Basic Information:

  VIRBase ID:  

VHID00279083

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          UHMK1:  NM_144624     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	UHMK1
miRBase Accession/Entrez ID	MIMAT0000995	127933
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	KIS//KIST//P-CIP2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UHMK1	chr1:162471160(+) A-I      intronic chr1:162482992(+) A-I      intronic chr1:162486903(+) A-I      intronic chr1:162486968(+) A-I      intronic chr1:162486913(+) A-I      intronic chr1:162471101(+) A-I      intronic chr1:162482871(+) A-I      intronic chr1:162482928(+) A-I      intronic chr1:162482982(+) A-I      intronic chr1:162476963(+) A-I      intronic chr1:162476534(+) A-I      intronic chr1:162488700(+) A-I      intronic chr1:162489710(+) A-I      intronic chr1:162477937(+) A-I      intronic chr1:162489720(+) A-I      intronic chr1:162476488(+) A-I      intronic chr1:162489775(+) A-I      intronic chr1:162489892(+) A-I      intronic chr1:162489782(+) A-I      intronic chr1:162471687(+) A-I      intronic chr1:162471046(+) A-I      intronic chr1:162471023(+) A-I      intronic chr1:162486817(+) A-I      intronic chr1:162473333(+) A-I      intronic chr1:162491488(+) A-I      intronic chr1:162477558(+) A-I      intronic chr1:162489918(+) A-I      intronic chr1:162477489(+) A-I      intronic chr1:162491519(+) A-I      intronic chr1:162477567(+) A-I      intronic chr1:162473286(+) A-I      intronic chr1:162477049(+) A-I      intronic chr1:162476990(+) A-I      intronic chr1:162477929(+) A-I      intronic chr1:162473191(+) A-I      intronic chr1:162489806(+) A-I      intronic chr1:162487528(+) A-I      intronic chr1:162487070(+) A-I      intronic chr1:162473280(+) A-I      intronic chr1:162473238(+) A-I      intronic chr1:162488316(+) A-I      intronic chr1:162489712(+) A-I      intronic chr1:162489788(+) A-I      intronic chr1:162489869(+) A-I      intronic chr1:162477931(+) A-I      intronic chr1:162478645(+) A-I      intronic chr1:162478269(+) A-I      intronic chr1:162481146(+) A-I      intronic chr1:162488351(+) A-I      intronic chr1:162482857(+) A-I      intronic chr1:162489758(+) A-I      intronic chr1:162478371(+) A-I      intronic chr1:162478261(+) A-I      intronic chr1:162483004(+) A-I      intronic chr1:162489001(+) A-I      intronic chr1:162476532(+) A-I      intronic chr1:162476466(+) A-I      intronic chr1:162482812(+) A-I      intronic chr1:162488987(+) A-I      intronic chr1:162483956(+) A-I      intronic chr1:162489831(+) A-I      intronic chr1:162478124(+) A-I      intronic chr1:162471024(+) A-I      intronic chr1:162476604(+) A-I      intronic chr1:162487075(+) A-I      intronic chr1:162486929(+) A-I      intronic chr1:162478479(+) A-I      intronic chr1:162473278(+) A-I      intronic chr1:162482849(+) A-I      intronic chr1:162489825(+) A-I      intronic chr1:162478232(+) A-I      intronic chr1:162482977(+) A-I      intronic chr1:162478041(+) A-I      intronic chr1:162473142(+) A-I      intronic chr1:162482773(+) A-I      intronic chr1:162477930(+) A-I      intronic chr1:162485639(+) A-I      intronic chr1:162476467(+) A-I      intronic chr1:162488985(+) A-I      intronic chr1:162473218(+) A-I      intronic chr1:162487030(+) A-I      intronic chr1:162491334(+) A-I      intronic chr1:162473144(+) A-I      intronic chr1:162486966(+) A-I      intronic chr1:162477583(+) A-I      intronic chr1:162486942(+) A-I      intronic chr1:162489815(+) A-I      intronic chr1:162491322(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UHMK1	chr1:162471024(+) A-G intron -    22484847 chr1:162473278(+) A-G intron -    22484847 chr1:162476466(+) A-G intron -    22484847 chr1:162476467(+) A-G intron -    22484847 chr1:162476532(+) A-G intron -    22484847 chr1:162477583(+) A-G intron -    22484847 chr1:162477930(+) A-G intron -    22484847 chr1:162477931(+) A-G intron -    22484847 chr1:162481146(+) A-G intron -    22484847 chr1:162481147(+) G-A intron -    22484847 chr1:162482773(+) A-G intron -    22484847 chr1:162482849(+) A-G intron -    22484847 chr1:162482857(+) A-G intron -    22484847 chr1:162483004(+) A-G intron -    22484847 chr1:162485639(+) A-G intron -    22484847 chr1:162486966(+) A-G intron -    22484847 chr1:162487030(+) A-G intron -    22484847 chr1:162487075(+) A-G intron -    22484847 chr1:162488351(+) A-G intron -    22484847 chr1:162489712(+) A-G intron -    22484847 chr1:162489788(+) A-G intron -    22484847 chr1:162489831(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UHMK1	chr1:162469955-162469956(+) m6A CDS//exon       - chr1:162469997-162469998(+) m6A CDS//exon       - chr1:162470012-162470013(+) m6A CDS//exon       - chr1:162487931-162487932(+) m6A CDS//exon//intron       22575960 chr1:162487976-162487977(+) m6A CDS//exon//intron       22575960 chr1:162492328-162492329(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr1:162492354-162492355(+) m6A 3'UTR//exon       24284625//24981863 chr1:162492410-162492411(+) m6A 3'UTR//exon       24284625//24981863 chr1:162493551-162493552(+) m6A 3'UTR//exon       24981863 chr1:162493635-162493636(+) Tm 3'UTR//exon       - chr1:162493650-162493651(+) m6A 3'UTR//exon       24981863 chr1:162495183-162495184(+) Y 3'UTR       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	UHMK1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: UHMK1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).