Basic Information:

  VIRBase ID:  

VHID00280353

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          SON:  NR_103797     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	SON
miRBase Accession/Entrez ID	MIMAT0000996	6651
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BASS1//C21orf50//DBP-5//NREBP//SON3//TOKIMS

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SON	chr21:34945887(+) A-I      intronic chr21:34919028(+) A-I      intronic chr21:34919468(+) A-I      intronic chr21:34919417(+) A-I      intronic chr21:34919406(+) A-I      intronic chr21:34919380(+) A-I      intronic chr21:34918966(+) A-I      intronic chr21:34918940(+) A-I      intronic chr21:34918931(+) A-I      intronic chr21:34918910(+) A-I      intronic chr21:34918831(+) A-I      intronic chr21:34918830(+) A-I      intronic chr21:34918916(+) A-I      intronic chr21:34920236(+) A-I      intronic chr21:34919562(+) A-I      intronic chr21:34921520(+) A-I      intronic chr21:34919012(+) A-I      intronic chr21:34919381(+) A-I      intronic chr21:34919471(+) A-I      intronic chr21:34919420(+) A-I      intronic chr21:34919311(+) A-I      intronic chr21:34918972(+) A-I      intronic chr21:34919410(+) A-I      intronic chr21:34918967(+) A-I      intronic chr21:34918976(+) A-I      intronic chr21:34918815(+) A-I      intronic chr21:34920289(+) A-I      intronic chr21:34920303(+) A-I      intronic chr21:34918909(+) A-I      intronic chr21:34919407(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SON	chr21:34923319(+) A-I exon CDS    22327324 chr21:34923934(+) A-I exon CDS    22327324 chr21:34929693(+) A-I intron -    21960545 chr21:34918967(+) A-G intron -    22484847 chr21:34918972(+) A-G intron -    22484847 chr21:34919550(+) A-G intron -    22484847 chr21:34919562(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SON	chr21:34915071-34915072(+) m6A 5'UTR       24284625//24981863 chr21:34915083-34915084(+) m6A 5'UTR       24284625//24981863 chr21:34915100-34915101(+) m6A 5'UTR       24284625//24981863 chr21:34915148-34915149(+) m6A 5'UTR       24284625 chr21:34915163-34915164(+) m6A 5'UTR       24284625 chr21:34915215-34915216(+) m6A 5'UTR       24284625 chr21:34915272-34915273(+) m6A 5'UTR       24284625 chr21:34915311-34915312(+) m6A 5'UTR       24284625//25456834//24981863 chr21:34915361-34915362(+) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr21:34918549-34918550(+) m6A CDS//exon       24284625//24209618//24981863//27773535 chr21:34918571-34918572(+) m6A CDS//exon       24284625//24981863//27773535 chr21:34918668-34918669(+) m6A CDS//exon       24284625//24981863//27773535//22575960 chr21:34918797-34918798(+) m6A exon//intron       24981863//27773535//22608085 chr21:34921825-34921826(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr21:34921883-34921884(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34921929-34921930(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34921976-34921977(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34922019-34922020(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34922071-34922072(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34922100-34922101(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34922146-34922147(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34922167-34922168(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34922175-34922176(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34922241-34922242(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34922364-34922365(+) Gm CDS//intron       - chr21:34922449-34922450(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr21:34922470-34922471(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr21:34922607-34922608(+) m6A CDS//intron       24284625//24981863//26404942//22608085 chr21:34922635-34922636(+) m6A CDS//intron       24284625//24981863//26404942//22608085 chr21:34923051-34923052(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34923105-34923106(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34923186-34923187(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34923631-34923632(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34923703-34923704(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34923731-34923732(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34923761-34923762(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34923791-34923792(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34923821-34923822(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34923851-34923852(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34923881-34923882(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34923911-34923912(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34923941-34923942(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr21:34923971-34923972(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr21:34924001-34924002(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr21:34924031-34924032(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34924091-34924092(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34924151-34924152(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr21:34924371-34924372(+) m6A CDS//intron       24284625//26404942 chr21:34924376-34924377(+) m6A CDS//intron       24284625//26404942 chr21:34924407-34924408(+) m6A CDS//intron       24284625//26404942 chr21:34924440-34924441(+) m6A CDS//intron       24284625//24981863//26404942 chr21:34924503-34924504(+) m6A CDS//intron       24284625//24981863//22608085 chr21:34925061-34925062(+) m6A CDS//intron       24284625//26404942//22575960//22608085 chr21:34925286-34925287(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34925352-34925353(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34925373-34925374(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34925398-34925399(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34925418-34925419(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34925458-34925459(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr21:34925467-34925468(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr21:34925493-34925494(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr21:34925738-34925739(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr21:34925799-34925800(+) m6A CDS//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr21:34925841-34925842(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34925908-34925909(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34926072-34926073(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34926087-34926088(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34926117-34926118(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34926134-34926135(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34926174-34926175(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34926250-34926251(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr21:34926255-34926256(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr21:34926310-34926311(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr21:34926342-34926343(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr21:34926358-34926359(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22575960//22608085 chr21:34926450-34926451(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22575960//22608085 chr21:34926579-34926580(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34926607-34926608(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34926679-34926680(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34926741-34926742(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34926758-34926759(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34926798-34926799(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr21:34926929-34926930(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34926959-34926960(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr21:34926992-34926993(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr21:34927035-34927036(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr21:34927117-34927118(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr21:34927285-34927286(+) m6A CDS//intron       24209618//25456834//24981863//26404942//22608085 chr21:34927306-34927307(+) m6A CDS//intron       24209618//25456834//24981863//26404942//22608085 chr21:34927374-34927375(+) m1A CDS//intron       26863196//26863410 chr21:34927614-34927615(+) m1A CDS//intron       26863410 chr21:34927668-34927669(+) Cm CDS//intron       - chr21:34929530-34929531(+) Y CDS       26075521 chr21:34929612-34929613(+) m6A CDS       - chr21:34929864-34929865(+) m6A 3'UTR//intron       24209618//24981863//22575960//22608085 chr21:34929999-34930000(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34930005-34930006(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr21:34930079-34930080(+) m6A 3'UTR//intron       24284625//24209618//24981863//26404942//22608085 chr21:34930198-34930199(+) m6A 3'UTR//intron       24209618//24981863//22608085 chr21:34930807-34930808(+) Y 3'UTR//intron       26075521 chr21:34930847-34930848(+) m6A 3'UTR//intron       24981863 chr21:34930909-34930910(+) m6A 3'UTR//intron       24981863//22608085 chr21:34931543-34931544(+) m6A CDS       24981863 chr21:34931588-34931589(+) m6A CDS       24981863 chr21:34931618-34931619(+) m6A CDS       24981863 chr21:34931645-34931646(+) m6A CDS       24981863 chr21:34931654-34931655(+) m6A CDS       24981863 chr21:34931660-34931661(+) m6A CDS       24981863 chr21:34941353-34941354(+) m6A CDS//exon       24981863//27773535 chr21:34941425-34941426(+) m6A exon//intron       24981863//27773535 chr21:34941449-34941450(+) m6A exon//intron       24981863//27773535 chr21:34941462-34941463(+) m6A exon//intron       24981863//27773535 chr21:34941475-34941476(+) m6A exon//intron       24981863 chr21:34941534-34941535(+) m6A exon//intron       24981863 chr21:34941547-34941548(+) m6A exon//intron       24981863 chr21:34942032-34942033(+) m6A 3'UTR//intron       - chr21:34942107-34942108(+) m6A 3'UTR//exon//intron       - chr21:34945586-34945587(+) m6A exon//intron       24981863 chr21:34945707-34945708(+) m6A 3'UTR//CDS//exon       24981863 chr21:34945726-34945727(+) m6A 3'UTR//CDS//exon       24981863 chr21:34945748-34945749(+) m6A 3'UTR//CDS//exon       24981863 chr21:34948835-34948836(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr21:34949737-34949738(+) m6A 3'UTR//exon       27773535 chr21:34949771-34949772(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	SON	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: SON

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).