Detail Information

Basic Information:


  VIRBase ID:  

VHID00278130

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:           MMD:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-1 MMD
miRBase
Accession/Entrez ID		 MIMAT0000995 23531
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - MMA//MMD1//PAQR11

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MMD
chr17:53483893(-) A-I      intronic
chr17:53475134(-) A-I      intronic
chr17:53486222(-) A-I      intronic
chr17:53477833(-) A-I      intronic
chr17:53474601(-) A-I      intronic
chr17:53482729(-) A-I      intronic
chr17:53477847(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MMD
chr17:53471027-53471028(-) m6A 3'UTR       27773535
chr17:53471042-53471043(-) m6A 3'UTR       27773535
chr17:53471103-53471104(-) m6A 3'UTR       27773535
chr17:53471213-53471214(-) m6A 3'UTR       27773535
chr17:53471426-53471427(-) m6A 3'UTR       24981863
chr17:53471431-53471432(-) m6A 3'UTR       24981863
chr17:53471454-53471455(-) m6A 3'UTR       24981863
chr17:53471465-53471466(-) m6A 3'UTR       24981863
chr17:53497667-53497668(-) m6A exon//intron       24209618//27371828//22608085
chr17:53497670-53497671(-) Am exon//intron       -
chr17:53497687-53497688(-) m6A exon//intron       24209618//22608085
chr17:53497709-53497710(-) m6A exon//intron       24209618//24981863//22608085
chr17:53497742-53497743(-) m6A exon//intron       24209618//24981863//22608085
chr17:53497814-53497815(-) m6A exon//intron       27773536//22608085
chr17:53499161-53499162(-) m6A 5'UTR       24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-1
Exosome Jurkat-derived T cell line (J77cl20)     21505438
MMD
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-1
Interactor2: MMD

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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