Basic Information:

  VIRBase ID:  

VHID00279566

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-2-5p:  MIMAT0000996          BIRC3:  NM_182962     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-2-5p	BIRC3
miRBase Accession/Entrez ID	MIMAT0000996	330
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AIP1//API2//c-IAP2//CIAP2//HAIP1//HIAP1//IAP-1//MALT2//MIHC//RNF49

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BIRC3	chr11:102204095(+) A-I      intronic chr11:102202476(+) A-I      intronic chr11:102198286(+) A-I      intronic chr11:102207046(+) A-I      intronic chr11:102202455(+) A-I      intronic chr11:102202555(+) A-I      intronic chr11:102202524(+) A-I      intronic chr11:102204038(+) A-I      intronic chr11:102198310(+) A-I      intronic chr11:102204144(+) A-I      intronic chr11:102197579(+) A-I      intronic chr11:102197513(+) A-I      intronic chr11:102197519(+) A-I      intronic chr11:102204583(+) A-I      intronic chr11:102198219(+) A-I      intronic chr11:102202594(+) A-I      intronic chr11:102205710(+) A-I      intronic chr11:102205832(+) A-I      intronic chr11:102205853(+) A-I      intronic chr11:102205881(+) A-I      intronic chr11:102205893(+) A-I      intronic chr11:102206398(+) A-I      intronic chr11:102206448(+) A-I      intronic chr11:102206477(+) A-I      intronic chr11:102205887(+) A-I      intronic chr11:102205700(+) A-I      intronic chr11:102202511(+) A-I      intronic chr11:102205786(+) A-I      intronic chr11:102202572(+) A-I      intronic chr11:102205866(+) A-I      intronic chr11:102204112(+) A-I      intronic chr11:102202479(+) A-I      intronic chr11:102202446(+) A-I      intronic chr11:102204092(+) A-I      intronic chr11:102202633(+) A-I      intronic chr11:102204065(+) A-I      intronic chr11:102202407(+) A-I      intronic chr11:102204217(+) A-I      intronic chr11:102204240(+) A-I      intronic chr11:102204145(+) A-I      intronic chr11:102204397(+) A-I      intronic chr11:102198210(+) A-I      intronic chr11:102204069(+) A-I      intronic chr11:102202593(+) A-I      intronic chr11:102204603(+) A-I      intronic chr11:102197458(+) A-I      intronic chr11:102202606(+) A-I      intronic chr11:102202560(+) A-I      intronic chr11:102202445(+) A-I      intronic chr11:102197622(+) A-I      intronic chr11:102202437(+) A-I      intronic chr11:102204032(+) A-I      intronic chr11:102197542(+) A-I      intronic chr11:102206447(+) A-I      intronic chr11:102198192(+) A-I      intronic chr11:102202537(+) A-I      intronic chr11:102206474(+) A-I      intronic chr11:102204078(+) A-I      intronic chr11:102206397(+) A-I      intronic chr11:102197538(+) A-I      intronic chr11:102205826(+) A-I      intronic chr11:102192321(+) A-I      intronic chr11:102198224(+) A-I      intronic chr11:102207214(+) A-I      intronic chr11:102202634(+) A-I      intronic chr11:102204093(+) A-I      intronic chr11:102202456(+) A-I      intronic chr11:102204151(+) A-I      intronic chr11:102206473(+) A-I      intronic chr11:102198303(+) A-I      intronic chr11:102197601(+) A-I      intronic chr11:102204148(+) A-I      intronic chr11:102204212(+) A-I      intronic chr11:102202607(+) A-I      intronic chr11:102205701(+) A-I      intronic chr11:102204142(+) A-I      intronic chr11:102204398(+) A-I      intronic chr11:102202592(+) A-I      intronic chr11:102198200(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BIRC3	chr11:102204112(+) A-I intron -    22327324 chr11:102197542(+) A-G intron -    22484847 chr11:102202407(+) A-G intron -    22484847 chr11:102202572(+) A-G intron -    22484847 chr11:102202592(+) A-G intron -    22484847 chr11:102202607(+) A-G intron -    22484847 chr11:102204032(+) A-G intron -    22484847 chr11:102204065(+) A-G intron -    22484847 chr11:102204069(+) A-G intron -    22484847 chr11:102204092(+) A-G intron -    22484847 chr11:102204093(+) A-G intron -    22484847 chr11:102204112(+) A-G intron -    22484847 chr11:102204397(+) A-G intron -    22484847 chr11:102204398(+) A-G intron -    22484847 chr11:102204603(+) A-G intron -    22484847 chr11:102205866(+) A-G intron -    22484847 chr11:102206397(+) A-G intron -    22484847 chr11:102206473(+) A-G intron -    22484847 chr11:102206474(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BIRC3	chr11:102192629-102192630(+) m6A 5'UTR//exon//intron       26404942 chr11:102192645-102192646(+) m6A 5'UTR//exon//intron       26404942 chr11:102192664-102192665(+) m6A 5'UTR//exon//intron       26404942 chr11:102192704-102192705(+) m6A 5'UTR//exon//intron       26404942 chr11:102192757-102192758(+) m6A 5'UTR//exon//intron       26404942 chr11:102192972-102192973(+) m6A 5'UTR//exon//intron       26404942 chr11:102193010-102193011(+) m6A 5'UTR//intron       26404942 chr11:102193071-102193072(+) m6A 5'UTR//intron       26404942 chr11:102193267-102193268(+) m6A 5'UTR//intron       26404942 chr11:102193288-102193289(+) m6A 5'UTR//intron       26404942 chr11:102193433-102193434(+) m6A 5'UTR//intron       26404942 chr11:102193486-102193487(+) m6A 5'UTR//intron       26404942 chr11:102193843-102193844(+) m6A 5'UTR//intron       26404942 chr11:102193855-102193856(+) m6A 5'UTR//intron       26404942 chr11:102193925-102193926(+) m6A 5'UTR//intron       26404942 chr11:102194133-102194134(+) m6A 5'UTR//intron       26404942 chr11:102194175-102194176(+) m6A 5'UTR//intron       26404942 chr11:102194206-102194207(+) m6A 5'UTR//intron       26404942 chr11:102194220-102194221(+) m6A 5'UTR//intron       26404942 chr11:102194229-102194230(+) m6A 5'UTR//intron       26404942 chr11:102194757-102194758(+) m6A 5'UTR//intron       26404942 chr11:102194784-102194785(+) m6A 5'UTR//intron       26404942 chr11:102195189-102195190(+) m6A 5'UTR//intron       24209618//22575960 chr11:102195244-102195245(+) m6A CDS       24209618//24981863//22575960 chr11:102195256-102195257(+) m6A CDS       24209618//24981863//22575960 chr11:102195302-102195303(+) m6A CDS       24284625//24209618//24981863//22575960 chr11:102195326-102195327(+) m6A CDS       24284625//24209618//24981863//22575960 chr11:102195478-102195479(+) m6A CDS       24209618//24981863//26404942//22575960 chr11:102195628-102195629(+) m6A CDS       24284625//24209618//24981863//26404942//22575960 chr11:102195658-102195659(+) m6A CDS       24284625//24209618//24981863//26404942//22575960 chr11:102195679-102195680(+) m6A CDS       24284625//24209618//24981863//26404942//22575960 chr11:102195771-102195772(+) m6A CDS       24284625//24209618//24981863//26404942//22575960 chr11:102195833-102195834(+) m6A CDS       24284625//24209618//24981863//26404942//22575960 chr11:102195841-102195842(+) m6A CDS       24284625//24209618//24981863//26404942//22575960 chr11:102195887-102195888(+) m6A CDS       24284625//24209618//24981863//26404942//22575960 chr11:102195911-102195912(+) m6A CDS       24284625//24209618//24981863//26404942//22575960 chr11:102195920-102195921(+) m6A CDS       24284625//24209618//24981863//26404942//22575960 chr11:102195961-102195962(+) m6A CDS       24209618//24981863//26404942//22575960 chr11:102195999-102196000(+) m6A CDS       24209618//24981863//26404942//22575960 chr11:102196020-102196021(+) m6A CDS       24981863//26404942//22575960 chr11:102199643-102199644(+) m6A CDS       26404942 chr11:102201742-102201743(+) m6A CDS       26404942//22575960 chr11:102201753-102201754(+) m6A CDS       26404942//22575960 chr11:102201835-102201836(+) m6A CDS       24981863//26404942//27773535//22575960 chr11:102201880-102201881(+) m6A CDS       24284625//24981863//26404942//27773535//22575960 chr11:102201903-102201904(+) m6A CDS       24284625//24981863//26404942//27773535//22575960 chr11:102206799-102206800(+) m6A CDS       24981863//26404942//27773535 chr11:102206805-102206806(+) m6A CDS       24981863//26404942//27773535 chr11:102206820-102206821(+) m6A CDS       24981863//26404942//27773535 chr11:102206827-102206828(+) m6A CDS       24981863//26404942//27773535 chr11:102206853-102206854(+) m6A CDS       24981863//26404942 chr11:102206906-102206907(+) m6A CDS       24981863//26404942 chr11:102207499-102207500(+) m6A CDS//exon       26404942 chr11:102207655-102207656(+) m6A CDS//exon       26404942 chr11:102207667-102207668(+) m6A CDS//exon       26404942 chr11:102207683-102207684(+) m6A CDS//exon       26404942 chr11:102207702-102207703(+) m6A CDS//exon       26404942 chr11:102207984-102207985(+) m6A 3'UTR//exon       26404942 chr11:102207993-102207994(+) m6A 3'UTR//exon       26404942 chr11:102208010-102208011(+) m6A 3'UTR//exon       26404942 chr11:102208065-102208066(+) m6A 3'UTR       26404942 chr11:102208117-102208118(+) m6A 3'UTR       26404942 chr11:102208181-102208182(+) m6A 3'UTR       26404942 chr11:102208282-102208283(+) m6A 3'UTR       26404942 chr11:102208297-102208298(+) m6A 3'UTR       26404942 chr11:102208306-102208307(+) m6A 3'UTR       26404942 chr11:102208312-102208313(+) m6A 3'UTR       26404942 chr11:102208317-102208318(+) m6A 3'UTR       26404942 chr11:102208326-102208327(+) m6A 3'UTR       26404942 chr11:102208552-102208553(+) m6A 3'UTR       26404942 chr11:102208604-102208605(+) m6A 3'UTR       26404942 chr11:102208648-102208649(+) m6A 3'UTR       26404942 chr11:102208659-102208660(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-2-5p	Exosome B cell line (Raji)     21505438
	BIRC3	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-2-5p
Interactor2: BIRC3

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).