A-I      intronic chr13:42850565(+) A-I      intronic chr13:42888423(+) A-I      intronic chr13:42848564(+) A-I      intronic chr13:42868799(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	AKAP11	chr13:42887184(+) A-G exon CDS    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	AKAP11	chr13:42872818-42872819(+) m6A CDS       24284625 chr13:42872911-42872912(+) m6A CDS       24284625//22608085 chr13:42873504-42873505(+) m6A CDS       24284625//22608085 chr13:42873569-42873570(+) m6A CDS       24284625//22608085 chr13:42873601-42873602(+) m6A CDS       24284625//24981863//22608085 chr13:42873622-42873623(+) m6A CDS       24284625//24981863//22608085 chr13:42873652-42873653(+) m6A CDS       24284625//24981863//22608085 chr13:42873661-42873662(+) m6A CDS       24284625//24981863//22608085 chr13:42873677-42873678(+) m6A CDS       24284625//24981863//22608085 chr13:42873710-42873711(+) m6A CDS       24284625//24981863//22608085 chr13:42873770-42873771(+) m6A CDS       24284625//22608085 chr13:42873877-42873878(+) m6A CDS       24284625//24981863//22608085 chr13:42873927-42873928(+) m6A CDS       24284625//24981863//22608085 chr13:42873973-42873974(+) m6A CDS       24284625//24981863//22608085 chr13:42873979-42873980(+) m6A CDS       24284625//24981863//22608085 chr13:42873992-42873993(+) m6A CDS       24284625//24981863//22608085 chr13:42874051-42874052(+) m6A CDS       24284625//24981863//22608085 chr13:42874138-42874139(+) m6A CDS       24284625//22608085 chr13:42874350-42874351(+) m6A CDS       24284625//24981863//22608085 chr13:42874438-42874439(+) m6A CDS       24284625//24981863//22608085 chr13:42874454-42874455(+) m6A CDS       24981863//22608085 chr13:42874476-42874477(+) m6A CDS       24981863//22608085 chr13:42874584-42874585(+) m6A CDS       24981863//22608085 chr13:42875355-42875356(+) m6A CDS       22608085 chr13:42875404-42875405(+) m6A CDS       22608085 chr13:42875434-42875435(+) m6A CDS       24981863//22608085 chr13:42875540-42875541(+) m6A CDS       24284625//24981863//22608085 chr13:42875624-42875625(+) m6A CDS       24284625//24981863//26404942//22608085 chr13:42875688-42875689(+) m6A CDS       24284625//24981863//26404942//22608085 chr13:42875725-42875726(+) m6A CDS       24284625//24981863//22608085 chr13:42875945-42875946(+) m6A CDS       24284625//24981863//22608085 chr13:42876064-42876065(+) m6A CDS       24284625//22608085 chr13:42876072-42876073(+) m6A CDS       24284625//22608085 chr13:42876145-42876146(+) m6A CDS       24284625//22608085 chr13:42876159-42876160(+) m6A CDS       24284625//24981863//22608085 chr13:42876340-42876341(+) m6A CDS       24284625//22608085 chr13:42876376-42876377(+) m6A CDS       22608085 chr13:42876943-42876944(+) m6A CDS       22608085 chr13:42877037-42877038(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr13:42877094-42877095(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr13:42877105-42877106(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr13:42877122-42877123(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr13:42877146-42877147(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr13:42877156-42877157(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr13:42877196-42877197(+) m6A CDS       24284625//25456834//24981863//22608085 chr13:42877208-42877209(+) m6A CDS       24284625//24981863//22608085 chr13:42877482-42877483(+) m6A CDS       24284625//24209618//24981863//22608085 chr13:42877504-42877505(+) m6A CDS       24284625//24209618//24981863//22608085 chr13:42877577-42877578(+) m6A CDS       24284625//25456834//24981863//22608085 chr13:42877593-42877594(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr13:42877663-42877664(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:42877705-42877706(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr13:42877915-42877916(+) m6A CDS       24981863 chr13:42887238-42887239(+) m6A CDS       24981863 chr13:42887262-42887263(+) m6A CDS       24981863//22575960 chr13:42888035-42888036(+) m6A CDS       24981863//22575960 chr13:42891683-42891684(+) m6A CDS       24981863 chr13:42891726-42891727(+) m6A CDS       - chr13:42891784-42891785(+) m6A CDS       - chr13:42893231-42893232(+) m6A CDS       - chr13:42894550-42894551(+) m6A 3'UTR       - chr13:42894574-42894575(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	AKAP11	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: AKAP11

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).