Basic Information:

  VIRBase ID:  

VHID00278941

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          NAV2:  NM_145117     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	NAV2
miRBase Accession/Entrez ID	MIMAT0000995	89797
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HELAD1//POMFIL2//RAINB1//STEERIN2//UNC53H2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NAV2	chr11:20130052(+) A-I      intronic chr11:20105747(+) A-I      intronic chr11:19783669(+) A-I      intronic chr11:19784432(+) A-I      intronic chr11:19941430(+) A-I      intronic chr11:19941451(+) A-I      intronic chr11:19941465(+) A-I      intronic chr11:19941484(+) A-I      intronic chr11:19784426(+) A-I      intronic chr11:19783674(+) A-I      intronic chr11:19941498(+) A-I      intronic chr11:19941499(+) A-I      intronic chr11:19941510(+) A-I      intronic chr11:19941525(+) A-I      intronic chr11:19941526(+) A-I      intronic chr11:19941424(+) A-I      intronic chr11:19941416(+) A-I      intronic chr11:19632540(+) A-I      intronic chr11:19632539(+) A-I      intronic chr11:19632538(+) A-I      intronic chr11:19632516(+) A-I      intronic chr11:20135354(+) A-I      intronic chr11:20027541(+) A-I      intronic chr11:20027542(+) A-I      intronic chr11:20028261(+) A-I      intronic chr11:20028277(+) A-I      intronic chr11:19808477(+) A-I      intronic chr11:20028292(+) A-I      intronic chr11:20028318(+) A-I      intronic chr11:20028596(+) A-I      intronic chr11:20028642(+) A-I      intronic chr11:20039779(+) A-I      intronic chr11:20105761(+) A-I      intronic chr11:20105773(+) A-I      intronic chr11:20105827(+) A-I      intronic chr11:20127999(+) A-I      intronic chr11:20128282(+) A-I      intronic chr11:20130092(+) A-I      intronic chr11:20130278(+) A-I      intronic chr11:20015829(+) A-I      intronic chr11:19879544(+) A-I      intronic chr11:19879601(+) A-I      intronic chr11:19879587(+) A-I      intronic chr11:19991336(+) A-I      intronic chr11:19731321(+) A-I      intronic chr11:20028769(+) A-I      intronic chr11:20027589(+) A-I      intronic chr11:19879609(+) A-I      intronic chr11:19879548(+) A-I      intronic chr11:20128375(+) A-I      intronic chr11:20135520(+) A-I      intronic chr11:20135293(+) A-I      intronic chr11:19953935(+) A-I      intronic chr11:19879584(+) A-I      intronic chr11:19879528(+) A-I      intronic chr11:19879568(+) A-I      intronic chr11:19879569(+) A-I      intronic chr11:19879613(+) A-I      intronic chr11:20106502(+) A-I      intronic chr11:19879645(+) A-I      intronic chr11:19879589(+) A-I      intronic chr11:19879555(+) A-I      intronic chr11:19879520(+) A-I      intronic chr11:19879542(+) A-I      intronic chr11:20028385(+) A-I      intronic chr11:19958573(+) A-I      intronic chr11:20135512(+) A-I      intronic chr11:19624971(+) A-I      intronic chr11:19965543(+) A-I      intronic chr11:19808660(+) A-I      intronic chr11:19587839(+) A-I      intronic chr11:19648743(+) A-I      intronic chr11:20015973(+) A-I      intronic chr11:19652342(+) A-I      intronic chr11:19808548(+) A-I      intronic chr11:19808914(+) A-I      intronic chr11:19808936(+) A-I      intronic chr11:19814644(+) A-I      intronic chr11:19814648(+) A-I      intronic chr11:19846592(+) A-I      intronic chr11:19846744(+) A-I      intronic chr11:19849437(+) A-I      intronic chr11:19896532(+) A-I      intronic chr11:19916699(+) A-I      intronic chr11:19941402(+) A-I      intronic chr11:20135348(+) A-I      intronic chr11:19942035(+) A-I      intronic chr11:19942040(+) A-I      intronic chr11:19957683(+) A-I      intronic chr11:19958422(+) A-I      intronic chr11:19958427(+) A-I      intronic chr11:19976918(+) A-I      intronic chr11:19991234(+) A-I      intronic chr11:19991345(+) A-I      intronic chr11:19991361(+) A-I      intronic chr11:19991371(+) A-I      intronic chr11:19991381(+) A-I      intronic chr11:19991989(+) A-I      intronic chr11:20007226(+) A-I      intronic chr11:19941914(+) A-I      intronic chr11:20007331(+) A-I      intronic chr11:20007916(+) A-I      intronic chr11:20008098(+) A-I      intronic chr11:20014273(+) A-I      intronic chr11:20014349(+) A-I      intronic chr11:19625021(+) A-I      intronic chr11:19917997(+) A-I      intronic chr11:19808722(+) A-I      intronic chr11:19860282(+) A-I      intronic chr11:19652232(+) A-I      intronic chr11:19896580(+) A-I      intronic chr11:19958605(+) A-I      intronic chr11:19850092(+) A-I      intronic chr11:19652324(+) A-I      intronic chr11:19965461(+) A-I      intronic chr11:19896582(+) A-I      intronic chr11:19760741(+) A-I      intronic chr11:19562323(+) A-I      intronic chr11:19814635(+) A-I      intronic chr11:20106526(+) A-I      intronic chr11:20007162(+) A-I      intronic chr11:19732107(+) A-I      intronic chr11:20036165(+) A-I      intronic chr11:19732109(+) A-I      intronic chr11:19808472(+) A-I      intronic chr11:19966977(+) A-I      intronic chr11:20128894(+) A-I      intronic chr11:19958464(+) A-I      intronic chr11:19808766(+) A-I      intronic chr11:20028283(+) A-I      intronic chr11:19953905(+) A-I      intronic chr11:19991840(+) A-I      intronic chr11:20039821(+) A-I      intronic chr11:19957440(+) A-I      intronic chr11:19784343(+) A-I      intronic chr11:20129111(+) A-I      intronic chr11:20106479(+) A-I      intronic chr11:19783710(+) A-I      intronic chr11:19846788(+) A-I      intronic chr11:19475921(+) A-I      intronic chr11:19652231(+) A-I      intronic chr11:20130032(+) A-I      intronic chr11:20028763(+) A-I      intronic chr11:20129127(+) A-I      intronic chr11:20039820(+) A-I      intronic chr11:19860274(+) A-I      intronic chr11:19846673(+) A-I      intronic chr11:19625062(+) A-I      intronic chr11:19942107(+) A-I      intronic chr11:19808776(+) A-I      intronic chr11:19965530(+) A-I      intronic chr11:19967126(+) A-I      intronic chr11:19808402(+) A-I      intronic chr11:20014413(+) A-I      intronic chr11:20014401(+) A-I      intronic chr11:19850147(+) A-I      intronic chr11:19991898(+) A-I      intronic chr11:19941934(+) A-I      intronic chr11:19966984(+) A-I      intronic chr11:20105854(+) A-I      intronic chr11:20135297(+) A-I      intronic chr11:19965524(+) A-I      intronic chr11:19896553(+) A-I      intronic chr11:20029879(+) A-I      intronic chr11:19983611(+) A-I      intronic chr11:19991889(+) A-I      intronic chr11:19475922(+) A-I      intronic chr11:20106056(+) A-I      intronic chr11:19919314(+) A-I      intronic chr11:19587685(+) A-I      intronic chr11:19625094(+) A-I      intronic chr11:20014329(+) A-I      intronic chr11:20027576(+) A-I      intronic chr11:20130237(+) A-I      intronic chr11:19497707(+) A-I      intronic chr11:19922837(+) A-I      intronic chr11:19808717(+) A-I      intronic chr11:20028255(+) A-I      intronic chr11:19846561(+) A-I      intronic chr11:19996149(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NAV2	chr11:19879520(+) A-I intron -    22028664 chr11:19879528(+) A-I intron -    22028664 chr11:19879542(+) A-I intron -    22028664 chr11:19879544(+) A-I intron -    22028664 chr11:19879548(+) A-I intron -    22028664 chr11:19879555(+) A-I intron -    22028664 chr11:19879568(+) A-I intron -    22028664 chr11:19879569(+) A-I intron -    22028664 chr11:19879584(+) A-I intron -    22028664 chr11:19879587(+) A-I intron -    22028664 chr11:19879589(+) A-I intron -    22028664 chr11:19879601(+) A-I intron -    22028664 chr11:19879609(+) A-I intron -    22028664 chr11:19879613(+) A-I intron -    22028664 chr11:19879645(+) A-I intron -    22028664 chr11:19470899(+) C-T intron -    22484847 chr11:19470930(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NAV2	chr11:19372348-19372349(+) m6A 5'UTR       - chr11:19372356-19372357(+) m6A 5'UTR       - chr11:19372396-19372397(+) m6A 5'UTR       - chr11:19735013-19735014(+) m6A 5'UTR//intron       25456834 chr11:19799038-19799039(+) m6A intron       24209618 chr11:19799415-19799416(+) m6A exon//intron       - chr11:19905853-19905854(+) m6A CDS//intron       24284625 chr11:19914028-19914029(+) m6A CDS       24284625 chr11:19914096-19914097(+) m6A CDS       24284625//24981863 chr11:19955007-19955008(+) m6A CDS//exon       24284625//25456834//24981863//22575960 chr11:19955060-19955061(+) m6A CDS//exon       24284625//25456834//24981863//22575960 chr11:19955083-19955084(+) m6A CDS//exon       24284625//25456834//24981863//22575960 chr11:19955197-19955198(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960 chr11:19955262-19955263(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960 chr11:19955297-19955298(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr11:19955333-19955334(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr11:19955357-19955358(+) m6A CDS       24284625//24209618//25456834//24981863//22575960 chr11:19955487-19955488(+) m6A CDS       24284625//25456834//24981863//22575960 chr11:19955580-19955581(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:19955613-19955614(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:19955668-19955669(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:19955678-19955679(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:19955698-19955699(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:19955719-19955720(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:19955728-19955729(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr11:19961217-19961218(+) m6A CDS       24284625 chr11:19970598-19970599(+) m6A CDS       24284625 chr11:19970606-19970607(+) m6A CDS       24284625 chr11:20005688-20005689(+) m6A CDS       24284625 chr11:20005714-20005715(+) m6A CDS       24284625 chr11:20005749-20005750(+) m6A CDS       24284625 chr11:20044584-20044585(+) m6A 5'UTR//intron       - chr11:20044668-20044669(+) m6A CDS//intron       - chr11:20048867-20048868(+) m6A exon//intron       - chr11:20049213-20049214(+) m6A exon//intron       - chr11:20057551-20057552(+) m6A CDS//exon       - chr11:20065608-20065609(+) m6A CDS//exon       24284625 chr11:20065718-20065719(+) m6A CDS//exon       24284625 chr11:20065805-20065806(+) m6A CDS//exon       24284625 chr11:20065814-20065815(+) m6A CDS//exon       24284625 chr11:20066518-20066519(+) m6A CDS//exon       24284625 chr11:20066647-20066648(+) m6A CDS       24284625//25456834//24981863 chr11:20066869-20066870(+) m6A CDS       24284625//25456834//24981863//22575960 chr11:20066933-20066934(+) m6A CDS       24284625//25456834//24981863//22575960 chr11:20067000-20067001(+) m6A CDS       24284625//25456834//24981863//22575960 chr11:20067019-20067020(+) m6A CDS       24284625//25456834//24981863//22575960 chr11:20067058-20067059(+) m6A CDS       24284625 chr11:20070386-20070387(+) m6A CDS       24284625//24981863 chr11:20070452-20070453(+) m6A CDS       24284625 chr11:20070709-20070710(+) m6A CDS       24284625 chr11:20070724-20070725(+) m6A CDS       24284625 chr11:20071438-20071439(+) m6A CDS//intron       24284625 chr11:20071443-20071444(+) m6A CDS//intron       24284625 chr11:20072854-20072855(+) m6A CDS//intron       24284625 chr11:20072873-20072874(+) m6A CDS//intron       24284625 chr11:20122701-20122702(+) m6A CDS       - chr11:20124849-20124850(+) m6A CDS       - chr11:20124861-20124862(+) m6A CDS       - chr11:20124885-20124886(+) m6A CDS       - chr11:20125221-20125222(+) m6A CDS       - chr11:20139682-20139683(+) m6A CDS//exon       24284625 chr11:20139778-20139779(+) m6A CDS//exon       24284625//24209618//24981863 chr11:20139923-20139924(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr11:20139931-20139932(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960 chr11:20139988-20139989(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:20140010-20140011(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr11:20140072-20140073(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:20140125-20140126(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:20140148-20140149(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:20140167-20140168(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:20140172-20140173(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:20140200-20140201(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:20140209-20140210(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:20140227-20140228(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:20140259-20140260(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr11:20140268-20140269(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr11:20140322-20140323(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr11:20140388-20140389(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr11:20140405-20140406(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr11:20140472-20140473(+) m6A 3'UTR       24284625 chr11:20140914-20140915(+) m6A 3'UTR       24284625//24209618//24981863 chr11:20140945-20140946(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr11:20140980-20140981(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr11:20141048-20141049(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr11:20141066-20141067(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr11:20141262-20141263(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr11:20141299-20141300(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr11:20141332-20141333(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr11:20141426-20141427(+) m6A 3'UTR       24284625//24209618//25456834//24981863 chr11:20141505-20141506(+) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	NAV2	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: NAV2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	CDS
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).