Detail Information

Basic Information:


  VIRBase ID:  

VHID00279311

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:           MCM9:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-1 MCM9
miRBase
Accession/Entrez ID		 MIMAT0000995 254394
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - C6orf61//dJ329L24.1//dJ329L24.3//MCMDC1//ODG4

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MCM9
chr6:119159537(-) A-I      intronic
chr6:119159543(-) A-I      intronic
chr6:119159563(-) A-I      intronic
chr6:119169975(-) A-I      intronic
chr6:119170009(-) A-I      intronic
chr6:119174746(-) A-I      intronic
chr6:119163955(-) A-I      intronic
chr6:119163263(-) A-I      intronic
chr6:119189246(-) A-I      intronic
chr6:119163074(-) A-I      intronic
chr6:119163954(-) A-I      intronic
chr6:119163949(-) A-I      intronic
chr6:119163902(-) A-I      intronic
chr6:119163895(-) A-I      intronic
chr6:119163882(-) A-I      intronic
chr6:119163881(-) A-I      intronic
chr6:119163961(-) A-I      intronic
chr6:119164533(-) A-I      intronic
chr6:119244587(-) A-I      intronic
chr6:119244570(-) A-I      intronic
chr6:119207925(-) A-I      intronic
chr6:119189329(-) A-I      intronic
chr6:119189321(-) A-I      intronic
chr6:119189319(-) A-I      intronic
chr6:119189312(-) A-I      intronic
chr6:119189218(-) A-I      intronic
chr6:119189134(-) A-I      intronic
chr6:119175748(-) A-I      intronic
chr6:119175670(-) A-I      intronic
chr6:119175654(-) A-I      intronic
chr6:119175653(-) A-I      intronic
chr6:119175645(-) A-I      intronic
chr6:119163850(-) A-I      intronic
chr6:119175621(-) A-I      intronic
chr6:119174929(-) A-I      intronic
chr6:119169965(-) A-I      intronic
chr6:119164535(-) A-I      intronic
chr6:119164557(-) A-I      intronic
chr6:119164651(-) A-I      intronic
chr6:119164728(-) A-I      intronic
chr6:119169924(-) A-I      intronic
chr6:119169963(-) A-I      intronic
chr6:119135133(-) A-I      3'UTR
chr6:119135119(-) A-I      3'UTR
chr6:119135117(-) A-I      3'UTR
chr6:119135172(-) A-I      3'UTR
chr6:119135155(-) A-I      3'UTR
chr6:119135149(-) A-I      3'UTR
chr6:119135135(-) A-I      3'UTR
chr6:119175717(-) A-I      intronic
chr6:119249404(-) A-I      intronic
chr6:119189313(-) A-I      intronic
chr6:119237307(-) A-I      intronic
chr6:119174905(-) A-I      intronic
chr6:119175662(-) A-I      intronic
chr6:119249320(-) A-I      intronic
chr6:119164705(-) A-I      intronic
chr6:119174795(-) A-I      intronic
chr6:119189206(-) A-I      intronic
chr6:119231200(-) A-I      intronic
chr6:119189180(-) A-I      intronic
chr6:119153498(-) A-I      intronic
chr6:119159581(-) A-I      intronic
chr6:119169836(-) A-I      intronic
chr6:119174931(-) A-I      intronic
chr6:119174745(-) A-I      intronic
chr6:119159557(-) A-I      intronic
chr6:119249393(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MCM9
chr6:119150412(-) C-T exon CDS    21725310
chr6:119175816(-) A-G intron -    22484847
chr6:119164705(-) A-G intron -    22484847
chr6:119170078(-) A-G intron -    22484847
chr6:119174744(-) A-G intron -    22484847
chr6:119174745(-) A-G intron -    22484847
chr6:119174905(-) A-G intron -    22484847
chr6:119174910(-) A-G intron -    22484847
chr6:119174931(-) A-G intron -    22484847
chr6:119175662(-) A-G intron -    22484847
chr6:119175664(-) A-G intron -    22484847
chr6:119175717(-) A-G intron -    22484847
chr6:119175780(-) A-G intron -    22484847
chr6:119175789(-) A-G intron -    22484847
chr6:119231200(-) A-G intron -    22484847
chr6:119249393(-) A-G intron -    22484847
chr6:119249404(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MCM9
chr6:119134746-119134747(-) m6A 3'UTR       24981863
chr6:119134762-119134763(-) m6A 3'UTR       24981863
chr6:119134770-119134771(-) m6A 3'UTR       24981863
chr6:119135897-119135898(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr6:119135936-119135937(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:119136043-119136044(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:119136082-119136083(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:119136179-119136180(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr6:119136239-119136240(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr6:119136311-119136312(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960
chr6:119136342-119136343(-) m6A CDS       24209618//25456834//24981863//27773535//27371828
chr6:119136412-119136413(-) m6A CDS       24209618//25456834//24981863//27773535//27371828
chr6:119136418-119136419(-) m6A CDS       24209618//25456834//24981863//27773535//27371828
chr6:119136450-119136451(-) m6A CDS       25456834//24981863//27773535//27371828
chr6:119136479-119136480(-) m6A CDS       24981863//27773535//27371828
chr6:119136540-119136541(-) m6A CDS       24981863//27773535
chr6:119136628-119136629(-) m6A CDS       24981863//27773535//22608085
chr6:119136661-119136662(-) m6A CDS       24284625//24981863//27773535//22608085
chr6:119136733-119136734(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr6:119136752-119136753(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr6:119136764-119136765(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22575960//22608085
chr6:119136878-119136879(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr6:119136908-119136909(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr6:119136913-119136914(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr6:119136980-119136981(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr6:119137002-119137003(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr6:119137031-119137032(-) m6A CDS       24284625//25456834//24981863//27773535//22608085
chr6:119137119-119137120(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr6:119137148-119137149(-) m6A CDS       24284625//25456834//24981863//27773535//27371828//22608085
chr6:119137156-119137157(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr6:119137231-119137232(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr6:119137353-119137354(-) m6A CDS       24284625//24981863//27773535
chr6:119137361-119137362(-) m6A CDS       24981863//27773535
chr6:119137404-119137405(-) m6A CDS       24981863//27773535
chr6:119147317-119147318(-) m6A CDS       27773535
chr6:119215194-119215195(-) m6A exon//intron       -
chr6:119215207-119215208(-) m6A exon//intron       -
chr6:119215244-119215245(-) m6A exon//intron       24981863
chr6:119215252-119215253(-) m6A exon//intron       24284625//24981863
chr6:119215377-119215378(-) m6A exon//intron       24284625//24209618//24981863//22608085
chr6:119215444-119215445(-) m6A exon//intron       24284625//24209618//24981863//22575960//22608085
chr6:119215492-119215493(-) m6A exon//intron       24284625//24209618//24981863//27773535//22608085
chr6:119231889-119231890(-) m6A 3'UTR//exon//intron       27773535
chr6:119231977-119231978(-) m6A 3'UTR//exon//intron       27773535
chr6:119245199-119245200(-) m6A CDS//exon       24981863//22608085
chr6:119245211-119245212(-) m6A CDS//exon       24981863//22608085
chr6:119245233-119245234(-) m6A CDS       24981863//22608085
chr6:119245247-119245248(-) m6A CDS       24981863//22608085
chr6:119245260-119245261(-) m6A CDS       24981863//22608085
chr6:119252609-119252610(-) m6A CDS       22608085
chr6:119256131-119256132(-) m6A 5'UTR       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-1
Exosome Jurkat-derived T cell line (J77cl20)     21505438
MCM9
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-1
Interactor2: MCM9

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//RNAHybrid//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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