Detail Information

Basic Information:


  VIRBase ID:  

VHID00280670

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:           GTF3C3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-2-5p GTF3C3
miRBase
Accession/Entrez ID		 MIMAT0000996 9330
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - TFIIIC102//TFiiiC2-102//TFIIICgamma

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GTF3C3
chr2:197656630(-) A-I      intronic
chr2:197659851(-) A-I      intronic
chr2:197656544(-) A-I      ncRNA
chr2:197657009(-) A-I      intronic
chr2:197656970(-) A-I      intronic
chr2:197656996(-) A-I      intronic
chr2:197656578(-) A-I      ncRNA
chr2:197656598(-) A-I      ncRNA
chr2:197656549(-) A-I      ncRNA
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GTF3C3
chr2:197643968(-) A-G intron -    22484847
chr2:197656549(-) A-G intron -    22484847
chr2:197656578(-) A-G intron -    22484847
chr2:197656598(-) A-G intron -    22484847
chr2:197656951(-) T-C intron -    22484847
chr2:197656970(-) A-G intron -    22484847
chr2:197657049(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GTF3C3
chr2:197628552-197628553(-) m6A 3'UTR       27773535
chr2:197628582-197628583(-) m6A 3'UTR       27773535
chr2:197628618-197628619(-) m6A 3'UTR       27773535
chr2:197628734-197628735(-) m6A 3'UTR       27773535
chr2:197628740-197628741(-) m6A 3'UTR       27773535
chr2:197628791-197628792(-) m6A 3'UTR       27773535
chr2:197628868-197628869(-) m6A 3'UTR       27773535
chr2:197628878-197628879(-) m6A 3'UTR       27773535
chr2:197653990-197653991(-) Y CDS//exon       26075521
chr2:197656163-197656164(-) m6A 3'UTR//CDS//exon       27773535
chr2:197657696-197657697(-) m6A 3'UTR//CDS       24981863//27773535//27371828
chr2:197657756-197657757(-) m6A 3'UTR//CDS       24981863//27773535//27371828
chr2:197657870-197657871(-) m6A 3'UTR//CDS       24981863//27773535//27371828
chr2:197662537-197662538(-) m6A 3'UTR//CDS       24981863//27773535//27371828
chr2:197664247-197664248(-) m6A CDS       27773535
chr2:197664314-197664315(-) m6A CDS       27773535
chr2:197664336-197664337(-) m6A 5'UTR//CDS       27773535
chr2:197664349-197664350(-) m6A 5'UTR//CDS       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-2-5p
Exosome B cell line (Raji)     21505438
GTF3C3
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: GTF3C3

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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