Detail Information

Basic Information:


  VIRBase ID:  

VHID00279837

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:           GDI2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-2-5p GDI2
miRBase
Accession/Entrez ID		 MIMAT0000996 2665
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - HEL-S-46e//RABGDIB

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR GDI2
chr10:5851108(-) A-I      intronic
chr10:5846168(-) A-I      intronic
chr10:5845250(-) A-I      intronic
chr10:5850236(-) A-I      intronic
chr10:5822109(-) A-I      intronic
chr10:5828357(-) A-I      intronic
chr10:5847449(-) A-I      intronic
chr10:5822134(-) A-I      intronic
chr10:5828311(-) A-I      intronic
chr10:5850097(-) A-I      intronic
chr10:5850131(-) A-I      intronic
chr10:5850193(-) A-I      intronic
chr10:5846979(-) A-I      intronic
chr10:5851126(-) A-I      intronic
chr10:5851125(-) A-I      intronic
chr10:5846976(-) A-I      intronic
chr10:5846974(-) A-I      intronic
chr10:5850539(-) A-I      intronic
chr10:5846973(-) A-I      intronic
chr10:5843556(-) A-I      intronic
chr10:5828343(-) A-I      intronic
chr10:5821733(-) A-I      intronic
chr10:5821719(-) A-I      intronic
chr10:5821371(-) A-I      intronic
chr10:5817182(-) A-I      intronic
chr10:5846181(-) A-I      intronic
chr10:5821347(-) A-I      intronic
chr10:5821305(-) A-I      intronic
chr10:5821279(-) A-I      intronic
chr10:5846217(-) A-I      intronic
chr10:5846269(-) A-I      intronic
chr10:5846276(-) A-I      intronic
chr10:5812313(-) A-I      intronic
chr10:5812298(-) A-I      intronic
chr10:5847468(-) A-I      intronic
chr10:5821784(-) A-I      intronic
chr10:5843744(-) A-I      intronic
chr10:5847600(-) A-I      intronic
chr10:5817168(-) A-I      intronic
chr10:5847421(-) A-I      intronic
chr10:5842999(-) A-I      intronic
chr10:5844319(-) A-I      intronic
chr10:5843888(-) A-I      intronic
chr10:5847454(-) A-I      intronic
chr10:5846153(-) A-I      intronic
chr10:5843134(-) A-I      intronic
chr10:5847543(-) A-I      intronic
chr10:5843782(-) A-I      intronic
chr10:5821883(-) A-I      intronic
chr10:5847482(-) A-I      intronic
chr10:5837802(-) A-I      intronic
chr10:5843517(-) A-I      intronic
chr10:5846804(-) A-I      intronic
chr10:5843527(-) A-I      intronic
chr10:5835213(-) A-I      intronic
chr10:5846125(-) A-I      intronic
chr10:5835069(-) A-I      intronic
chr10:5846124(-) A-I      intronic
chr10:5845365(-) A-I      intronic
chr10:5845355(-) A-I      intronic
chr10:5848293(-) A-I      intronic
chr10:5845354(-) A-I      intronic
chr10:5845245(-) A-I      intronic
chr10:5845241(-) A-I      intronic
chr10:5837185(-) A-I      intronic
chr10:5845237(-) A-I      intronic
chr10:5845228(-) A-I      intronic
chr10:5845163(-) A-I      intronic
chr10:5844480(-) A-I      intronic
chr10:5844462(-) A-I      intronic
chr10:5844394(-) A-I      intronic
chr10:5843912(-) A-I      intronic
chr10:5843802(-) A-I      intronic
chr10:5843110(-) A-I      intronic
chr10:5843093(-) A-I      intronic
chr10:5843086(-) A-I      intronic
chr10:5843079(-) A-I      intronic
chr10:5837879(-) A-I      intronic
chr10:5850530(-) A-I      intronic
chr10:5837842(-) A-I      intronic
chr10:5850204(-) A-I      intronic
chr10:5821823(-) A-I      intronic
chr10:5850134(-) A-I      intronic
chr10:5850205(-) A-I      intronic
chr10:5837713(-) A-I      intronic
chr10:5850206(-) A-I      intronic
chr10:5837281(-) A-I      intronic
chr10:5846990(-) A-I      intronic
chr10:5837254(-) A-I      intronic
chr10:5837244(-) A-I      intronic
chr10:5835154(-) A-I      intronic
chr10:5835090(-) A-I      intronic
chr10:5835030(-) A-I      intronic
chr10:5832602(-) A-I      intronic
chr10:5832563(-) A-I      intronic
chr10:5832532(-) A-I      intronic
chr10:5832527(-) A-I      intronic
chr10:5832509(-) A-I      intronic
chr10:5845304(-) A-I      intronic
chr10:5832444(-) A-I      intronic
chr10:5850266(-) A-I      intronic
chr10:5832435(-) A-I      intronic
chr10:5829359(-) A-I      intronic
chr10:5829358(-) A-I      intronic
chr10:5829355(-) A-I      intronic
chr10:5847024(-) A-I      intronic
chr10:5829345(-) A-I      intronic
chr10:5829343(-) A-I      intronic
chr10:5835204(-) A-I      intronic
chr10:5821748(-) A-I      intronic
chr10:5829305(-) A-I      intronic
chr10:5829250(-) A-I      intronic
chr10:5846160(-) A-I      intronic
chr10:5828402(-) A-I      intronic
chr10:5837885(-) A-I      intronic
chr10:5828316(-) A-I      intronic
chr10:5828313(-) A-I      intronic
chr10:5828312(-) A-I      intronic
chr10:5828310(-) A-I      intronic
chr10:5847000(-) A-I      intronic
chr10:5828298(-) A-I      intronic
chr10:5837809(-) A-I      intronic
chr10:5822170(-) A-I      intronic
chr10:5822057(-) A-I      intronic
chr10:5821850(-) A-I      intronic
chr10:5821830(-) A-I      intronic
chr10:5821825(-) A-I      intronic
chr10:5844479(-) A-I      intronic
chr10:5821802(-) A-I      intronic
chr10:5847628(-) A-I      intronic
chr10:5821981(-) A-I      intronic
chr10:5845292(-) A-I      intronic
chr10:5821388(-) A-I      intronic
chr10:5828201(-) A-I      intronic
chr10:5821888(-) A-I      intronic
chr10:5843825(-) A-I      intronic
chr10:5843052(-) A-I      intronic
chr10:5836051(-) A-I      intronic
chr10:5846236(-) A-I      intronic
chr10:5843815(-) A-I      intronic
chr10:5830257(-) A-I      intronic
chr10:5821824(-) A-I      intronic
chr10:5847068(-) A-I      intronic
chr10:5828367(-) A-I      intronic
chr10:5846094(-) A-I      intronic
chr10:5821859(-) A-I      intronic
chr10:5837200(-) A-I      intronic
chr10:5822090(-) A-I      intronic
chr10:5843197(-) A-I      intronic
chr10:5847465(-) A-I      intronic
chr10:5843382(-) A-I      intronic
chr10:5827475(-) A-I      intronic
chr10:5821820(-) A-I      intronic
chr10:5843826(-) A-I      intronic
chr10:5845263(-) A-I      intronic
chr10:5843874(-) A-I      intronic
chr10:5835040(-) A-I      intronic
chr10:5846195(-) A-I      intronic
chr10:5832486(-) A-I      intronic
chr10:5843053(-) A-I      intronic
chr10:5843552(-) A-I      intronic
chr10:5821838(-) A-I      intronic
chr10:5846294(-) A-I      intronic
chr10:5830890(-) A-I      intronic
chr10:5835106(-) A-I      intronic
chr10:5848354(-) A-I      intronic
chr10:5850117(-) A-I      intronic
chr10:5832487(-) A-I      intronic
chr10:5821314(-) A-I      intronic
chr10:5842989(-) A-I      intronic
chr10:5843095(-) A-I      intronic
chr10:5809353(-) A-I      intronic
chr10:5821872(-) A-I      intronic
chr10:5846346(-) A-I      intronic
chr10:5821754(-) A-I      intronic
chr10:5846998(-) A-I      intronic
chr10:5835130(-) A-I      intronic
chr10:5837843(-) A-I      intronic
chr10:5830222(-) A-I      intronic
chr10:5822158(-) A-I      intronic
chr10:5821929(-) A-I      intronic
chr10:5843852(-) A-I      intronic
chr10:5822141(-) A-I      intronic
chr10:5835131(-) A-I      intronic
chr10:5846250(-) A-I      intronic
chr10:5832570(-) A-I      intronic
chr10:5822048(-) A-I      intronic
chr10:5822060(-) A-I      intronic
chr10:5845219(-) A-I      intronic
chr10:5835190(-) A-I      intronic
chr10:5821740(-) A-I      intronic
chr10:5821794(-) A-I      intronic
chr10:5821869(-) A-I      intronic
chr10:5850049(-) A-I      intronic
chr10:5843523(-) A-I      intronic
chr10:5835964(-) A-I      intronic
chr10:5821438(-) A-I      intronic
chr10:5845381(-) A-I      intronic
chr10:5835050(-) A-I      intronic
chr10:5845213(-) A-I      intronic
chr10:5822091(-) A-I      intronic
chr10:5850188(-) A-I      intronic
chr10:5843038(-) A-I      intronic
chr10:5851086(-) A-I      intronic
chr10:5829423(-) A-I      intronic
chr10:5835177(-) A-I      intronic
chr10:5822015(-) A-I      intronic
chr10:5832427(-) A-I      intronic
chr10:5850079(-) A-I      intronic
chr10:5822050(-) A-I      intronic
chr10:5835046(-) A-I      intronic
chr10:5843909(-) A-I      intronic
chr10:5846935(-) A-I      intronic
chr10:5846129(-) A-I      intronic
chr10:5844450(-) A-I      intronic
chr10:5847504(-) A-I      intronic
chr10:5846239(-) A-I      intronic
chr10:5821864(-) A-I      intronic
chr10:5847547(-) A-I      intronic
chr10:5821717(-) A-I      intronic
chr10:5835157(-) A-I      intronic
chr10:5830909(-) A-I      intronic
chr10:5821907(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED GDI2
chr10:5821717(-) A-I intron -    22327324
chr10:5821717(-) A-G intron -    22484847
chr10:5821754(-) A-G intron -    22484847
chr10:5821864(-) A-G intron -    22484847
chr10:5845213(-) A-G intron -    22484847
chr10:5845304(-) A-G intron -    22484847
chr10:5846160(-) A-G intron -    22484847
chr10:5846256(-) G-A intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase GDI2
chr10:5807717-5807718(-) m6A 3'UTR//exon       26404942
chr10:5807747-5807748(-) m6A 3'UTR//exon       26404942
chr10:5807939-5807940(-) m6A 3'UTR//exon       24981863//26404942//22575960//22608085
chr10:5807972-5807973(-) m6A 3'UTR//CDS//exon       24981863//26404942//22575960//22608085
chr10:5808050-5808051(-) m6A CDS//exon       24981863//26404942//22575960
chr10:5808072-5808073(-) m6A CDS//exon       24981863//26404942//22575960
chr10:5808214-5808215(-) m6A CDS//exon       26404942
chr10:5808222-5808223(-) m6A CDS//exon       26404942
chr10:5810195-5810196(-) m6A CDS//exon       24981863
chr10:5810237-5810238(-) m6A CDS//exon       24981863
chr10:5810303-5810304(-) Am CDS//exon       -
chr10:5827193-5827194(-) m6A CDS       22575960
chr10:5827210-5827211(-) m6A CDS       22575960
chr10:5827821-5827822(-) m6A CDS       26404942//22575960
chr10:5827905-5827906(-) m6A CDS       22575960
chr10:5827932-5827933(-) m6A CDS       22575960
chr10:5838766-5838767(-) m6A CDS       26404942
chr10:5842606-5842607(-) m6A CDS//intron       26404942
chr10:5856245-5856246(-) m6A 5'UTR//intron       22608085
chr10:5884031-5884032(-) m6A 5'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-2-5p
Exosome B cell line (Raji)     21505438
GDI2
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: GDI2

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase//VIRmiRNA

References:


PMID 22291592 Target region CDS
Source ViRBase//VIRmiRNA Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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