Basic Information:

  VIRBase ID:  

VHID00280269

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          RCN2:  NM_002902     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	RCN2
miRBase Accession/Entrez ID	MIMAT0000996	5955
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	E6BP//ERC-55//ERC55//TCBP49

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RCN2	chr15:77235073(+) A-I      intronic chr15:77232989(+) A-I      intronic chr15:77226722(+) A-I      intronic chr15:77235118(+) A-I      intronic chr15:77238838(+) A-I      intronic chr15:77230001(+) A-I      intronic chr15:77227551(+) A-I      intronic chr15:77227550(+) A-I      intronic chr15:77227515(+) A-I      intronic chr15:77227511(+) A-I      intronic chr15:77227504(+) A-I      intronic chr15:77227446(+) A-I      intronic chr15:77226744(+) A-I      intronic chr15:77226624(+) A-I      intronic chr15:77226584(+) A-I      intronic chr15:77227454(+) A-I      intronic chr15:77235575(+) A-I      intronic chr15:77235127(+) A-I      intronic chr15:77235106(+) A-I      intronic chr15:77235087(+) A-I      intronic chr15:77235084(+) A-I      intronic chr15:77235062(+) A-I      intronic chr15:77233474(+) A-I      intronic chr15:77233468(+) A-I      intronic chr15:77232567(+) A-I      intronic chr15:77231497(+) A-I      intronic chr15:77231306(+) A-I      intronic chr15:77231274(+) A-I      intronic chr15:77231258(+) A-I      intronic chr15:77226682(+) A-I      intronic chr15:77227544(+) A-I      intronic chr15:77238615(+) A-I      intronic chr15:77235054(+) A-I      intronic chr15:77226650(+) A-I      intronic chr15:77233565(+) A-I      intronic chr15:77229848(+) A-I      intronic chr15:77229849(+) A-I      intronic chr15:77235173(+) A-I      intronic chr15:77239002(+) A-I      intronic chr15:77231246(+) A-I      intronic chr15:77238972(+) A-I      intronic chr15:77227609(+) A-I      intronic chr15:77231327(+) A-I      intronic chr15:77235134(+) A-I      intronic chr15:77226585(+) A-I      intronic chr15:77233475(+) A-I      intronic chr15:77235199(+) A-I      intronic chr15:77232983(+) A-I      intronic chr15:77226503(+) A-I      intronic chr15:77235594(+) A-I      intronic chr15:77227461(+) A-I      intronic chr15:77227554(+) A-I      intronic chr15:77231298(+) A-I      intronic chr15:77235123(+) A-I      intronic chr15:77235006(+) A-I      intronic chr15:77231270(+) A-I      intronic chr15:77227648(+) A-I      intronic chr15:77227624(+) A-I      intronic chr15:77228788(+) A-I      intronic chr15:77233237(+) A-I      intronic chr15:77226745(+) A-I      intronic chr15:77233007(+) A-I      intronic chr15:77231804(+) A-I      intronic chr15:77235255(+) A-I      intronic chr15:77231275(+) A-I      intronic chr15:77226562(+) A-I      intronic chr15:77235228(+) A-I      intronic chr15:77235205(+) A-I      intronic chr15:77226549(+) A-I      intronic chr15:77227605(+) A-I      intronic chr15:77232975(+) A-I      intronic chr15:77227499(+) A-I      intronic chr15:77233501(+) A-I      intronic chr15:77235137(+) A-I      intronic chr15:77229963(+) A-I      intronic chr15:77235634(+) A-I      intronic chr15:77226614(+) A-I      intronic chr15:77231535(+) A-I      intronic chr15:77235229(+) A-I      intronic chr15:77235107(+) A-I      intronic chr15:77235595(+) A-I      intronic chr15:77233449(+) A-I      intronic chr15:77235015(+) A-I      intronic chr15:77227558(+) A-I      intronic chr15:77235633(+) A-I      intronic chr15:77227508(+) A-I      intronic chr15:77231309(+) A-I      intronic chr15:77229914(+) A-I      intronic chr15:77233504(+) A-I      intronic chr15:77231800(+) A-I      intronic chr15:77232564(+) A-I      intronic chr15:77229946(+) A-I      intronic chr15:77235586(+) A-I      intronic chr15:77227488(+) A-I      intronic chr15:77226602(+) A-I      intronic chr15:77227449(+) A-I      intronic chr15:77235033(+) A-I      intronic chr15:77226659(+) A-I      intronic chr15:77226665(+) A-I      intronic chr15:77226651(+) A-I      intronic chr15:77235027(+) A-I      intronic chr15:77232574(+) A-I      intronic chr15:77232624(+) A-I      intronic chr15:77232909(+) A-I      intronic chr15:77230023(+) A-I      intronic chr15:77227518(+) A-I      intronic chr15:77226610(+) A-I      intronic chr15:77227411(+) A-I      intronic chr15:77235101(+) A-I      intronic chr15:77235180(+) A-I      intronic chr15:77233540(+) A-I      intronic chr15:77226543(+) A-I      intronic chr15:77235082(+) A-I      intronic chr15:77231795(+) A-I      intronic chr15:77226704(+) A-I      intronic chr15:77226611(+) A-I      intronic chr15:77227388(+) A-I      intronic chr15:77227598(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RCN2	chr15:77235027(+) A-I intron -    15342557 chr15:77235054(+) A-I intron -    15342557 chr15:77235101(+) A-I intron -    15342557 chr15:77235107(+) A-I intron -    15342557 chr15:77235123(+) A-I intron -    15342557 chr15:77235173(+) A-I intron -    15342557 chr15:77235199(+) A-I intron -    15342557 chr15:77235228(+) A-I intron -    15342557 chr15:77235594(+) A-I intron -    15342557 chr15:77235595(+) A-I intron -    15342557 chr15:77235634(+) A-I intron -    15342557 chr15:77235586(+) A-I intron -    21960545 chr15:77226650(+) A-G intron -    22484847 chr15:77235586(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RCN2	chr15:77224001-77224002(+) m6A 5'UTR       24981863 chr15:77224200-77224201(+) m6A CDS       24209618//22575960 chr15:77224724-77224725(+) m6A CDS//intron       24981863//26404942 chr15:77224751-77224752(+) m6A CDS//intron       24981863//26404942 chr15:77224783-77224784(+) m6A CDS//intron       24981863//26404942 chr15:77227870-77227871(+) m6A CDS//intron       24981863//26404942 chr15:77239790-77239791(+) m6A 3'UTR//CDS//exon       22575960 chr15:77241480-77241481(+) m6A CDS       24981863 chr15:77241486-77241487(+) m6A CDS       24981863 chr15:77241867-77241868(+) m6A 3'UTR       26404942//27773535 chr15:77241893-77241894(+) m6A 3'UTR       27773535 chr15:77241965-77241966(+) m6A 3'UTR       27773535 chr15:77241974-77241975(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	RCN2	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: RCN2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).