Basic Information:

  VIRBase ID:  

VHID00279982

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          KPNB1:  NM_001276453     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	KPNB1
miRBase Accession/Entrez ID	MIMAT0000996	3837
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMB1//Impnb//IPO1//IPOB//NTF97

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KPNB1	chr17:45751171(+) A-I      intronic chr17:45751207(+) A-I      intronic chr17:45749471(+) A-I      intronic chr17:45749434(+) A-I      intronic chr17:45749068(+) A-I      intronic chr17:45730747(+) A-I      intronic chr17:45748423(+) A-I      intronic chr17:45748466(+) A-I      intronic chr17:45748463(+) A-I      intronic chr17:45748457(+) A-I      intronic chr17:45748383(+) A-I      intronic chr17:45733729(+) A-I      intronic chr17:45730753(+) A-I      intronic chr17:45733715(+) A-I      intronic chr17:45731730(+) A-I      intronic chr17:45730817(+) A-I      intronic chr17:45748529(+) A-I      intronic chr17:45730805(+) A-I      intronic chr17:45749621(+) A-I      intronic chr17:45749581(+) A-I      intronic chr17:45749426(+) A-I      intronic chr17:45754750(+) A-I      intronic chr17:45749442(+) A-I      intronic chr17:45748476(+) A-I      intronic chr17:45749074(+) A-I      intronic chr17:45748388(+) A-I      intronic chr17:45733680(+) A-I      intronic chr17:45748422(+) A-I      intronic chr17:45748464(+) A-I      intronic chr17:45730791(+) A-I      intronic chr17:45744085(+) A-I      intronic chr17:45748389(+) A-I      intronic chr17:45741195(+) A-I      intronic chr17:45740145(+) A-I      intronic chr17:45749484(+) A-I      intronic chr17:45746630(+) A-I      intronic chr17:45748460(+) A-I      intronic chr17:45748502(+) A-I      intronic chr17:45733869(+) A-I      intronic chr17:45751154(+) A-I      intronic chr17:45751567(+) A-I      intronic chr17:45751161(+) A-I      intronic chr17:45751167(+) A-I      intronic chr17:45751170(+) A-I      intronic chr17:45751582(+) A-I      intronic chr17:45741203(+) A-I      intronic chr17:45751169(+) A-I      intronic chr17:45751135(+) A-I      intronic chr17:45741160(+) A-I      intronic chr17:45751547(+) A-I      intronic chr17:45751501(+) A-I      intronic chr17:45749555(+) A-I      intronic chr17:45751506(+) A-I      intronic chr17:45753313(+) A-I      intronic chr17:45733793(+) A-I      intronic chr17:45749472(+) A-I      intronic chr17:45730749(+) A-I      intronic chr17:45744121(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KPNB1	chr17:45751169(+) A-I intron -    22327324 chr17:45751170(+) A-I intron -    22327324 chr17:45751501(+) A-I intron -    22327324 chr17:45751506(+) A-I intron -    22327324 chr17:45751567(+) A-I intron -    21960545 chr17:45751506(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KPNB1	chr17:45726881-45726882(+) m6A 5'UTR       24981863 chr17:45727201-45727202(+) m6A 5'UTR       24981863 chr17:45727446-45727447(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960 chr17:45727459-45727460(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960 chr17:45727637-45727638(+) m6A CDS//exon//intron       25456834//22575960 chr17:45730105-45730106(+) m6A 5'UTR//CDS//exon       26404942 chr17:45730147-45730148(+) m6A 5'UTR//CDS//exon       26404942 chr17:45730162-45730163(+) Am 5'UTR//CDS//exon       - chr17:45730237-45730238(+) m6A 5'UTR//CDS//exon       26404942 chr17:45734234-45734235(+) m6A 5'UTR//CDS//exon       26404942 chr17:45734249-45734250(+) m6A 5'UTR//CDS//exon       26404942 chr17:45734313-45734314(+) m6A 5'UTR//CDS//exon       26404942//22575960 chr17:45734326-45734327(+) m6A 5'UTR//CDS//exon       26404942//22575960 chr17:45734358-45734359(+) m6A 5'UTR//CDS//exon       26404942//22575960 chr17:45735988-45735989(+) m6A CDS//exon       26404942 chr17:45736012-45736013(+) m6A CDS//exon       26404942 chr17:45739587-45739588(+) m6A exon//intron       22575960 chr17:45742430-45742431(+) m6A CDS//intron       26404942 chr17:45742509-45742510(+) m6A CDS//intron       26404942 chr17:45742520-45742521(+) m6A CDS//intron       26404942 chr17:45745579-45745580(+) m6A CDS       26404942//22575960 chr17:45745670-45745671(+) m6A CDS       26404942//22575960 chr17:45745681-45745682(+) m6A CDS       26404942//22575960 chr17:45745739-45745740(+) m6A CDS       26404942 chr17:45745760-45745761(+) m6A CDS       26404942 chr17:45747074-45747075(+) m6A CDS       26404942 chr17:45747109-45747110(+) m6A CDS       26404942 chr17:45750522-45750523(+) Cm CDS//exon       - chr17:45753814-45753815(+) m6A CDS//exon       26404942//22575960 chr17:45754416-45754417(+) m6A CDS//exon       22575960 chr17:45755550-45755551(+) m6A CDS//exon       26404942//22575960 chr17:45755677-45755678(+) m6A CDS//exon       26404942//22575960 chr17:45757491-45757492(+) m6A CDS//exon       24981863//27773535 chr17:45757875-45757876(+) m6A CDS//exon       24981863//26404942//27773535 chr17:45757957-45757958(+) Gm CDS//exon       - chr17:45757967-45757968(+) m6A CDS//exon       24981863//26404942//27773535 chr17:45757982-45757983(+) m6A CDS//exon       24981863//26404942//27773535 chr17:45758008-45758009(+) m6A CDS//exon       24981863//26404942//27773535 chr17:45758017-45758018(+) m6A CDS//exon       24981863//26404942//27773535 chr17:45758025-45758026(+) m6A CDS//exon       24284625//24981863//26404942//27773535 chr17:45759799-45759800(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr17:45759831-45759832(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22575960 chr17:45759902-45759903(+) m6A 3'UTR//exon       24284625//24981863//27773535//22575960//22608085 chr17:45759994-45759995(+) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr17:45760027-45760028(+) m6A 3'UTR       24284625//25456834//24981863//27773535//22575960//22608085 chr17:45760151-45760152(+) m6A 3'UTR       25456834 chr17:45760484-45760485(+) m6A 3'UTR//intron       27773535 chr17:45760571-45760572(+) m6A 3'UTR//intron       24981863//27773535 chr17:45760683-45760684(+) m6A 3'UTR//intron       24981863//27773535 chr17:45760739-45760740(+) m6A 3'UTR//intron       24981863//27773535//22608085 chr17:45760748-45760749(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr17:45760768-45760769(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr17:45760902-45760903(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr17:45760917-45760918(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr17:45760924-45760925(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr17:45760951-45760952(+) m6A 3'UTR//intron       27773535 chr17:45760973-45760974(+) m6A 3'UTR//intron       27773535 chr17:45761000-45761001(+) m6A 3'UTR//intron       27773535 chr17:45762678-45762679(+) m6A 3'UTR       27773535 chr17:45762713-45762714(+) m6A 3'UTR       27773535 chr17:45762778-45762779(+) m6A 3'UTR       27773535 chr17:45762787-45762788(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	KPNB1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: KPNB1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	CDS
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).