Basic Information:

  VIRBase ID:  

VHID00280564

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          GAS7:  NM_001130831     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	GAS7
miRBase Accession/Entrez ID	MIMAT0000996	8522
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GAS7	chr17:9832859(-) A-I      intronic chr17:9832860(-) A-I      intronic chr17:9832900(-) A-I      intronic chr17:9832903(-) A-I      intronic chr17:10066643(-) A-I      intronic chr17:10066661(-) A-I      intronic chr17:10069469(-) A-I      intronic chr17:10069519(-) A-I      intronic chr17:9832888(-) A-I      intronic chr17:9817688(-) A-I      3'UTR chr17:10069520(-) A-I      intronic chr17:9817711(-) A-I      3'UTR chr17:10069536(-) A-I      intronic chr17:9832999(-) A-I      intronic chr17:9833015(-) A-I      intronic chr17:9836331(-) A-I      intronic chr17:9836437(-) A-I      intronic chr17:9836483(-) A-I      intronic chr17:9841661(-) A-I      intronic chr17:9841685(-) A-I      intronic chr17:9843097(-) A-I      intronic chr17:9843115(-) A-I      intronic chr17:9843120(-) A-I      intronic chr17:9849113(-) A-I      intronic chr17:9850978(-) A-I      intronic chr17:9850998(-) A-I      intronic chr17:9910819(-) A-I      intronic chr17:9853264(-) A-I      intronic chr17:9853356(-) A-I      intronic chr17:9853376(-) A-I      intronic chr17:9853448(-) A-I      intronic chr17:9853746(-) A-I      intronic chr17:9853777(-) A-I      intronic chr17:9853782(-) A-I      intronic chr17:9982249(-) A-I      intronic chr17:9853791(-) A-I      intronic chr17:9855072(-) A-I      intronic chr17:9981616(-) A-I      intronic chr17:9972067(-) A-I      intronic chr17:9873827(-) A-I      intronic chr17:9873866(-) A-I      intronic chr17:9873867(-) A-I      intronic chr17:9873897(-) A-I      intronic chr17:9878514(-) A-I      intronic chr17:9881995(-) A-I      intronic chr17:9884546(-) A-I      intronic chr17:9900021(-) A-I      intronic chr17:9900023(-) A-I      intronic chr17:9909684(-) A-I      intronic chr17:9909785(-) A-I      intronic chr17:9909880(-) A-I      intronic chr17:9909883(-) A-I      intronic chr17:9910776(-) A-I      intronic chr17:9910817(-) A-I      intronic chr17:9969560(-) A-I      intronic chr17:9913638(-) A-I      intronic chr17:9915876(-) A-I      intronic chr17:10041144(-) A-I      intronic chr17:9916176(-) A-I      intronic chr17:9916262(-) A-I      intronic chr17:9916308(-) A-I      intronic chr17:9919578(-) A-I      intronic chr17:9919580(-) A-I      intronic chr17:9919700(-) A-I      intronic chr17:9920365(-) A-I      intronic chr17:9920774(-) A-I      intronic chr17:9920919(-) A-I      intronic chr17:9951453(-) A-I      intronic chr17:9951471(-) A-I      intronic chr17:9953014(-) A-I      intronic chr17:9953043(-) A-I      intronic chr17:9953059(-) A-I      intronic chr17:9953066(-) A-I      intronic chr17:9953086(-) A-I      intronic chr17:9953106(-) A-I      intronic chr17:10041348(-) A-I      intronic chr17:10070507(-) A-I      intronic chr17:10070512(-) A-I      intronic chr17:10070513(-) A-I      intronic chr17:10071081(-) A-I      intronic chr17:10071187(-) A-I      intronic chr17:10077751(-) A-I      intronic chr17:10085681(-) A-I      intronic chr17:10085696(-) A-I      intronic chr17:10085704(-) A-I      intronic chr17:9953142(-) A-I      intronic chr17:9953188(-) A-I      intronic chr17:9953204(-) A-I      intronic chr17:9959944(-) A-I      intronic chr17:9960021(-) A-I      intronic chr17:9909795(-) A-I      intronic chr17:10013880(-) A-I      intronic chr17:10013888(-) A-I      intronic chr17:10070467(-) A-I      intronic chr17:10085741(-) A-I      intronic chr17:10085758(-) A-I      intronic chr17:10089433(-) A-I      intronic chr17:10092180(-) A-I      intronic chr17:10046375(-) A-I      intronic chr17:10052623(-) A-I      intronic chr17:10052670(-) A-I      intronic chr17:10070447(-) A-I      intronic chr17:10066645(-) A-I      intronic chr17:10066646(-) A-I      intronic chr17:10066667(-) A-I      intronic chr17:9996803(-) A-I      intronic chr17:9998057(-) A-I      intronic chr17:9998064(-) A-I      intronic chr17:9996707(-) A-I      intronic chr17:9996704(-) A-I      intronic chr17:9996699(-) A-I      intronic chr17:9996684(-) A-I      intronic chr17:9824647(-) A-I      intronic chr17:9824653(-) A-I      intronic chr17:10013927(-) A-I      intronic chr17:10032757(-) A-I      intronic chr17:10036719(-) A-I      intronic chr17:10069375(-) A-I      intronic chr17:10069387(-) A-I      intronic chr17:10069438(-) A-I      intronic chr17:10069462(-) A-I      intronic chr17:10069473(-) A-I      intronic chr17:10069497(-) A-I      intronic chr17:10069505(-) A-I      intronic chr17:10069544(-) A-I      intronic chr17:10069545(-) A-I      intronic chr17:10069554(-) A-I      intronic chr17:10069568(-) A-I      intronic chr17:10040319(-) A-I      intronic chr17:9825087(-) A-I      intronic chr17:9825213(-) A-I      intronic chr17:9832907(-) A-I      intronic chr17:9832929(-) A-I      intronic chr17:9832997(-) A-I      intronic chr17:9817724(-) A-I      3'UTR chr17:9843065(-) A-I      intronic chr17:10058469(-) A-I      intronic chr17:10023990(-) A-I      intronic chr17:10078311(-) A-I      intronic chr17:10065236(-) A-I      intronic chr17:9941614(-) A-I      intronic chr17:9996774(-) A-I      intronic chr17:9853384(-) A-I      intronic chr17:9941566(-) A-I      intronic chr17:10047985(-) A-I      intronic chr17:9826363(-) A-I      intronic chr17:9878564(-) A-I      intronic chr17:10089813(-) A-I      intronic chr17:9824473(-) A-I      intronic chr17:9920236(-) A-I      intronic chr17:10078327(-) A-I      intronic chr17:10047992(-) A-I      intronic chr17:10085614(-) A-I      intronic chr17:9981587(-) A-I      intronic chr17:10069573(-) A-I      intronic chr17:9836887(-) A-I      intronic chr17:10064064(-) A-I      intronic chr17:10078307(-) A-I      intronic chr17:9959565(-) A-I      intronic chr17:9830682(-) A-I      intronic chr17:10070982(-) A-I      intronic chr17:10036577(-) A-I      intronic chr17:9824582(-) A-I      intronic chr17:9873690(-) A-I      intronic chr17:10040286(-) A-I      intronic chr17:10057925(-) A-I      intronic chr17:9824602(-) A-I      intronic chr17:9843055(-) A-I      intronic chr17:9993302(-) A-I      intronic chr17:9953209(-) A-I      intronic chr17:9838190(-) A-I      intronic chr17:10066490(-) A-I      intronic chr17:9836914(-) A-I      intronic chr17:9827553(-) A-I      intronic chr17:9838095(-) A-I      intronic chr17:10057699(-) A-I      intronic chr17:10093737(-) A-I      intronic chr17:9824707(-) A-I      intronic chr17:9908170(-) A-I      intronic chr17:9941661(-) A-I      intronic chr17:9830680(-) A-I      intronic chr17:9878550(-) A-I      intronic chr17:9853581(-) A-I      intronic chr17:10066594(-) A-I      intronic chr17:10066689(-) A-I      intronic chr17:10069612(-) A-I      intronic chr17:9853652(-) A-I      intronic chr17:10036580(-) A-I      intronic chr17:9999005(-) A-I      intronic chr17:9853318(-) A-I      intronic chr17:10066608(-) A-I      intronic chr17:9837155(-) A-I      intronic chr17:10090196(-) A-I      intronic chr17:9824706(-) A-I      intronic chr17:9959555(-) A-I      intronic chr17:10066604(-) A-I      intronic chr17:10089400(-) A-I      intronic chr17:9835626(-) A-I      intronic chr17:10063441(-) A-I      intronic chr17:9833073(-) A-I      intronic chr17:9817746(-) A-I      3'UTR chr17:9853244(-) A-I      intronic chr17:10036078(-) A-I      intronic chr17:10051848(-) A-I      intronic chr17:9817675(-) A-I      3'UTR chr17:9999068(-) A-I      intronic chr17:9843105(-) A-I      intronic chr17:9982259(-) A-I      intronic chr17:9817721(-) A-I      3'UTR chr17:10078436(-) A-I      intronic chr17:10066531(-) A-I      intronic chr17:10063227(-) A-I      intronic chr17:9919455(-) A-I      intronic chr17:10066688(-) A-I      intronic chr17:9931680(-) A-I      intronic chr17:10052518(-) A-I      intronic chr17:9817649(-) A-I      3'UTR chr17:9850939(-) A-I      intronic chr17:9836389(-) A-I      intronic chr17:9853798(-) A-I      intronic chr17:10066513(-) A-I      intronic chr17:10040379(-) A-I      intronic chr17:9841782(-) A-I      intronic chr17:10092024(-) A-I      intronic chr17:9817708(-) A-I      3'UTR chr17:9999013(-) A-I      intronic chr17:9838248(-) A-I      intronic chr17:9824667(-) A-I      intronic chr17:9824651(-) A-I      intronic chr17:10069583(-) A-I      intronic chr17:10071288(-) A-I      intronic chr17:9824638(-) A-I      intronic chr17:10063170(-) A-I      intronic chr17:10078323(-) A-I      intronic chr17:10036028(-) A-I      intronic chr17:10091411(-) A-I      intronic chr17:10082390(-) A-I      intronic chr17:9886651(-) A-I      intronic chr17:9853341(-) A-I      intronic chr17:9915847(-) A-I      intronic chr17:10092080(-) A-I      intronic chr17:10065214(-) A-I      intronic chr17:9919446(-) A-I      intronic chr17:10071198(-) A-I      intronic chr17:10063495(-) A-I      intronic chr17:10086900(-) A-I      intronic chr17:9959690(-) A-I      intronic chr17:9817738(-) A-I      3'UTR chr17:10057613(-) A-I      intronic chr17:10034817(-) A-I      intronic chr17:9836322(-) A-I      intronic chr17:9835694(-) A-I      intronic chr17:9817777(-) A-I      3'UTR chr17:9876770(-) A-I      intronic chr17:10057814(-) A-I      intronic chr17:10092236(-) A-I      intronic chr17:9960024(-) A-I      intronic chr17:10036069(-) A-I      intronic chr17:10065337(-) A-I      intronic chr17:9843197(-) A-I      intronic chr17:9908083(-) A-I      intronic chr17:9824644(-) A-I      intronic chr17:9817611(-) A-I      3'UTR chr17:10084577(-) A-I      intronic chr17:9817816(-) A-I      3'UTR chr17:10065136(-) A-I      intronic chr17:9853707(-) A-I      intronic chr17:10066709(-) A-I      intronic chr17:9817612(-) A-I      3'UTR chr17:10071235(-) A-I      intronic chr17:9920913(-) A-I      intronic chr17:10069518(-) A-I      intronic chr17:10094669(-) A-I      intronic chr17:10044601(-) A-I      intronic chr17:9835728(-) A-I      intronic chr17:9841565(-) A-I      intronic chr17:10046416(-) A-I      intronic chr17:10058470(-) A-I      intronic chr17:10038427(-) A-I      intronic chr17:9817748(-) A-I      3'UTR chr17:9835597(-) A-I      intronic chr17:9851022(-) A-I      intronic chr17:9982456(-) A-I      intronic chr17:10061781(-) A-I      intronic chr17:10014056(-) A-I      intronic chr17:9900230(-) A-I      intronic chr17:9913639(-) A-I      intronic chr17:10092094(-) A-I      intronic chr17:9853319(-) A-I      intronic chr17:10069432(-) A-I      intronic chr17:10069344(-) A-I      intronic chr17:9827761(-) A-I      intronic chr17:9874787(-) A-I      intronic chr17:10066715(-) A-I      intronic chr17:9916295(-) A-I      intronic chr17:9835574(-) A-I      intronic chr17:10045941(-) A-I      intronic chr17:9950049(-) A-I      intronic chr17:10063241(-) A-I      intronic chr17:10078429(-) A-I      intronic chr17:10069540(-) A-I      intronic chr17:10069479(-) A-I      intronic chr17:10043568(-) A-I      intronic chr17:9920364(-) A-I      intronic chr17:10065192(-) A-I      intronic chr17:9878506(-) A-I      intronic chr17:10089560(-) A-I      intronic chr17:9910891(-) A-I      intronic chr17:10013879(-) A-I      intronic chr17:9951422(-) A-I      intronic chr17:9973856(-) A-I      intronic chr17:10078268(-) A-I      intronic chr17:10069437(-) A-I      intronic chr17:10070640(-) A-I      intronic chr17:9830765(-) A-I      intronic chr17:9909851(-) A-I      intronic chr17:10063188(-) A-I      intronic chr17:10078996(-) A-I      intronic chr17:9824656(-) A-I      intronic chr17:9982461(-) A-I      intronic chr17:9951633(-) A-I      intronic chr17:9997914(-) A-I      intronic chr17:9853580(-) A-I      intronic chr17:9998904(-) A-I      intronic chr17:9831558(-) A-I      intronic chr17:9830509(-) A-I      intronic chr17:10065297(-) A-I      intronic chr17:9830692(-) A-I      intronic chr17:10063235(-) A-I      intronic chr17:9915883(-) A-I      intronic chr17:9855976(-) A-I      intronic chr17:10047950(-) A-I      intronic chr17:9835608(-) A-I      intronic chr17:9827693(-) A-I      intronic chr17:10071289(-) A-I      intronic chr17:9971828(-) A-I      intronic chr17:9920849(-) A-I      intronic chr17:9825032(-) A-I      intronic chr17:9853761(-) A-I      intronic chr17:9855977(-) A-I      intronic chr17:10058447(-) A-I      intronic chr17:9920910(-) A-I      intronic chr17:9994735(-) A-I      intronic chr17:10094370(-) A-I      intronic chr17:9914917(-) A-I      intronic chr17:9843204(-) A-I      intronic chr17:10032680(-) A-I      intronic chr17:9830775(-) A-I      intronic chr17:9914814(-) A-I      intronic chr17:9942998(-) A-I      intronic chr17:9841641(-) A-I      intronic chr17:10041444(-) A-I      intronic chr17:9855411(-) A-I      intronic chr17:10040309(-) A-I      intronic chr17:9915860(-) A-I      intronic chr17:9915193(-) A-I      intronic chr17:10055000(-) A-I      intronic chr17:9836239(-) A-I      intronic chr17:10065587(-) A-I      intronic chr17:10063263(-) A-I      intronic chr17:10040283(-) A-I      intronic chr17:10076896(-) A-I      intronic chr17:10066655(-) A-I      intronic chr17:9843126(-) A-I      intronic chr17:10061707(-) A-I      intronic chr17:9830720(-) A-I      intronic chr17:9838217(-) A-I      intronic chr17:9914488(-) A-I      intronic chr17:10017370(-) A-I      intronic chr17:9878484(-) A-I      intronic chr17:9915707(-) A-I      intronic chr17:9834639(-) A-I      intronic chr17:10069508(-) A-I      intronic chr17:10078362(-) A-I      intronic chr17:10065338(-) A-I      intronic chr17:9855983(-) A-I      intronic chr17:9920784(-) A-I      intronic chr17:9942155(-) A-I      intronic chr17:9953076(-) A-I      intronic chr17:10063314(-) A-I      intronic chr17:10067966(-) A-I      intronic chr17:9843106(-) A-I      intronic chr17:10034768(-) A-I      intronic chr17:9853924(-) A-I      intronic chr17:10079103(-) A-I      intronic chr17:9854998(-) A-I      intronic chr17:9826341(-) A-I      intronic chr17:10066105(-) A-I      intronic chr17:10066670(-) A-I      intronic chr17:9984706(-) A-I      intronic chr17:9878665(-) A-I      intronic chr17:9915743(-) A-I      intronic chr17:10035977(-) A-I      intronic chr17:9853360(-) A-I      intronic chr17:10063200(-) A-I      intronic chr17:9953171(-) A-I      intronic chr17:10046465(-) A-I      intronic chr17:9817815(-) A-I      3'UTR chr17:9817682(-) A-I      3'UTR chr17:9817615(-) A-I      3'UTR chr17:9817574(-) A-I      3'UTR chr17:9817641(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GAS7	chr17:10063170(-) A-I intron -    15342557 chr17:10063188(-) A-I intron -    15342557 chr17:10063200(-) A-I intron -    15342557 chr17:10063227(-) A-I intron -    15342557 chr17:10063235(-) A-I intron -    15342557 chr17:10063241(-) A-I intron -    15342557 chr17:10063263(-) A-I intron -    15342557 chr17:10063314(-) A-I intron -    15342557 chr17:10063495(-) A-I intron -    15342557 chr17:10064064(-) A-I intron -    15342557 chr17:10065136(-) A-I intron -    15342557 chr17:10065192(-) A-I intron -    15342557 chr17:10065214(-) A-I intron -    15342557 chr17:10065236(-) A-I intron -    15342557 chr17:10065297(-) A-I intron -    15342557 chr17:10065337(-) A-I intron -    15342557 chr17:10065338(-) A-I intron -    15342557 chr17:10065587(-) A-I intron -    15342557 chr17:10066105(-) A-I intron -    15342557 chr17:10066490(-) A-I intron -    15342557 chr17:10066513(-) A-I intron -    15342557 chr17:10066531(-) A-I intron -    15342557 chr17:10066594(-) A-I intron -    15342557 chr17:10066608(-) A-I intron -    15342557 chr17:10066670(-) A-I intron -    15342557 chr17:10066688(-) A-I intron -    15342557 chr17:10066689(-) A-I intron -    15342557 chr17:10066709(-) A-I intron -    15342557 chr17:10066715(-) A-I intron -    15342557 chr17:9817612(-) A-G exon 3'UTR    22484847 chr17:9817615(-) A-G exon 3'UTR    22484847 chr17:9817746(-) A-G exon 3'UTR    22484847 chr17:9817747(-) C-T exon 3'UTR    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GAS7	chr17:10101848-10101849(-) m6A 5'UTR       27371828 chr17:9820264-9820265(-) m6A 3'UTR       27371828 chr17:9820280-9820281(-) m6A 3'UTR       27371828 chr17:9820316-9820317(-) m6A 3'UTR//CDS       25456834//27371828 chr17:9820354-9820355(-) m6A 3'UTR//intron       25456834//27371828 chr17:9820396-9820397(-) m6A 3'UTR//intron       25456834//27371828 chr17:9820557-9820558(-) m6A CDS//exon//intron       25456834//27371828 chr17:9820608-9820609(-) m6A CDS//exon//intron       25456834//27371828 chr17:9820620-9820621(-) m6A CDS//exon//intron       25456834//27371828 chr17:9821337-9821338(-) m6A CDS//exon//intron       25456834//27371828 chr17:9828039-9828040(-) m6A exon//intron       27371828 chr17:9828827-9828828(-) m6A CDS//exon//intron       27371828 chr17:9828837-9828838(-) m6A CDS//exon//intron       27371828 chr17:9828870-9828871(-) m6A CDS//exon//intron       27371828 chr17:9828884-9828885(-) m6A CDS//exon//intron       27371828 chr17:9830030-9830031(-) m6A CDS//exon//intron       27371828 chr17:9830042-9830043(-) m6A CDS//exon//intron       27371828 chr17:9850258-9850259(-) m6A CDS//exon//intron       - chr17:9850271-9850272(-) m6A CDS//exon//intron       - chr17:9850295-9850296(-) m6A CDS//exon//intron       - chr17:9862302-9862303(-) m6A exon//intron       - chr17:9862528-9862529(-) m6A CDS//exon//intron       - chr17:9862570-9862571(-) m6A CDS//exon//intron       - chr17:9862606-9862607(-) m6A CDS//intron       - chr17:9862641-9862642(-) m6A 5'UTR//intron       - chr17:9873034-9873035(-) m6A CDS//intron       - chr17:9873055-9873056(-) m6A CDS//intron       - chr17:9885198-9885199(-) m6A CDS//exon//intron       - chr17:9939913-9939914(-) m6A 5'UTR//exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	GAS7	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: GAS7

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).