Basic Information:

  VIRBase ID:  

VHID00279955

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          ITGAV:  NM_002210     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	ITGAV
miRBase Accession/Entrez ID	MIMAT0000996	3685
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD51//MSK8//VNRA//VTNR

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ITGAV	chr2:187527238(+) A-I      intronic chr2:187527237(+) A-I      intronic chr2:187527222(+) A-I      intronic chr2:187527216(+) A-I      intronic chr2:187527206(+) A-I      intronic chr2:187527205(+) A-I      intronic chr2:187527195(+) A-I      intronic chr2:187527191(+) A-I      intronic chr2:187493603(+) A-I      intronic chr2:187493590(+) A-I      intronic chr2:187493324(+) A-I      intronic chr2:187493641(+) A-I      intronic chr2:187493638(+) A-I      intronic chr2:187493634(+) A-I      intronic chr2:187493626(+) A-I      intronic chr2:187493601(+) A-I      intronic chr2:187493585(+) A-I      intronic chr2:187493583(+) A-I      intronic chr2:187493581(+) A-I      intronic chr2:187493306(+) A-I      intronic chr2:187493305(+) A-I      intronic chr2:187493302(+) A-I      intronic chr2:187493294(+) A-I      intronic chr2:187493276(+) A-I      intronic chr2:187493275(+) A-I      intronic chr2:187493303(+) A-I      intronic chr2:187493301(+) A-I      intronic chr2:187493298(+) A-I      intronic chr2:187493291(+) A-I      intronic chr2:187508891(+) A-I      intronic chr2:187508750(+) A-I      intronic chr2:187513547(+) A-I      intronic chr2:187493567(+) A-I      intronic chr2:187493607(+) A-I      intronic chr2:187468800(+) A-I      intronic chr2:187508740(+) A-I      intronic chr2:187508745(+) A-I      intronic chr2:187513608(+) A-I      intronic chr2:187513553(+) A-I      intronic chr2:187513550(+) A-I      intronic chr2:187513549(+) A-I      intronic chr2:187493569(+) A-I      intronic chr2:187493565(+) A-I      intronic chr2:187493369(+) A-I      intronic chr2:187493368(+) A-I      intronic chr2:187455371(+) A-I      intronic chr2:187527493(+) A-I      intronic chr2:187527480(+) A-I      intronic chr2:187527462(+) A-I      intronic chr2:187527432(+) A-I      intronic chr2:187527426(+) A-I      intronic chr2:187527252(+) A-I      intronic chr2:187527251(+) A-I      intronic chr2:187527240(+) A-I      intronic chr2:187527239(+) A-I      intronic chr2:187508675(+) A-I      intronic chr2:187510517(+) A-I      intronic chr2:187510507(+) A-I      intronic chr2:187510456(+) A-I      intronic chr2:187510600(+) A-I      intronic chr2:187510440(+) A-I      intronic chr2:187508682(+) A-I      intronic chr2:187518895(+) A-I      intronic chr2:187518898(+) A-I      intronic chr2:187518901(+) A-I      intronic chr2:187518904(+) A-I      intronic chr2:187508871(+) A-I      intronic chr2:187496589(+) A-I      intronic chr2:187496572(+) A-I      intronic chr2:187476222(+) A-I      intronic chr2:187476216(+) A-I      intronic chr2:187467510(+) A-I      intronic chr2:187467356(+) A-I      intronic chr2:187508764(+) A-I      intronic chr2:187508788(+) A-I      intronic chr2:187509273(+) A-I      intronic chr2:187508810(+) A-I      intronic chr2:187517737(+) A-I      intronic chr2:187517685(+) A-I      intronic chr2:187517100(+) A-I      intronic chr2:187510627(+) A-I      intronic chr2:187510605(+) A-I      intronic chr2:187519005(+) A-I      intronic chr2:187510588(+) A-I      intronic chr2:187510578(+) A-I      intronic chr2:187510552(+) A-I      intronic chr2:187509253(+) A-I      intronic chr2:187509192(+) A-I      intronic chr2:187509198(+) A-I      intronic chr2:187510539(+) A-I      intronic chr2:187496592(+) A-I      intronic chr2:187466081(+) A-I      intronic chr2:187467525(+) A-I      intronic chr2:187510620(+) A-I      intronic chr2:187510624(+) A-I      intronic chr2:187468615(+) A-I      intronic chr2:187467350(+) A-I      intronic chr2:187508845(+) A-I      intronic chr2:187510649(+) A-I      intronic chr2:187465607(+) A-I      intronic chr2:187466067(+) A-I      intronic chr2:187509152(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ITGAV	chr2:187493271(+) A-I intron -    21960545 chr2:187493272(+) A-I intron -    21960545 chr2:187493352(+) A-I intron -    21960545 chr2:187493355(+) A-I intron -    21960545 chr2:187493549(+) A-I intron -    21960545 chr2:187493572(+) A-I intron -    21960545 chr2:187493582(+) A-I intron -    21960545 chr2:187493588(+) A-I intron -    21960545 chr2:187493271(+) A-G intron -    22484847 chr2:187493272(+) A-G intron -    22484847 chr2:187493582(+) A-G intron -    22484847 chr2:187493588(+) A-G intron -    22484847 chr2:187467350(+) A-G intron -    22484847 chr2:187467351(+) A-G intron -    22484847 chr2:187468615(+) A-G intron -    22484847 chr2:187497804(+) A-T intron -    22484847 chr2:187493352(+) A-G intron -    22484847 chr2:187493549(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ITGAV	chr2:187454835-187454836(+) m6A 5'UTR       24209618//25456834//24981863 chr2:187455130-187455131(+) m6A CDS       24209618//22575960 chr2:187455171-187455172(+) m6A CDS       24209618//22575960 chr2:187521091-187521092(+) m6A CDS       26404942 chr2:187542083-187542084(+) m6A 3'UTR       26404942 chr2:187544655-187544656(+) m6A 3'UTR       26404942 chr2:187544676-187544677(+) m6A 3'UTR       26404942 chr2:187545386-187545387(+) m6A 3'UTR       27773535 chr2:187545496-187545497(+) m6A 3'UTR       27773535 chr2:187545555-187545556(+) m6A 3'UTR       27773535 chr2:187545609-187545610(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	ITGAV	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: ITGAV

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).