Detail Information

Basic Information:


  VIRBase ID:  

VHID00278745

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8925

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:           ARMT1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-1 ARMT1
miRBase
Accession/Entrez ID		 MIMAT0000995 79624
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - C6orf211

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ARMT1
chr6:151782567(+) A-I      intronic
chr6:151782630(+) A-I      intronic
chr6:151787315(+) A-I      intronic
chr6:151787314(+) A-I      intronic
chr6:151782672(+) A-I      intronic
chr6:151787123(+) A-I      intronic
chr6:151787211(+) A-I      intronic
chr6:151787283(+) A-I      intronic
chr6:151781315(+) A-I      intronic
chr6:151788461(+) A-I      intronic
chr6:151787154(+) A-I      intronic
chr6:151787193(+) A-I      intronic
chr6:151787288(+) A-I      intronic
chr6:151781659(+) A-I      intronic
chr6:151781804(+) A-I      intronic
chr6:151781665(+) A-I      intronic
chr6:151788289(+) A-I      intronic
chr6:151781798(+) A-I      intronic
chr6:151782685(+) A-I      intronic
chr6:151781735(+) A-I      intronic
chr6:151781710(+) A-I      intronic
chr6:151781666(+) A-I      intronic
chr6:151781360(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ARMT1
chr6:151773645-151773646(+) m6A 5'UTR       24981863
chr6:151773709-151773710(+) m6A 5'UTR//CDS//exon       24981863
chr6:151775708-151775709(+) m6A CDS//exon//intron       24981863
chr6:151775778-151775779(+) m6A CDS//exon//intron       24981863
chr6:151779525-151779526(+) m6A 5'UTR//CDS//exon       24981863
chr6:151789737-151789738(+) m6A CDS       27773535
chr6:151789768-151789769(+) m6A CDS       27773535
chr6:151789824-151789825(+) m6A CDS       27773535
chr6:151789833-151789834(+) m6A CDS       27773535
chr6:151791168-151791169(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-1
Exosome Jurkat-derived T cell line (J77cl20)     21505438
ARMT1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-1
Interactor2: ARMT1

Evidence Support:


Strong-Evidence Luciferase reporter assay
Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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