Basic Information:

  VIRBase ID:  

VHID00278453

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          UBR7:  NR_038150     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	UBR7
miRBase Accession/Entrez ID	MIMAT0000995	55148
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C14orf130//LICAS

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UBR7	chr14:93683224(+) A-I      intronic chr14:93681768(+) A-I      intronic chr14:93683141(+) A-I      intronic chr14:93683127(+) A-I      intronic chr14:93684659(+) A-I      intronic chr14:93684630(+) A-I      intronic chr14:93684580(+) A-I      intronic chr14:93684579(+) A-I      intronic chr14:93684531(+) A-I      intronic chr14:93684527(+) A-I      intronic chr14:93681864(+) A-I      intronic chr14:93681870(+) A-I      intronic chr14:93683512(+) A-I      intronic chr14:93683183(+) A-I      intronic chr14:93681941(+) A-I      intronic chr14:93682627(+) A-I      intronic chr14:93684494(+) A-I      intronic chr14:93684342(+) A-I      intronic chr14:93683647(+) A-I      intronic chr14:93688968(+) A-I      intronic chr14:93683534(+) A-I      intronic chr14:93683184(+) A-I      intronic chr14:93683171(+) A-I      intronic chr14:93683150(+) A-I      intronic chr14:93683146(+) A-I      intronic chr14:93681888(+) A-I      intronic chr14:93689501(+) A-I      intronic chr14:93683001(+) A-I      intronic chr14:93684329(+) A-I      intronic chr14:93681950(+) A-I      intronic chr14:93684678(+) A-I      intronic chr14:93680487(+) A-I      intronic chr14:93680331(+) A-I      intronic chr14:93689723(+) A-I      intronic chr14:93679399(+) A-I      intronic chr14:93680342(+) A-I      intronic chr14:93680372(+) A-I      intronic chr14:93686323(+) A-I      intronic chr14:93682985(+) A-I      intronic chr14:93683090(+) A-I      intronic chr14:93677396(+) A-I      intronic chr14:93682666(+) A-I      intronic chr14:93681754(+) A-I      intronic chr14:93688978(+) A-I      intronic chr14:93683074(+) A-I      intronic chr14:93682023(+) A-I      intronic chr14:93684164(+) A-I      intronic chr14:93682581(+) A-I      intronic chr14:93684554(+) A-I      intronic chr14:93683144(+) A-I      intronic chr14:93682652(+) A-I      intronic chr14:93682601(+) A-I      intronic chr14:93677421(+) A-I      intronic chr14:93681820(+) A-I      intronic chr14:93689493(+) A-I      intronic chr14:93679428(+) A-I      intronic chr14:93677426(+) A-I      intronic chr14:93682993(+) A-I      intronic chr14:93683399(+) A-I      intronic chr14:93677373(+) A-I      intronic chr14:93680326(+) A-I      intronic chr14:93681884(+) A-I      intronic chr14:93683118(+) A-I      intronic chr14:93681825(+) A-I      intronic chr14:93689690(+) A-I      intronic chr14:93683126(+) A-I      intronic chr14:93682566(+) A-I      intronic chr14:93687596(+) A-I      intronic chr14:93683242(+) A-I      intronic chr14:93688933(+) A-I      intronic chr14:93684555(+) A-I      intronic chr14:93683085(+) A-I      intronic chr14:93681990(+) A-I      intronic chr14:93687781(+) A-I      intronic chr14:93689621(+) A-I      intronic chr14:93690997(+) A-I      intronic chr14:93683182(+) A-I      intronic chr14:93683015(+) A-I      intronic chr14:93681987(+) A-I      intronic chr14:93683151(+) A-I      intronic chr14:93682672(+) A-I      intronic chr14:93679363(+) A-I      intronic chr14:93677423(+) A-I      intronic chr14:93679373(+) A-I      intronic chr14:93683026(+) A-I      intronic chr14:93679429(+) A-I      intronic chr14:93688942(+) A-I      intronic chr14:93680482(+) A-I      intronic chr14:93683556(+) A-I      intronic chr14:93679728(+) A-I      intronic chr14:93681828(+) A-I      intronic chr14:93684297(+) A-I      intronic chr14:93687640(+) A-I      intronic chr14:93682635(+) A-I      intronic chr14:93689622(+) A-I      intronic chr14:93679425(+) A-I      intronic chr14:93681969(+) A-I      intronic chr14:93683197(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	UBR7	chr14:93679363(+) A-I intron -    22327324 chr14:93681888(+) A-I intron -    22327324 chr14:93682666(+) A-I intron -    22327324 chr14:93683118(+) A-I intron -    22327324 chr14:93679363(+) A-G intron -    22484847 chr14:93679373(+) A-G intron -    22484847 chr14:93679425(+) A-G intron -    22484847 chr14:93679428(+) A-G intron -    22484847 chr14:93679429(+) A-G intron -    22484847 chr14:93681828(+) A-G intron -    22484847 chr14:93681870(+) A-G intron -    22484847 chr14:93681888(+) A-G intron -    22484847 chr14:93682581(+) A-G intron -    22484847 chr14:93682627(+) A-G intron -    22484847 chr14:93682635(+) A-G intron -    22484847 chr14:93682652(+) A-G intron -    22484847 chr14:93682666(+) A-G intron -    22484847 chr14:93682672(+) A-G intron -    22484847 chr14:93683026(+) A-G intron -    22484847 chr14:93683118(+) A-G intron -    22484847 chr14:93683126(+) A-G intron -    22484847 chr14:93683197(+) A-G intron -    22484847 chr14:93683242(+) A-G intron -    22484847 chr14:93684554(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UBR7	chr14:93693598-93693599(+) m6A 3'UTR       24981863 chr14:93693761-93693762(+) Y 3'UTR       26075521 chr14:93694370-93694371(+) m6A 3'UTR       24981863 chr14:93694429-93694430(+) m6A 3'UTR       24981863 chr14:93694452-93694453(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	UBR7	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: UBR7

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).