Basic Information:

  VIRBase ID:  

VHID00278519

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          TRERF1:  NM_001297573     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	TRERF1
miRBase Accession/Entrez ID	MIMAT0000995	55809
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BCAR2//dJ139D8.5//HSA277276//RAPA//TReP-132//TREP132

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TRERF1	chr6:42390710(-) A-I      intronic chr6:42376853(-) A-I      intronic chr6:42376791(-) A-I      intronic chr6:42352832(-) A-I      intronic chr6:42325053(-) A-I      intronic chr6:42324887(-) A-I      intronic chr6:42324493(-) A-I      intronic chr6:42319756(-) A-I      intronic chr6:42297615(-) A-I      intronic chr6:42390742(-) A-I      intronic chr6:42404044(-) A-I      intronic chr6:42296036(-) A-I      intronic chr6:42296020(-) A-I      intronic chr6:42295989(-) A-I      intronic chr6:42295914(-) A-I      intronic chr6:42295897(-) A-I      intronic chr6:42295884(-) A-I      intronic chr6:42295849(-) A-I      intronic chr6:42295812(-) A-I      intronic chr6:42295811(-) A-I      intronic chr6:42285835(-) A-I      intronic chr6:42285792(-) A-I      intronic chr6:42285748(-) A-I      intronic chr6:42266596(-) A-I      intronic chr6:42266595(-) A-I      intronic chr6:42266592(-) A-I      intronic chr6:42266578(-) A-I      intronic chr6:42266554(-) A-I      intronic chr6:42266475(-) A-I      intronic chr6:42209427(-) A-I      intronic chr6:42209733(-) A-I      intronic chr6:42209738(-) A-I      intronic chr6:42209747(-) A-I      intronic chr6:42209750(-) A-I      intronic chr6:42209765(-) A-I      intronic chr6:42324985(-) A-I      intronic chr6:42325004(-) A-I      intronic chr6:42413816(-) A-I      intronic chr6:42266474(-) A-I      intronic chr6:42266433(-) A-I      intronic chr6:42235356(-) A-I      intronic chr6:42235307(-) A-I      intronic chr6:42235267(-) A-I      intronic chr6:42235255(-) A-I      intronic chr6:42235245(-) A-I      intronic chr6:42235186(-) A-I      intronic chr6:42235183(-) A-I      intronic chr6:42235039(-) A-I      intronic chr6:42234988(-) A-I      intronic chr6:42234880(-) A-I      intronic chr6:42234164(-) A-I      intronic chr6:42212119(-) A-I      intronic chr6:42212098(-) A-I      intronic chr6:42209615(-) A-I      intronic chr6:42209751(-) A-I      intronic chr6:42209771(-) A-I      intronic chr6:42209773(-) A-I      intronic chr6:42209781(-) A-I      intronic chr6:42234962(-) A-I      intronic chr6:42234989(-) A-I      intronic chr6:42295940(-) A-I      intronic chr6:42295946(-) A-I      intronic chr6:42295950(-) A-I      intronic chr6:42295960(-) A-I      intronic chr6:42295966(-) A-I      intronic chr6:42413854(-) A-I      intronic chr6:42413855(-) A-I      intronic chr6:42413856(-) A-I      intronic chr6:42404047(-) A-I      intronic chr6:42413774(-) A-I      intronic chr6:42413785(-) A-I      intronic chr6:42389380(-) A-I      intronic chr6:42381438(-) A-I      intronic chr6:42380428(-) A-I      intronic chr6:42377022(-) A-I      intronic chr6:42389847(-) A-I      intronic chr6:42389866(-) A-I      intronic chr6:42389879(-) A-I      intronic chr6:42319867(-) A-I      intronic chr6:42234065(-) A-I      intronic chr6:42234818(-) A-I      intronic chr6:42413901(-) A-I      intronic chr6:42266076(-) A-I      intronic chr6:42412895(-) A-I      intronic chr6:42389787(-) A-I      intronic chr6:42380445(-) A-I      intronic chr6:42320877(-) A-I      intronic chr6:42293355(-) A-I      intronic chr6:42293368(-) A-I      intronic chr6:42405768(-) A-I      intronic chr6:42376254(-) A-I      intronic chr6:42287777(-) A-I      intronic chr6:42413890(-) A-I      intronic chr6:42327350(-) A-I      intronic chr6:42405842(-) A-I      intronic chr6:42405798(-) A-I      intronic chr6:42376970(-) A-I      intronic chr6:42293415(-) A-I      intronic chr6:42265996(-) A-I      intronic chr6:42266067(-) A-I      intronic chr6:42234024(-) A-I      intronic chr6:42209433(-) A-I      intronic chr6:42354178(-) A-I      intronic chr6:42405797(-) A-I      intronic chr6:42389290(-) A-I      intronic chr6:42413781(-) A-I      intronic chr6:42266002(-) A-I      intronic chr6:42319811(-) A-I      intronic chr6:42266034(-) A-I      intronic chr6:42265990(-) A-I      intronic chr6:42266031(-) A-I      intronic chr6:42209827(-) A-I      intronic chr6:42413745(-) A-I      intronic chr6:42266070(-) A-I      intronic chr6:42413768(-) A-I      intronic chr6:42287394(-) A-I      intronic chr6:42235285(-) A-I      intronic chr6:42235020(-) A-I      intronic chr6:42297485(-) A-I      intronic chr6:42346844(-) A-I      intronic chr6:42234135(-) A-I      intronic chr6:42265956(-) A-I      intronic chr6:42266125(-) A-I      intronic chr6:42296019(-) A-I      intronic chr6:42213698(-) A-I      intronic chr6:42287406(-) A-I      intronic chr6:42209472(-) A-I      intronic chr6:42295965(-) A-I      intronic chr6:42298637(-) A-I      intronic chr6:42287363(-) A-I      intronic chr6:42295861(-) A-I      intronic chr6:42413750(-) A-I      intronic chr6:42405792(-) A-I      intronic chr6:42354177(-) A-I      intronic chr6:42324424(-) A-I      intronic chr6:42234871(-) A-I      intronic chr6:42261996(-) A-I      intronic chr6:42234103(-) A-I      intronic chr6:42414691(-) A-I      intronic chr6:42285231(-) A-I      intronic chr6:42211591(-) A-I      intronic chr6:42209311(-) A-I      intronic chr6:42208894(-) A-I      intronic chr6:42380707(-) A-I      intronic chr6:42390715(-) A-I      intronic chr6:42405781(-) A-I      intronic chr6:42380662(-) A-I      intronic chr6:42234828(-) A-I      intronic chr6:42415581(-) A-I      intronic chr6:42235066(-) A-I      intronic chr6:42234896(-) A-I      intronic chr6:42324812(-) A-I      intronic chr6:42288363(-) A-I      intronic chr6:42266180(-) A-I      intronic chr6:42321121(-) A-I      intronic chr6:42266434(-) A-I      intronic chr6:42389295(-) A-I      intronic chr6:42319959(-) A-I      intronic chr6:42209802(-) A-I      intronic chr6:42324824(-) A-I      intronic chr6:42324491(-) A-I      intronic chr6:42381279(-) A-I      intronic chr6:42415540(-) A-I      intronic chr6:42209819(-) A-I      intronic chr6:42405757(-) A-I      intronic chr6:42209296(-) A-I      intronic chr6:42376769(-) A-I      intronic chr6:42266669(-) A-I      intronic chr6:42380589(-) A-I      intronic chr6:42209576(-) A-I      intronic chr6:42209776(-) A-I      intronic chr6:42265991(-) A-I      intronic chr6:42319800(-) A-I      intronic chr6:42208782(-) A-I      intronic chr6:42405756(-) A-I      intronic chr6:42414660(-) A-I      intronic chr6:42288425(-) A-I      intronic chr6:42324589(-) A-I      intronic chr6:42213598(-) A-I      intronic chr6:42352961(-) A-I      intronic chr6:42380602(-) A-I      intronic chr6:42352694(-) A-I      intronic chr6:42235331(-) A-I      intronic chr6:42406163(-) A-I      intronic chr6:42287751(-) A-I      intronic chr6:42415539(-) A-I      intronic chr6:42320878(-) A-I      intronic chr6:42402823(-) A-I      intronic chr6:42234177(-) A-I      intronic chr6:42412924(-) A-I      intronic chr6:42271497(-) A-I      intronic chr6:42413718(-) A-I      intronic chr6:42287466(-) A-I      intronic chr6:42324492(-) A-I      intronic chr6:42234134(-) A-I      intronic chr6:42415457(-) A-I      intronic chr6:42405765(-) A-I      intronic chr6:42273877(-) A-I      intronic chr6:42287778(-) A-I      intronic chr6:42352994(-) A-I      intronic chr6:42390001(-) A-I      intronic chr6:42208727(-) A-I      intronic chr6:42234956(-) A-I      intronic chr6:42413879(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TRERF1	chr6:42265956(-) A-I intron -    22028664 chr6:42265990(-) A-I intron -    22028664 chr6:42265991(-) A-I intron -    22028664 chr6:42265996(-) A-I intron -    22028664 chr6:42266002(-) A-I intron -    22028664 chr6:42266031(-) A-I intron -    22028664 chr6:42266034(-) A-I intron -    22028664 chr6:42266067(-) A-I intron -    22028664 chr6:42266070(-) A-I intron -    22028664 chr6:42266076(-) A-I intron -    22028664 chr6:42266125(-) A-I intron -    22028664 chr6:42208782(-) A-I intron -    21960545 chr6:42209275(-) G-A intron -    22484847 chr6:42209802(-) A-G intron -    22484847 chr6:42261996(-) A-G intron -    22484847 chr6:42266434(-) A-G intron -    22484847 chr6:42287363(-) A-G intron -    22484847 chr6:42287466(-) A-G intron -    22484847 chr6:42319959(-) A-G intron -    22484847 chr6:42352961(-) A-G intron -    22484847 chr6:42389390(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRERF1	chr6:42195985-42195986(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535 chr6:42196014-42196015(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085 chr6:42196020-42196021(-) m6A 3'UTR       24284625//25456834//24981863//28052920//27773535//27371828//22608085 chr6:42196051-42196052(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr6:42196060-42196061(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr6:42196088-42196089(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr6:42196143-42196144(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085 chr6:42196206-42196207(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085 chr6:42196223-42196224(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085 chr6:42196242-42196243(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085 chr6:42196282-42196283(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22608085 chr6:42196346-42196347(-) m6A CDS       24284625//25456834//24981863//27371828 chr6:42196366-42196367(-) m6A CDS       24284625//25456834//27371828 chr6:42200458-42200459(-) m6A CDS       27773535//27371828 chr6:42204105-42204106(-) m6A CDS       24284625//24981863//28052920//27371828 chr6:42211017-42211018(-) m6A CDS       24981863 chr6:42211024-42211025(-) m6A CDS       24981863 chr6:42227246-42227247(-) m6A CDS       24284625 chr6:42227261-42227262(-) m6A CDS       24284625 chr6:42227330-42227331(-) m6A CDS       24284625 chr6:42227368-42227369(-) m6A CDS       24284625//27371828 chr6:42227406-42227407(-) m6A CDS       24284625//27371828 chr6:42231100-42231101(-) m6A CDS//intron       24284625 chr6:42232444-42232445(-) m6A CDS       24284625 chr6:42236024-42236025(-) m6A CDS       24284625//25456834//24981863//28052920//27371828 chr6:42236054-42236055(-) m6A CDS       24284625//25456834//24981863//28052920//27371828 chr6:42236086-42236087(-) m6A CDS       24284625//25456834//24981863//28052920//27371828 chr6:42236103-42236104(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828 chr6:42236117-42236118(-) m6A CDS       24284625//25456834//24981863//28052920//27773535//27371828 chr6:42236267-42236268(-) m6A CDS       24284625//24981863//27773535 chr6:42236584-42236585(-) m6A CDS       24284625//24981863 chr6:42236674-42236675(-) m6A CDS       24284625//24981863 chr6:42236867-42236868(-) m6A 5'UTR//CDS       24284625//24981863 chr6:42236897-42236898(-) m6A 5'UTR//CDS       24284625//24981863 chr6:42236934-42236935(-) m6A 5'UTR//CDS       24284625//24209618//24981863 chr6:42237014-42237015(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27371828 chr6:42237029-42237030(-) m6A CDS//intron       24284625//25456834//24981863//27371828 chr6:42237050-42237051(-) m6A CDS//intron       24284625//25456834//24981863//27371828//22608085 chr6:42237110-42237111(-) m6A CDS//intron       24284625//25456834//24981863//27371828//22575960//22608085 chr6:42237230-42237231(-) m6A CDS//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr6:42237275-42237276(-) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr6:42237303-42237304(-) m6A 5'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr6:42237332-42237333(-) m6A 5'UTR       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr6:42237454-42237455(-) m6A 5'UTR       24284625//24981863 chr6:42237480-42237481(-) m6A 5'UTR       24284625 chr6:42237519-42237520(-) m6A 5'UTR       24284625 chr6:42268410-42268411(-) m6A 5'UTR       24284625//27773535//27371828 chr6:42330737-42330738(-) m6A 5'UTR       24284625//27371828 chr6:42418922-42418923(-) m6A 5'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	TRERF1	Chromatin K562 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: TRERF1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).