Basic Information:

  VIRBase ID:  

VHID00280299

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          SCP2:  NM_001193600     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	SCP2
miRBase Accession/Entrez ID	MIMAT0000996	6342
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	NLTP//NSL-TP//SCOX//SCP-2//SCP-CHI//SCP-X//SCPX

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SCP2	chr1:53427726(+) A-I      intronic chr1:53479105(+) A-I      intronic chr1:53496314(+) A-I      intronic chr1:53492351(+) A-I      intronic chr1:53427703(+) A-I      intronic chr1:53492367(+) A-I      intronic chr1:53496292(+) A-I      intronic chr1:53479109(+) A-I      intronic chr1:53492322(+) A-I      intronic chr1:53492319(+) A-I      intronic chr1:53479120(+) A-I      intronic chr1:53492361(+) A-I      intronic chr1:53479110(+) A-I      intronic chr1:53479117(+) A-I      intronic chr1:53492318(+) A-I      intronic chr1:53496309(+) A-I      intronic chr1:53504264(+) A-I      intronic chr1:53504163(+) A-I      intronic chr1:53504162(+) A-I      intronic chr1:53503480(+) A-I      intronic chr1:53502734(+) A-I      intronic chr1:53496325(+) A-I      intronic chr1:53496320(+) A-I      intronic chr1:53495700(+) A-I      intronic chr1:53495661(+) A-I      intronic chr1:53495660(+) A-I      intronic chr1:53495063(+) A-I      intronic chr1:53495036(+) A-I      intronic chr1:53494967(+) A-I      intronic chr1:53492440(+) A-I      intronic chr1:53492419(+) A-I      intronic chr1:53492330(+) A-I      intronic chr1:53492298(+) A-I      intronic chr1:53492230(+) A-I      intronic chr1:53484204(+) A-I      intronic chr1:53483796(+) A-I      intronic chr1:53483736(+) A-I      intronic chr1:53483724(+) A-I      intronic chr1:53483710(+) A-I      intronic chr1:53478862(+) A-I      intronic chr1:53469309(+) A-I      intronic chr1:53469114(+) A-I      intronic chr1:53467623(+) A-I      intronic chr1:53466568(+) A-I      intronic chr1:53466547(+) A-I      intronic chr1:53466453(+) A-I      intronic chr1:53465828(+) A-I      intronic chr1:53464062(+) A-I      intronic chr1:53456223(+) A-I      intronic chr1:53443383(+) A-I      intronic chr1:53443364(+) A-I      intronic chr1:53441050(+) A-I      intronic chr1:53441042(+) A-I      intronic chr1:53441036(+) A-I      intronic chr1:53435035(+) A-I      intronic chr1:53433788(+) A-I      intronic chr1:53431424(+) A-I      intronic chr1:53431406(+) A-I      intronic chr1:53430612(+) A-I      intronic chr1:53430607(+) A-I      intronic chr1:53430520(+) A-I      intronic chr1:53430483(+) A-I      intronic chr1:53430079(+) A-I      intronic chr1:53427826(+) A-I      intronic chr1:53427723(+) A-I      intronic chr1:53417572(+) A-I      intronic chr1:53411730(+) A-I      intronic chr1:53417530(+) A-I      intronic chr1:53427673(+) A-I      intronic chr1:53394295(+) A-I      intronic chr1:53395197(+) A-I      intronic chr1:53395258(+) A-I      intronic chr1:53395555(+) A-I      intronic chr1:53405578(+) A-I      intronic chr1:53411145(+) A-I      intronic chr1:53411659(+) A-I      intronic chr1:53419773(+) A-I      intronic chr1:53504101(+) A-I      intronic chr1:53427606(+) A-I      intronic chr1:53427653(+) A-I      intronic chr1:53430552(+) A-I      intronic chr1:53412871(+) A-I      intronic chr1:53499861(+) A-I      intronic chr1:53433752(+) A-I      intronic chr1:53502663(+) A-I      intronic chr1:53484302(+) A-I      intronic chr1:53416833(+) A-I      intronic chr1:53484249(+) A-I      intronic chr1:53483590(+) A-I      intronic chr1:53462889(+) A-I      intronic chr1:53430124(+) A-I      intronic chr1:53503721(+) A-I      intronic chr1:53492400(+) A-I      intronic chr1:53466467(+) A-I      intronic chr1:53506984(+) A-I      intronic chr1:53395436(+) A-I      intronic chr1:53416747(+) A-I      intronic chr1:53405525(+) A-I      intronic chr1:53457238(+) A-I      intronic chr1:53412821(+) A-I      intronic chr1:53395218(+) A-I      intronic chr1:53504226(+) A-I      intronic chr1:53404963(+) A-I      intronic chr1:53411921(+) A-I      intronic chr1:53484392(+) A-I      intronic chr1:53484345(+) A-I      intronic chr1:53395346(+) A-I      intronic chr1:53503484(+) A-I      intronic chr1:53415874(+) A-I      intronic chr1:53396055(+) A-I      intronic chr1:53405934(+) A-I      intronic chr1:53394404(+) A-I      intronic chr1:53456246(+) A-I      intronic chr1:53456200(+) A-I      intronic chr1:53503685(+) A-I      intronic chr1:53400751(+) A-I      intronic chr1:53433742(+) A-I      intronic chr1:53492704(+) A-I      intronic chr1:53417515(+) A-I      intronic chr1:53394288(+) A-I      intronic chr1:53434974(+) A-I      intronic chr1:53484158(+) A-I      intronic chr1:53394956(+) A-I      intronic chr1:53484324(+) A-I      intronic chr1:53504339(+) A-I      intronic chr1:53427795(+) A-I      intronic chr1:53450392(+) A-I      intronic chr1:53483607(+) A-I      intronic chr1:53492225(+) A-I      intronic chr1:53407254(+) A-I      intronic chr1:53395375(+) A-I      intronic chr1:53503673(+) A-I      intronic chr1:53405371(+) A-I      intronic chr1:53394921(+) A-I      intronic chr1:53427686(+) A-I      intronic chr1:53509830(+) A-I      intronic chr1:53479188(+) A-I      intronic chr1:53484325(+) A-I      intronic chr1:53427739(+) A-I      intronic chr1:53396213(+) A-I      intronic chr1:53504216(+) A-I      intronic chr1:53395012(+) A-I      intronic chr1:53412838(+) A-I      intronic chr1:53502665(+) A-I      intronic chr1:53430575(+) A-I      intronic chr1:53439463(+) A-I      intronic chr1:53394277(+) A-I      intronic chr1:53443547(+) A-I      intronic chr1:53400775(+) A-I      intronic chr1:53499828(+) A-I      intronic chr1:53412001(+) A-I      intronic chr1:53433887(+) A-I      intronic chr1:53469463(+) A-I      intronic chr1:53447304(+) A-I      intronic chr1:53395480(+) A-I      intronic chr1:53427614(+) A-I      intronic chr1:53494709(+) A-I      intronic chr1:53395460(+) A-I      intronic chr1:53432626(+) A-I      intronic chr1:53405522(+) A-I      intronic chr1:53427674(+) A-I      intronic chr1:53506963(+) A-I      intronic chr1:53395502(+) A-I      intronic chr1:53492405(+) A-I      intronic chr1:53466506(+) A-I      intronic chr1:53395556(+) A-I      intronic chr1:53481662(+) A-I      intronic chr1:53483407(+) A-I      intronic chr1:53430508(+) A-I      intronic chr1:53394319(+) A-I      intronic chr1:53396175(+) A-I      intronic chr1:53405036(+) A-I      intronic chr1:53394986(+) A-I      intronic chr1:53416738(+) A-I      intronic chr1:53427715(+) A-I      intronic chr1:53419760(+) A-I      intronic chr1:53395198(+) A-I      intronic chr1:53395477(+) A-I      intronic chr1:53483656(+) A-I      intronic chr1:53469473(+) A-I      intronic chr1:53430057(+) A-I      intronic chr1:53495763(+) A-I      intronic chr1:53504267(+) A-I      intronic chr1:53450389(+) A-I      intronic chr1:53447165(+) A-I      intronic chr1:53502632(+) A-I      intronic chr1:53404946(+) A-I      intronic chr1:53492335(+) A-I      intronic chr1:53494716(+) A-I      intronic chr1:53394291(+) A-I      intronic chr1:53495821(+) A-I      intronic chr1:53506821(+) A-I      intronic chr1:53435030(+) A-I      intronic chr1:53479317(+) A-I      intronic chr1:53424659(+) A-I      intronic chr1:53395494(+) A-I      intronic chr1:53395217(+) A-I      intronic chr1:53419538(+) A-I      intronic chr1:53433747(+) A-I      intronic chr1:53396177(+) A-I      intronic chr1:53465812(+) A-I      intronic chr1:53429991(+) A-I      intronic chr1:53396218(+) A-I      intronic chr1:53479217(+) A-I      intronic chr1:53492359(+) A-I      intronic chr1:53440872(+) A-I      intronic chr1:53427713(+) A-I      intronic chr1:53395141(+) A-I      intronic chr1:53419782(+) A-I      intronic chr1:53426595(+) A-I      intronic chr1:53434998(+) A-I      intronic chr1:53483566(+) A-I      intronic chr1:53427691(+) A-I      intronic chr1:53469064(+) A-I      intronic chr1:53416863(+) A-I      intronic chr1:53456247(+) A-I      intronic chr1:53506820(+) A-I      intronic chr1:53503695(+) A-I      intronic chr1:53484306(+) A-I      intronic chr1:53395246(+) A-I      intronic chr1:53412648(+) A-I      intronic chr1:53429909(+) A-I      intronic chr1:53430133(+) A-I      intronic chr1:53439474(+) A-I      intronic chr1:53484218(+) A-I      intronic chr1:53484368(+) A-I      intronic chr1:53483652(+) A-I      intronic chr1:53432773(+) A-I      intronic chr1:53396028(+) A-I      intronic chr1:53439471(+) A-I      intronic chr1:53500721(+) A-I      intronic chr1:53483591(+) A-I      intronic chr1:53427667(+) A-I      intronic chr1:53467804(+) A-I      intronic chr1:53479707(+) A-I      intronic chr1:53466552(+) A-I      intronic chr1:53483583(+) A-I      intronic chr1:53396132(+) A-I      intronic chr1:53407260(+) A-I      intronic chr1:53433713(+) A-I      intronic chr1:53395569(+) A-I      intronic chr1:53424068(+) A-I      intronic chr1:53509761(+) A-I      intronic chr1:53439521(+) A-I      intronic chr1:53485676(+) A-I      intronic chr1:53394294(+) A-I      intronic chr1:53433876(+) A-I      intronic chr1:53492424(+) A-I      intronic chr1:53394394(+) A-I      intronic chr1:53394364(+) A-I      intronic chr1:53469271(+) A-I      intronic chr1:53427648(+) A-I      intronic chr1:53394293(+) A-I      intronic chr1:53394297(+) A-I      intronic chr1:53396161(+) A-I      intronic chr1:53419881(+) A-I      intronic chr1:53504324(+) A-I      intronic chr1:53433743(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SCP2	chr1:53481662(+) A-I intron -    15342557 chr1:53483407(+) A-I intron -    15342557 chr1:53483566(+) A-I intron -    15342557 chr1:53483583(+) A-I intron -    15342557 chr1:53483590(+) A-I intron -    15342557 chr1:53483591(+) A-I intron -    15342557 chr1:53483607(+) A-I intron -    15342557 chr1:53483652(+) A-I intron -    15342557 chr1:53483656(+) A-I intron -    15342557 chr1:53484218(+) A-I intron -    15342557 chr1:53484302(+) A-I intron -    15342557 chr1:53484306(+) A-I intron -    15342557 chr1:53484324(+) A-I intron -    15342557 chr1:53484325(+) A-I intron -    15342557 chr1:53484345(+) A-I intron -    15342557 chr1:53484368(+) A-I intron -    15342557 chr1:53484392(+) A-I intron -    15342557 chr1:53395569(+) A-G intron -    22484847 chr1:53427614(+) A-G intron -    22484847 chr1:53429991(+) A-G intron -    22484847 chr1:53430508(+) A-G intron -    22484847 chr1:53430552(+) A-G intron -    22484847 chr1:53433742(+) A-G intron -    22484847 chr1:53433743(+) A-G intron -    22484847 chr1:53433747(+) A-G intron -    22484847 chr1:53433752(+) A-G intron -    22484847 chr1:53433887(+) A-G intron -    22484847 chr1:53456297(+) T-C intron -    22484847 chr1:53485676(+) A-G intron -    22484847 chr1:53492225(+) A-G intron -    22484847 chr1:53492335(+) A-G intron -    22484847 chr1:53492359(+) A-G intron -    22484847 chr1:53492400(+) A-G intron -    22484847 chr1:53492405(+) A-G intron -    22484847 chr1:53492704(+) A-G intron -    22484847 chr1:53502632(+) A-G intron -    22484847 chr1:53503484(+) A-G intron -    22484847 chr1:53503695(+) A-G intron -    22484847 chr1:53503721(+) A-G intron -    22484847 chr1:53509836(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SCP2	chr1:53459373-53459374(+) m6A 3'UTR//intron       - chr1:53459389-53459390(+) m6A 3'UTR//intron       - chr1:53459394-53459395(+) m6A 3'UTR//intron       - chr1:53460512-53460513(+) m6A 3'UTR//intron       22575960//22608085 chr1:53460530-53460531(+) m6A 3'UTR//intron       22575960//22608085 chr1:53460603-53460604(+) m6A 3'UTR//intron       22575960//22608085 chr1:53460610-53460611(+) m6A 3'UTR//intron       22575960//22608085 chr1:53460617-53460618(+) m6A 3'UTR//intron       22575960//22608085 chr1:53460654-53460655(+) m6A 3'UTR//intron       22575960//22608085 chr1:53460659-53460660(+) m6A 3'UTR//intron       22575960//22608085 chr1:53460968-53460969(+) m6A 3'UTR//intron       22608085 chr1:53460979-53460980(+) m6A 3'UTR//intron       22608085 chr1:53461046-53461047(+) m6A 3'UTR//intron       22608085 chr1:53461055-53461056(+) m6A 3'UTR//intron       22608085 chr1:53461061-53461062(+) m6A 3'UTR//intron       22608085 chr1:53461152-53461153(+) m6A 3'UTR//intron       22608085 chr1:53461365-53461366(+) m6A 3'UTR//intron       - chr1:53461371-53461372(+) m6A 3'UTR//intron       - chr1:53461412-53461413(+) m6A 3'UTR//intron       - chr1:53480580-53480581(+) m6A 3'UTR//CDS       24981863 chr1:53493650-53493651(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr1:53493670-53493671(+) Y 3'UTR//CDS//intron       25219674//26075521 chr1:53493733-53493734(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr1:53504596-53504597(+) m6A 3'UTR//CDS//intron       24981863//27773535 chr1:53516379-53516380(+) m6A 3'UTR       27773535 chr1:53516451-53516452(+) Y 3'UTR       25219674 chr1:53516455-53516456(+) m6A 3'UTR       26404942//27773535 chr1:53516461-53516462(+) m6A 3'UTR       26404942//27773535 chr1:53516900-53516901(+) m6A 3'UTR       27773535 chr1:53516950-53516951(+) m6A 3'UTR       27773535 chr1:53517026-53517027(+) m6A 3'UTR       27773535 chr1:53517049-53517050(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	SCP2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: SCP2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).