Basic Information:

  VIRBase ID:  

VHID00280901

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          ARFGEF1:  NM_006421     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	ARFGEF1
miRBase Accession/Entrez ID	MIMAT0000996	10565
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARFGEP1//BIG1//P200

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARFGEF1	chr8:68238271(-) A-I      intronic chr8:68238268(-) A-I      intronic chr8:68238217(-) A-I      intronic chr8:68236510(-) A-I      intronic chr8:68236071(-) A-I      intronic chr8:68236066(-) A-I      intronic chr8:68235430(-) A-I      intronic chr8:68235251(-) A-I      intronic chr8:68117470(-) A-I      intronic chr8:68117492(-) A-I      intronic chr8:68117496(-) A-I      intronic chr8:68117529(-) A-I      intronic chr8:68119006(-) A-I      intronic chr8:68119007(-) A-I      intronic chr8:68119025(-) A-I      intronic chr8:68235235(-) A-I      intronic chr8:68234812(-) A-I      intronic chr8:68234740(-) A-I      intronic chr8:68233967(-) A-I      intronic chr8:68233962(-) A-I      intronic chr8:68233872(-) A-I      intronic chr8:68233870(-) A-I      intronic chr8:68233863(-) A-I      intronic chr8:68233763(-) A-I      intronic chr8:68233756(-) A-I      intronic chr8:68233743(-) A-I      intronic chr8:68233731(-) A-I      intronic chr8:68233159(-) A-I      intronic chr8:68233114(-) A-I      intronic chr8:68233110(-) A-I      intronic chr8:68233096(-) A-I      intronic chr8:68232947(-) A-I      intronic chr8:68219145(-) A-I      intronic chr8:68219137(-) A-I      intronic chr8:68219086(-) A-I      intronic chr8:68219085(-) A-I      intronic chr8:68219065(-) A-I      intronic chr8:68119039(-) A-I      intronic chr8:68119069(-) A-I      intronic chr8:68119085(-) A-I      intronic chr8:68233075(-) A-I      intronic chr8:68217815(-) A-I      intronic chr8:68217801(-) A-I      intronic chr8:68217752(-) A-I      intronic chr8:68117484(-) A-I      intronic chr8:68118994(-) A-I      intronic chr8:68118995(-) A-I      intronic chr8:68119097(-) A-I      intronic chr8:68119109(-) A-I      intronic chr8:68217746(-) A-I      intronic chr8:68185099(-) A-I      intronic chr8:68185098(-) A-I      intronic chr8:68184604(-) A-I      intronic chr8:68184591(-) A-I      intronic chr8:68184530(-) A-I      intronic chr8:68184498(-) A-I      intronic chr8:68171984(-) A-I      intronic chr8:68169535(-) A-I      intronic chr8:68169431(-) A-I      intronic chr8:68156753(-) A-I      intronic chr8:68156582(-) A-I      intronic chr8:68156416(-) A-I      intronic chr8:68156310(-) A-I      intronic chr8:68156249(-) A-I      intronic chr8:68135649(-) A-I      intronic chr8:68135636(-) A-I      intronic chr8:68135604(-) A-I      intronic chr8:68135601(-) A-I      intronic chr8:68124519(-) A-I      intronic chr8:68238381(-) A-I      intronic chr8:68124499(-) A-I      intronic chr8:68124458(-) A-I      intronic chr8:68124456(-) A-I      intronic chr8:68124455(-) A-I      intronic chr8:68185266(-) A-I      intronic chr8:68245307(-) A-I      intronic chr8:68241600(-) A-I      intronic chr8:68171600(-) A-I      intronic chr8:68241597(-) A-I      intronic chr8:68239649(-) A-I      intronic chr8:68215825(-) A-I      intronic chr8:68215827(-) A-I      intronic chr8:68215837(-) A-I      intronic chr8:68228898(-) A-I      intronic chr8:68249122(-) A-I      intronic chr8:68228911(-) A-I      intronic chr8:68228913(-) A-I      intronic chr8:68228914(-) A-I      intronic chr8:68228937(-) A-I      intronic chr8:68228968(-) A-I      intronic chr8:68239613(-) A-I      intronic chr8:68245343(-) A-I      intronic chr8:68245344(-) A-I      intronic chr8:68245463(-) A-I      intronic chr8:68246222(-) A-I      intronic chr8:68246223(-) A-I      intronic chr8:68246263(-) A-I      intronic chr8:68246295(-) A-I      intronic chr8:68246314(-) A-I      intronic chr8:68247446(-) A-I      intronic chr8:68247449(-) A-I      intronic chr8:68247452(-) A-I      intronic chr8:68247512(-) A-I      intronic chr8:68247513(-) A-I      intronic chr8:68247520(-) A-I      intronic chr8:68247541(-) A-I      intronic chr8:68249123(-) A-I      intronic chr8:68249144(-) A-I      intronic chr8:68249352(-) A-I      intronic chr8:68185273(-) A-I      intronic chr8:68214216(-) A-I      intronic chr8:68214224(-) A-I      intronic chr8:68215683(-) A-I      intronic chr8:68216997(-) A-I      intronic chr8:68217032(-) A-I      intronic chr8:68217707(-) A-I      intronic chr8:68217720(-) A-I      intronic chr8:68215209(-) A-I      intronic chr8:68247370(-) A-I      intronic chr8:68216870(-) A-I      intronic chr8:68233866(-) A-I      intronic chr8:68183240(-) A-I      intronic chr8:68234939(-) A-I      intronic chr8:68171953(-) A-I      intronic chr8:68253756(-) A-I      intronic chr8:68124564(-) A-I      intronic chr8:68246209(-) A-I      intronic chr8:68215780(-) A-I      intronic chr8:68124591(-) A-I      intronic chr8:68215783(-) A-I      intronic chr8:68216859(-) A-I      intronic chr8:68237330(-) A-I      intronic chr8:68156784(-) A-I      intronic chr8:68228839(-) A-I      intronic chr8:68219151(-) A-I      intronic chr8:68217800(-) A-I      intronic chr8:68184534(-) A-I      intronic chr8:68215092(-) A-I      intronic chr8:68129423(-) A-I      intronic chr8:68184576(-) A-I      intronic chr8:68171735(-) A-I      intronic chr8:68237212(-) A-I      intronic chr8:68185230(-) A-I      intronic chr8:68124355(-) A-I      intronic chr8:68233031(-) A-I      intronic chr8:68253578(-) A-I      intronic chr8:68248049(-) A-I      intronic chr8:68216844(-) A-I      intronic chr8:68249198(-) A-I      intronic chr8:68215066(-) A-I      intronic chr8:68209771(-) A-I      intronic chr8:68210140(-) A-I      intronic chr8:68248164(-) A-I      intronic chr8:68253750(-) A-I      intronic chr8:68124423(-) A-I      intronic chr8:68236502(-) A-I      intronic chr8:68245376(-) A-I      intronic chr8:68171736(-) A-I      intronic chr8:68210198(-) A-I      intronic chr8:68238312(-) A-I      intronic chr8:68124560(-) A-I      intronic chr8:68235249(-) A-I      intronic chr8:68234845(-) A-I      intronic chr8:68234688(-) A-I      intronic chr8:68096915(-) A-I      intronic chr8:68237289(-) A-I      intronic chr8:68239713(-) A-I      intronic chr8:68241575(-) A-I      intronic chr8:68236466(-) A-I      intronic chr8:68238339(-) A-I      intronic chr8:68248165(-) A-I      intronic chr8:68234883(-) A-I      intronic chr8:68114542(-) A-I      intronic chr8:68156258(-) A-I      intronic chr8:68156698(-) A-I      intronic chr8:68156284(-) A-I      intronic chr8:68231096(-) A-I      intronic chr8:68156794(-) A-I      intronic chr8:68219182(-) A-I      intronic chr8:68184596(-) A-I      intronic chr8:68246324(-) A-I      intronic chr8:68215059(-) A-I      intronic chr8:68208984(-) A-I      intronic chr8:68238402(-) A-I      intronic chr8:68185328(-) A-I      intronic chr8:68236096(-) A-I      intronic chr8:68171958(-) A-I      intronic chr8:68156743(-) A-I      intronic chr8:68238386(-) A-I      intronic chr8:68184454(-) A-I      intronic chr8:68156304(-) A-I      intronic chr8:68230098(-) A-I      intronic chr8:68253566(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ARFGEF1	chr8:68117467(-) A-I intron -    15258596 chr8:68117482(-) A-I intron -    15258596 chr8:68117503(-) A-I intron -    15258596 chr8:68117515(-) A-I intron -    15258596   //21960545 chr8:68117537(-) A-I intron -    15258596 chr8:68166076(-) A-I intron -    19478186 chr8:68117511(-) A-I intron -    21960545 chr8:68117556(-) A-I intron -    21960545 chr8:68117563(-) A-I intron -    21960545 chr8:68118974(-) A-I intron -    21960545 chr8:68119006(-) A-I intron -    21960545 chr8:68119007(-) A-I intron -    21960545 chr8:68119043(-) A-I intron -    21960545 chr8:68119068(-) A-I intron -    21960545 chr8:68134447(-) G-A intron -    22484847 chr8:68118374(-) T-C intron -    22484847 chr8:68118644(-) A-T intron -    22484847 chr8:68118645(-) A-T intron -    22484847 chr8:68118648(-) T-A intron -    22484847 chr8:68122282(-) G-A intron -    22484847 chr8:68123177(-) T-C intron -    22484847 chr8:68123293(-) G-T intron -    22484847 chr8:68123579(-) A-T intron -    22484847 chr8:68123580(-) G-T intron -    22484847 chr8:68124564(-) A-G intron -    22484847 chr8:68156284(-) A-G intron -    22484847 chr8:68156304(-) A-G intron -    22484847 chr8:68156365(-) A-G intron -    22484847 chr8:68156415(-) A-G intron -    22484847 chr8:68156641(-) A-G intron -    22484847 chr8:68156698(-) A-G intron -    22484847 chr8:68156743(-) A-G intron -    22484847 chr8:68156794(-) A-G intron -    22484847 chr8:68156801(-) A-G intron -    22484847 chr8:68162032(-) G-A intron -    22484847 chr8:68171928(-) A-G intron -    22484847 chr8:68171953(-) A-G intron -    22484847 chr8:68171958(-) A-G intron -    22484847 chr8:68184534(-) A-G intron -    22484847 chr8:68184540(-) A-G intron -    22484847 chr8:68184596(-) A-G intron -    22484847 chr8:68184606(-) A-G intron -    22484847 chr8:68185230(-) A-G intron -    22484847 chr8:68185328(-) A-G intron -    22484847 chr8:68208984(-) A-G intron -    22484847 chr8:68209731(-) A-G intron -    22484847 chr8:68209782(-) A-G intron -    22484847 chr8:68217800(-) A-G intron -    22484847 chr8:68219151(-) A-G intron -    22484847 chr8:68219182(-) A-G intron -    22484847 chr8:68219187(-) A-G intron -    22484847 chr8:68227225(-) T-C intron -    22484847 chr8:68230474(-) C-T intron -    22484847 chr8:68233031(-) A-G intron -    22484847 chr8:68233034(-) A-G intron -    22484847 chr8:68233113(-) A-G intron -    22484847 chr8:68233177(-) A-G intron -    22484847 chr8:68233928(-) A-G intron -    22484847 chr8:68236514(-) A-G intron -    22484847 chr8:68237330(-) A-G intron -    22484847 chr8:68238312(-) A-G intron -    22484847 chr8:68238339(-) A-G intron -    22484847 chr8:68238386(-) A-G intron -    22484847 chr8:68238389(-) A-G intron -    22484847 chr8:68238402(-) A-G intron -    22484847 chr8:68239690(-) A-G intron -    22484847 chr8:68246206(-) A-G intron -    22484847 chr8:68246209(-) A-G intron -    22484847 chr8:68246288(-) A-G intron -    22484847 chr8:68119104(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARFGEF1	chr8:68110287-68110288(-) m6A 3'UTR//exon//intron       24981863//27773535 chr8:68110293-68110294(-) m6A 3'UTR//exon//intron       24981863//27773535 chr8:68110335-68110336(-) m6A 3'UTR//exon//intron       24981863//27773535 chr8:68110827-68110828(-) m6A 3'UTR//exon//intron       24981863//26404942//27773535//22608085 chr8:68110847-68110848(-) m6A 3'UTR//exon//intron       24981863//26404942//27773535//22608085 chr8:68110860-68110861(-) m6A 3'UTR//exon//intron       24209618//24981863//27773535//22608085 chr8:68110943-68110944(-) m6A 3'UTR//exon//intron       24284625//24981863//27773535//22608085 chr8:68111025-68111026(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//22608085 chr8:68111162-68111163(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr8:68111178-68111179(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr8:68111189-68111190(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr8:68111195-68111196(-) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr8:68111264-68111265(-) m6A CDS//exon//intron       24284625//24981863//27773535//27371828//22608085 chr8:68138401-68138402(-) m6A CDS       - chr8:68139389-68139390(-) m6A CDS       - chr8:68139402-68139403(-) m6A CDS       - chr8:68163622-68163623(-) m6A CDS       27773535 chr8:68163659-68163660(-) m6A CDS       24981863//27773535 chr8:68163668-68163669(-) m6A CDS       24981863//27773535 chr8:68165689-68165690(-) m6A CDS       24981863//27773535 chr8:68165716-68165717(-) m6A CDS       24981863//27773535 chr8:68165724-68165725(-) m6A CDS       24981863//27773535 chr8:68165792-68165793(-) m6A CDS       24981863//27773535 chr8:68165833-68165834(-) m6A CDS       24981863//27773535 chr8:68172053-68172054(-) m6A CDS       24981863 chr8:68172118-68172119(-) m6A CDS       24981863//27773535 chr8:68172148-68172149(-) m6A CDS       24981863//27773535 chr8:68178254-68178255(-) m6A CDS       24981863//27773535 chr8:68178293-68178294(-) m6A CDS       24981863//27773535 chr8:68178384-68178385(-) m6A CDS       24981863//27773535 chr8:68189641-68189642(-) m6A CDS       27773535 chr8:68189677-68189678(-) m6A CDS       24981863//27773535 chr8:68200203-68200204(-) m6A CDS       24981863//27773535 chr8:68200224-68200225(-) m6A CDS       24981863//27773535 chr8:68200236-68200237(-) m6A CDS       24981863//27773535//22608085 chr8:68200263-68200264(-) m6A CDS       24981863//27773535//22608085 chr8:68204115-68204116(-) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr8:68204206-68204207(-) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr8:68204217-68204218(-) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr8:68204240-68204241(-) m6A CDS       24284625//24981863//26404942//27773535//22608085 chr8:68204343-68204344(-) m6A CDS       24284625//27773535//22608085 chr8:68208672-68208673(-) m6A CDS       24284625//27773535//22608085 chr8:68208730-68208731(-) m6A CDS       27773535 chr8:68208775-68208776(-) m6A CDS       27773535 chr8:68208796-68208797(-) m6A CDS       27773535 chr8:68211475-68211476(-) m6A CDS       27773535 chr8:68213537-68213538(-) m6A CDS       27773535 chr8:68213556-68213557(-) m6A CDS       27773535 chr8:68214675-68214676(-) m6A CDS       24981863//27773535 chr8:68214683-68214684(-) m6A CDS       24981863//27773535 chr8:68255496-68255497(-) m6A CDS       27773535 chr8:68255718-68255719(-) m6A 5'UTR//intron       24981863//27773536 chr8:68255863-68255864(-) m6A 5'UTR       27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	ARFGEF1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: ARFGEF1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).