Basic Information:

  VIRBase ID:  

VHID00280744

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          CEP57:  NM_014679     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	CEP57
miRBase Accession/Entrez ID	MIMAT0000996	9702
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	MVA2//PIG8//TSP57

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CEP57	chr11:95562171(+) A-I      intronic chr11:95547407(+) A-I      intronic chr11:95530515(+) A-I      intronic chr11:95557325(+) A-I      intronic chr11:95558873(+) A-I      intronic chr11:95547346(+) A-I      intronic chr11:95547358(+) A-I      intronic chr11:95547310(+) A-I      intronic chr11:95557354(+) A-I      intronic chr11:95547410(+) A-I      intronic chr11:95533586(+) A-I      intronic chr11:95548871(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CEP57	chr11:95547407(+) A-G intron -    22484847 chr11:95553570(+) C-T intron -    22484847 chr11:95557354(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CEP57	chr11:95523259-95523260(+) m6A 5'UTR       24284625//27773535 chr11:95546144-95546145(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr11:95546178-95546179(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr11:95546193-95546194(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr11:95546222-95546223(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr11:95546230-95546231(+) Am 3'UTR//CDS//exon       - chr11:95546683-95546684(+) m6A 3'UTR//CDS//exon       27773535 chr11:95546732-95546733(+) m6A 3'UTR//CDS//exon       27773535 chr11:95546749-95546750(+) m6A 3'UTR//CDS//exon       27773535 chr11:95548304-95548305(+) m6A exon//intron       27773535 chr11:95551039-95551040(+) m6A 3'UTR//CDS//exon       27773535 chr11:95552016-95552017(+) m6A 3'UTR//CDS       24981863 chr11:95552031-95552032(+) m6A 3'UTR//CDS       24981863 chr11:95555040-95555041(+) m6A 3'UTR//CDS//intron       24981863 chr11:95555052-95555053(+) m6A 3'UTR//CDS//intron       24981863 chr11:95555060-95555061(+) m6A 3'UTR//CDS//intron       24981863 chr11:95562371-95562372(+) m6A 3'UTR//CDS//exon       - chr11:95562398-95562399(+) m6A 3'UTR//CDS//exon       - chr11:95562406-95562407(+) m6A 3'UTR//CDS//exon       - chr11:95564197-95564198(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr11:95564243-95564244(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:95564262-95564263(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:95564291-95564292(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:95564317-95564318(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:95564323-95564324(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr11:95564364-95564365(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942//27773535//22608085 chr11:95565017-95565018(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	CEP57	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: CEP57

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22291592	Target region	CDS
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).