Detail Information

Basic Information:


  VIRBase ID:  

VHID00280058

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:           MYC:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-2-5p MYC
miRBase
Accession/Entrez ID		 MIMAT0000996 4609
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - bHLHe39//c-Myc//MRTL//MYCC

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MYC
chr8:128752212(+) C-T intron -    22484847
chr8:128752228(+) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MYC
chr8:128747856-128747857(+) m6A 5'UTR       24284625
chr8:128747998-128747999(+) m6A 5'UTR       24284625
chr8:128748018-128748019(+) m6A 5'UTR       24284625
chr8:128748315-128748316(+) m6A 5'UTR//intron       24284625//24981863
chr8:128748596-128748597(+) Y 5'UTR//intron       26075521
chr8:128748673-128748674(+) m6A 5'UTR//intron       24284625//24981863//26404942//22575960
chr8:128748711-128748712(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748776-128748777(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748798-128748799(+) m6A 5'UTR       24284625//24981863//26404942//22575960
chr8:128748864-128748865(+) m6A 5'UTR//CDS       24284625//24981863//22575960
chr8:128750539-128750540(+) m6A 5'UTR//CDS       24284625//24981863//26404942//22575960
chr8:128750596-128750597(+) m6A CDS       24284625//24981863//26404942//22575960
chr8:128750761-128750762(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750833-128750834(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750842-128750843(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750874-128750875(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750887-128750888(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750902-128750903(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085
chr8:128750980-128750981(+) m6A CDS       24284625//24981863//26404942//22575960//22608085
chr8:128750995-128750996(+) m6A CDS       24284625//24981863//26404942//22575960//22608085
chr8:128751142-128751143(+) m6A CDS       24284625//22575960
chr8:128751237-128751238(+) m6A CDS       24284625//22575960
chr8:128752648-128752649(+) m6A CDS       24284625//22575960
chr8:128752750-128752751(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr8:128752836-128752837(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752866-128752867(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752885-128752886(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752886-128752887(+) Cm CDS       -
chr8:128752929-128752930(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128752955-128752956(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128753040-128753041(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr8:128753136-128753137(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753158-128753159(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753167-128753168(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753173-128753174(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753179-128753180(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753190-128753191(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753261-128753262(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753316-128753317(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753341-128753342(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr8:128753356-128753357(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:128753373-128753374(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-2-5p
Exosome B cell line (Raji)     21505438
MYC
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: MYC

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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