Detail Information

Basic Information:


  VIRBase ID:  

VHID00278250

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:           DEXI:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-1 DEXI
miRBase
Accession/Entrez ID		 MIMAT0000995 28955
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - MYLE

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DEXI
chr16:11026749(-) A-I      intronic
chr16:11026620(-) A-I      intronic
chr16:11025636(-) A-I      intronic
chr16:11025569(-) A-I      intronic
chr16:11025061(-) A-I      intronic
chr16:11025715(-) A-I      intronic
chr16:11026669(-) A-I      intronic
chr16:11025717(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DEXI
chr16:11024926(-) A-I intron -    22327324
chr16:11025445(-) A-I intron -    22327324
chr16:11025491(-) A-I intron -    22327324
chr16:11025549(-) A-I intron -    22327324
chr16:11025617(-) A-I intron -    22327324
chr16:11025637(-) A-I intron -    22327324
chr16:11026729(-) A-I intron -    22327324
chr16:11024926(-) T-C intron -    22484847
chr16:11024962(-) T-C intron -    22484847
chr16:11024972(-) T-C intron -    22484847
chr16:11025000(-) T-C intron -    22484847
chr16:11025017(-) T-C intron -    22484847
chr16:11025065(-) T-C intron -    22484847
chr16:11025071(-) T-C intron -    22484847
chr16:11025075(-) T-C intron -    22484847
chr16:11025439(-) T-C intron -    22484847
chr16:11025445(-) T-C intron -    22484847
chr16:11025446(-) T-C intron -    22484847
chr16:11025467(-) T-C intron -    22484847
chr16:11025491(-) T-C intron -    22484847
chr16:11025548(-) T-C intron -    22484847
chr16:11025549(-) T-C intron -    22484847
chr16:11025593(-) T-C intron -    22484847
chr16:11025617(-) T-C intron -    22484847
chr16:11025626(-) T-C intron -    22484847
chr16:11025633(-) T-C intron -    22484847
chr16:11025637(-) T-C intron -    22484847
chr16:11025654(-) T-C intron -    22484847
chr16:11025689(-) T-C intron -    22484847
chr16:11025723(-) T-C intron -    22484847
chr16:11026648(-) T-C intron -    22484847
chr16:11026662(-) T-C intron -    22484847
chr16:11026669(-) A-G intron -    22484847
chr16:11026674(-) T-C intron -    22484847
chr16:11026729(-) T-C intron -    22484847
chr16:11026743(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DEXI
chr16:11022811-11022812(-) m6A 3'UTR//exon       24284625//27773535//22608085
chr16:11022902-11022903(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr16:11023106-11023107(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:11023113-11023114(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:11023122-11023123(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:11023195-11023196(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:11023275-11023276(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr16:11023340-11023341(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//22608085
chr16:11023367-11023368(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//22608085
chr16:11027749-11027750(-) m6A 3'UTR//intron       24284625//25456834//24981863//27371828
chr16:11027785-11027786(-) m6A 3'UTR//intron       24284625//25456834//27371828
chr16:11027793-11027794(-) m6A 3'UTR//intron       24284625//25456834//27371828
chr16:11027840-11027841(-) m6A 3'UTR//intron       24284625//25456834
chr16:11027852-11027853(-) m6A 3'UTR//intron       24284625//25456834
chr16:11027858-11027859(-) m6A 3'UTR//intron       24284625//25456834
chr16:11032759-11032760(-) m6A intron       27773535
chr16:11032781-11032782(-) m6A intron       27773535
chr16:11032931-11032932(-) m6A intron       24284625//24209618
chr16:11033024-11033025(-) m6A intron       24284625//24209618//22608085
chr16:11033042-11033043(-) m6A intron       24284625//24209618//27773535//22608085
chr16:11033053-11033054(-) m6A intron       24284625//24209618//27773535//22608085
chr16:11033059-11033060(-) m6A intron       24284625//24209618//27773535//22608085
chr16:11033174-11033175(-) m6A intron       24284625//27773535//22608085
chr16:11033280-11033281(-) m6A intron       -
chr16:11033329-11033330(-) m6A intron       -
chr16:11035447-11035448(-) m6A 3'UTR//exon       24284625//25456834//24981863//22608085
chr16:11035520-11035521(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085
chr16:11035656-11035657(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:11035671-11035672(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:11035677-11035678(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr16:11035999-11036000(-) m6A 5'UTR       24209618//27371828//27773536
chr16:11036202-11036203(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr16:11036213-11036214(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085
chr16:11036248-11036249(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-1
Exosome Jurkat-derived T cell line (J77cl20)     21505438
DEXI
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-1
Interactor2: DEXI

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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