Basic Information:

  VIRBase ID:  

VHID00280187

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          PPP2R2A:  NM_002717     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	PPP2R2A
miRBase Accession/Entrez ID	MIMAT0000996	5520
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	B55A//B55ALPHA//PR52A//PR55A//PR55alpha

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PPP2R2A	chr8:26202503(+) A-I      intronic chr8:26163888(+) A-I      intronic chr8:26163887(+) A-I      intronic chr8:26163841(+) A-I      intronic chr8:26163782(+) A-I      intronic chr8:26163777(+) A-I      intronic chr8:26163758(+) A-I      intronic chr8:26159050(+) A-I      intronic chr8:26212838(+) A-I      intronic chr8:26158355(+) A-I      intronic chr8:26158347(+) A-I      intronic chr8:26158174(+) A-I      intronic chr8:26200605(+) A-I      intronic chr8:26156683(+) A-I      intronic chr8:26156656(+) A-I      intronic chr8:26154700(+) A-I      intronic chr8:26226843(+) A-I      intronic chr8:26208489(+) A-I      intronic chr8:26226806(+) A-I      intronic chr8:26226804(+) A-I      intronic chr8:26226782(+) A-I      intronic chr8:26227119(+) A-I      intronic chr8:26226774(+) A-I      intronic chr8:26226766(+) A-I      intronic chr8:26158948(+) A-I      intronic chr8:26202522(+) A-I      intronic chr8:26173660(+) A-I      intronic chr8:26202509(+) A-I      intronic chr8:26202507(+) A-I      intronic chr8:26163872(+) A-I      intronic chr8:26163871(+) A-I      intronic chr8:26163736(+) A-I      intronic chr8:26226242(+) A-I      intronic chr8:26226183(+) A-I      intronic chr8:26226178(+) A-I      intronic chr8:26226170(+) A-I      intronic chr8:26213336(+) A-I      intronic chr8:26213139(+) A-I      intronic chr8:26213126(+) A-I      intronic chr8:26213125(+) A-I      intronic chr8:26213034(+) A-I      intronic chr8:26212837(+) A-I      intronic chr8:26163737(+) A-I      intronic chr8:26208463(+) A-I      intronic chr8:26207621(+) A-I      intronic chr8:26207603(+) A-I      intronic chr8:26203917(+) A-I      intronic chr8:26203710(+) A-I      intronic chr8:26200991(+) A-I      intronic chr8:26200987(+) A-I      intronic chr8:26200919(+) A-I      intronic chr8:26167668(+) A-I      intronic chr8:26194291(+) A-I      intronic chr8:26194290(+) A-I      intronic chr8:26192206(+) A-I      intronic chr8:26192130(+) A-I      intronic chr8:26192050(+) A-I      intronic chr8:26226895(+) A-I      intronic chr8:26183493(+) A-I      intronic chr8:26183481(+) A-I      intronic chr8:26183469(+) A-I      intronic chr8:26183451(+) A-I      intronic chr8:26226888(+) A-I      intronic chr8:26167650(+) A-I      intronic chr8:26167521(+) A-I      intronic chr8:26166503(+) A-I      intronic chr8:26166456(+) A-I      intronic chr8:26158988(+) A-I      intronic chr8:26166648(+) A-I      intronic chr8:26226471(+) A-I      intronic chr8:26200574(+) A-I      intronic chr8:26193731(+) A-I      intronic chr8:26226926(+) A-I      intronic chr8:26200610(+) A-I      intronic chr8:26208182(+) A-I      intronic chr8:26227182(+) A-I      intronic chr8:26226462(+) A-I      intronic chr8:26192182(+) A-I      intronic chr8:26212853(+) A-I      intronic chr8:26207604(+) A-I      intronic chr8:26208396(+) A-I      intronic chr8:26208200(+) A-I      intronic chr8:26158934(+) A-I      intronic chr8:26189623(+) A-I      intronic chr8:26166651(+) A-I      intronic chr8:26207706(+) A-I      intronic chr8:26213260(+) A-I      intronic chr8:26163716(+) A-I      intronic chr8:26163885(+) A-I      intronic chr8:26200538(+) A-I      intronic chr8:26183553(+) A-I      intronic chr8:26212843(+) A-I      intronic chr8:26213218(+) A-I      intronic chr8:26158117(+) A-I      intronic chr8:26200573(+) A-I      intronic chr8:26200593(+) A-I      intronic chr8:26158125(+) A-I      intronic chr8:26226226(+) A-I      intronic chr8:26167676(+) A-I      intronic chr8:26193824(+) A-I      intronic chr8:26200907(+) A-I      intronic chr8:26227107(+) A-I      intronic chr8:26226152(+) A-I      intronic chr8:26227072(+) A-I      intronic chr8:26166613(+) A-I      intronic chr8:26163913(+) A-I      intronic chr8:26201090(+) A-I      intronic chr8:26200512(+) A-I      intronic chr8:26159014(+) A-I      intronic chr8:26158288(+) A-I      intronic chr8:26213266(+) A-I      intronic chr8:26226468(+) A-I      intronic chr8:26219388(+) A-I      intronic chr8:26159037(+) A-I      intronic chr8:26193928(+) A-I      intronic chr8:26193929(+) A-I      intronic chr8:26193842(+) A-I      intronic chr8:26203743(+) A-I      intronic chr8:26164304(+) A-I      intronic chr8:26227036(+) A-I      intronic chr8:26158978(+) A-I      intronic chr8:26158935(+) A-I      intronic chr8:26158996(+) A-I      intronic chr8:26158371(+) A-I      intronic chr8:26208183(+) A-I      intronic chr8:26226210(+) A-I      intronic chr8:26201005(+) A-I      intronic chr8:26167543(+) A-I      intronic chr8:26183614(+) A-I      intronic chr8:26226443(+) A-I      intronic chr8:26200974(+) A-I      intronic chr8:26200479(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PPP2R2A	chr8:26227059(+) A-I intron -    15342557 chr8:26227062(+) A-I intron -    15342557 chr8:26227072(+) A-I intron -    15342557 chr8:26227073(+) A-I intron -    15342557 chr8:26227107(+) A-I intron -    15342557 chr8:26227115(+) A-I intron -    15342557 chr8:26227122(+) A-I intron -    15342557 chr8:26227155(+) A-I intron -    15342557 chr8:26227182(+) A-I intron -    15342557 chr8:26205952(+) A-G intron -    22484847 chr8:26158928(+) A-G intron -    22484847 chr8:26158934(+) A-G intron -    22484847 chr8:26158935(+) A-G intron -    22484847 chr8:26158978(+) A-G intron -    22484847 chr8:26158994(+) A-G intron -    22484847 chr8:26158996(+) A-G intron -    22484847 chr8:26163716(+) A-G intron -    22484847 chr8:26167544(+) A-G intron -    22484847 chr8:26167635(+) A-G intron -    22484847 chr8:26167676(+) A-G intron -    22484847 chr8:26167701(+) G-A intron -    22484847 chr8:26170683(+) A-G intron -    22484847 chr8:26187823(+) C-T intron -    22484847 chr8:26187825(+) T-C intron -    22484847 chr8:26187832(+) T-C intron -    22484847 chr8:26200512(+) A-G intron -    22484847 chr8:26200530(+) A-G intron -    22484847 chr8:26200907(+) A-G intron -    22484847 chr8:26200974(+) A-G intron -    22484847 chr8:26207680(+) A-G intron -    22484847 chr8:26208396(+) A-G intron -    22484847 chr8:26212843(+) A-G intron -    22484847 chr8:26213260(+) A-G intron -    22484847 chr8:26226286(+) A-G intron -    22484847 chr8:26226471(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PPP2R2A	chr8:26212045-26212046(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24981863 chr8:26227738-26227739(+) m6A CDS//exon       27773535 chr8:26227825-26227826(+) m6A CDS//exon       24981863//27773535//22608085 chr8:26227894-26227895(+) m6A CDS//exon       24209618//24981863//26404942//22608085 chr8:26227915-26227916(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22608085 chr8:26227951-26227952(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//22608085 chr8:26228191-26228192(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:26228201-26228202(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:26228257-26228258(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr8:26228410-26228411(+) m6A 3'UTR//exon       24284625//24981863 chr8:26228543-26228544(+) m6A 3'UTR//exon       27773535 chr8:26228613-26228614(+) m6A 3'UTR//exon       27773535 chr8:26229394-26229395(+) m6A 3'UTR       24981863//22608085 chr8:26229415-26229416(+) m6A 3'UTR       24981863//22608085 chr8:26229440-26229441(+) m6A 3'UTR       24981863//22608085 chr8:26229485-26229486(+) m6A 3'UTR       24981863//22608085 chr8:26229515-26229516(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	PPP2R2A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: PPP2R2A

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22291592	Target region	CDS
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).