Basic Information:

  VIRBase ID:  

VHID00280737

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.2202

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          EIF5B:  NM_015904     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	EIF5B
miRBase Accession/Entrez ID	MIMAT0000996	9669
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	IF2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF5B	chr2:99990542(+) A-I      intronic chr2:99961906(+) A-I      intronic chr2:99961836(+) A-I      intronic chr2:99961136(+) A-I      intronic chr2:99961097(+) A-I      intronic chr2:99963173(+) A-I      intronic chr2:99960666(+) A-I      intronic chr2:99960523(+) A-I      intronic chr2:99960511(+) A-I      intronic chr2:99960451(+) A-I      intronic chr2:99960234(+) A-I      intronic chr2:99960226(+) A-I      intronic chr2:99959331(+) A-I      intronic chr2:99956108(+) A-I      intronic chr2:99956052(+) A-I      intronic chr2:99956040(+) A-I      intronic chr2:99979387(+) A-I      intronic chr2:99979498(+) A-I      intronic chr2:99988857(+) A-I      intronic chr2:99988865(+) A-I      intronic chr2:99988866(+) A-I      intronic chr2:99990587(+) A-I      intronic chr2:99961914(+) A-I      intronic chr2:99963195(+) A-I      intronic chr2:99963200(+) A-I      intronic chr2:99963244(+) A-I      intronic chr2:99963612(+) A-I      intronic chr2:99963634(+) A-I      intronic chr2:99961910(+) A-I      intronic chr2:99963163(+) A-I      intronic chr2:99962299(+) A-I      intronic chr2:99968294(+) A-I      intronic chr2:99962237(+) A-I      intronic chr2:99962036(+) A-I      intronic chr2:99961977(+) A-I      intronic chr2:99968410(+) A-I      intronic chr2:99978986(+) A-I      intronic chr2:99979006(+) A-I      intronic chr2:99979015(+) A-I      intronic chr2:99979041(+) A-I      intronic chr2:99979247(+) A-I      intronic chr2:99979347(+) A-I      intronic chr2:99979351(+) A-I      intronic chr2:99962206(+) A-I      intronic chr2:99978913(+) A-I      intronic chr2:99974792(+) A-I      intronic chr2:99960025(+) A-I      intronic chr2:99960534(+) A-I      intronic chr2:99961874(+) A-I      intronic chr2:99979505(+) A-I      intronic chr2:99978976(+) A-I      intronic chr2:99961120(+) A-I      intronic chr2:99979496(+) A-I      intronic chr2:99963679(+) A-I      intronic chr2:99972095(+) A-I      intronic chr2:99963495(+) A-I      intronic chr2:99975681(+) A-I      intronic chr2:99961187(+) A-I      intronic chr2:99961065(+) A-I      intronic chr2:99960143(+) A-I      intronic chr2:99960095(+) A-I      intronic chr2:99960939(+) A-I      intronic chr2:99961152(+) A-I      intronic chr2:99978910(+) A-I      intronic chr2:99979283(+) A-I      intronic chr2:99960162(+) A-I      intronic chr2:99960094(+) A-I      intronic chr2:99974669(+) A-I      intronic chr2:99962152(+) A-I      intronic chr2:99968254(+) A-I      intronic chr2:99989062(+) A-I      intronic chr2:99961966(+) A-I      intronic chr2:99961162(+) A-I      intronic chr2:99960026(+) A-I      intronic chr2:99960007(+) A-I      intronic chr2:100001579(+) A-I      intronic chr2:99960953(+) A-I      intronic chr2:99974659(+) A-I      intronic chr2:99959332(+) A-I      intronic chr2:99960156(+) A-I      intronic chr2:99979278(+) A-I      intronic chr2:99961000(+) A-I      intronic chr2:99960009(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EIF5B	chr2:99992274(+) A-I intron -    21960545 chr2:99959332(+) A-G intron -    22484847 chr2:99960007(+) A-G intron -    22484847 chr2:99960009(+) A-G intron -    22484847 chr2:99960026(+) A-G intron -    22484847 chr2:99960094(+) A-G intron -    22484847 chr2:99960095(+) A-G intron -    22484847 chr2:99960143(+) A-G intron -    22484847 chr2:99960156(+) A-G intron -    22484847 chr2:99960162(+) A-G intron -    22484847 chr2:99960534(+) A-G intron -    22484847 chr2:99960589(+) A-G intron -    22484847 chr2:99960939(+) A-G intron -    22484847 chr2:99960953(+) A-G intron -    22484847 chr2:99961065(+) A-G intron -    22484847 chr2:99961078(+) C-T intron -    22484847 chr2:99961089(+) A-G intron -    22484847 chr2:99961109(+) A-G intron -    22484847 chr2:99961120(+) A-G intron -    22484847 chr2:99961135(+) A-G intron -    22484847 chr2:99961152(+) A-G intron -    22484847 chr2:99961162(+) A-G intron -    22484847 chr2:99962206(+) A-G intron -    22484847 chr2:99963679(+) A-G intron -    22484847 chr2:99968254(+) A-G intron -    22484847 chr2:99972163(+) T-C intron -    22484847 chr2:99974655(+) A-G intron -    22484847 chr2:99974669(+) A-G intron -    22484847 chr2:99975789(+) G-C intron -    22484847 chr2:99978904(+) A-G intron -    22484847 chr2:99978910(+) A-G intron -    22484847 chr2:99978912(+) A-G intron -    22484847 chr2:99978913(+) A-G intron -    22484847 chr2:99978976(+) A-G intron -    22484847 chr2:99979278(+) A-G intron -    22484847 chr2:99979283(+) A-G intron -    22484847 chr2:99979496(+) A-G intron -    22484847 chr2:99983908(+) C-T intron -    22484847 chr2:100001573(+) A-G intron -    22484847 chr2:100001579(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF5B	chr2:100006838-100006839(+) Am CDS//exon       - chr2:100011310-100011311(+) m6A CDS//exon       24981863 chr2:100011315-100011316(+) m6A CDS//exon       24981863 chr2:100011325-100011326(+) m6A CDS//exon       24981863 chr2:100011331-100011332(+) m6A CDS//exon       24981863 chr2:100013327-100013328(+) m6A CDS//exon       24981863 chr2:100013334-100013335(+) m6A CDS//exon       24981863 chr2:100013548-100013549(+) m6A exon//intron       24209618 chr2:100015278-100015279(+) m6A CDS//exon       27773535 chr2:100015302-100015303(+) m6A CDS//exon       27773535 chr2:100015338-100015339(+) m6A CDS//exon       27773535 chr2:100015800-100015801(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22608085 chr2:100015897-100015898(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:100015944-100015945(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:100015956-100015957(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:100015970-100015971(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:100015980-100015981(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:100016032-100016033(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:100016040-100016041(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:100017070-100017071(+) m6A 3'UTR       27773535//22608085 chr2:100017094-100017095(+) m6A 3'UTR       27773535//22608085 chr2:100017223-100017224(+) m6A 3'UTR       27773535 chr2:100017432-100017433(+) m6A 3'UTR       27773535 chr2:100017442-100017443(+) m6A 3'UTR       27773535 chr2:100017467-100017468(+) m6A 3'UTR       27773535 chr2:100017476-100017477(+) m6A 3'UTR       27773535 chr2:100017580-100017581(+) m6A 3'UTR       27773535 chr2:100017614-100017615(+) m6A 3'UTR       27773535 chr2:99953847-99953848(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:99953939-99953940(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:99953957-99953958(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:99953975-99953976(+) m6A 5'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr2:99954028-99954029(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:99954036-99954037(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:99954048-99954049(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr2:99976764-99976765(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:99976817-99976818(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:99976948-99976949(+) m6A CDS       24209618//24981863//27773535//22608085 chr2:99976997-99976998(+) m6A CDS       24209618//24981863//27773535//22608085 chr2:99977620-99977621(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:99977663-99977664(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr2:99977678-99977679(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr2:99977739-99977740(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:99977747-99977748(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:99977798-99977799(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:99977960-99977961(+) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr2:99977980-99977981(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr2:99978042-99978043(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr2:99978110-99978111(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr2:99978124-99978125(+) Am CDS       - chr2:99978144-99978145(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr2:99978167-99978168(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr2:99978196-99978197(+) m1A CDS       26863196 chr2:99978201-99978202(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr2:99978264-99978265(+) m6A CDS       24284625//25456834//24981863//27773535//22608085 chr2:99980122-99980123(+) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085 chr2:99980192-99980193(+) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085 chr2:99980251-99980252(+) m1A CDS       26863196 chr2:99980258-99980259(+) m6A CDS       24284625//25456834//24981863//27773535//22575960//22608085 chr2:99980744-99980745(+) m6A CDS       24284625//25456834//24981863//27773535//22575960//22608085 chr2:99980813-99980814(+) m6A CDS       25456834//24981863//27773535//22575960//22608085 chr2:99980867-99980868(+) m6A CDS       24981863//27773535//22608085 chr2:99984976-99984977(+) m6A CDS       24981863//27773535//22608085 chr2:99985897-99985898(+) m6A CDS       24981863//27773535//22575960//22608085 chr2:99985908-99985909(+) Cm CDS       - chr2:99985922-99985923(+) m6A CDS       24209618//24981863//27773535//22575960//22608085 chr2:99985939-99985940(+) m6A CDS       24209618//24981863//27773535//22575960//22608085 chr2:99988124-99988125(+) m1A CDS       26863196 chr2:99988183-99988184(+) m6A CDS       24209618//25456834//24981863//27773535//22575960//22608085 chr2:99992818-99992819(+) m6A CDS       24209618//25456834//24981863//27773535//22575960//22608085 chr2:99992845-99992846(+) m6A CDS       24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr2:99992872-99992873(+) m1A CDS       26863196 chr2:99992881-99992882(+) m1A CDS       26863196 chr2:99992902-99992903(+) m1A CDS       26863196 chr2:99992988-99992989(+) m6A CDS       24209618//25456834//24981863//27773535//22575960//22608085 chr2:99993054-99993055(+) m6A CDS       24209618//24981863//27773535//22575960//22608085 chr2:99995495-99995496(+) m6A CDS       24981863//27773535 chr2:99995512-99995513(+) m6A CDS       24981863//27773535 chr2:99995560-99995561(+) m6A CDS       24981863//27773535 chr2:99995571-99995572(+) m6A CDS       24981863//26404942 chr2:99995869-99995870(+) m6A CDS       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	EIF5B	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm HCC cell line (HepG2)|K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: EIF5B

Evidence Support:

Prediction-Evidence	miRanda//Targetscan
Support Database	VmiReg