Basic Information:

  VIRBase ID:  

VHID00278116

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          HEY1:  NM_012258     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	HEY1
miRBase Accession/Entrez ID	MIMAT0000995	23462
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BHLHb31//CHF2//HERP2//HESR1//hHRT1//HRT-1//NERP2//OAF1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HEY1	chr8:80676251-80676252(-) m6A 3'UTR       27773535 chr8:80676305-80676306(-) m6A 3'UTR       27773535 chr8:80676438-80676439(-) m6A 3'UTR       27773535 chr8:80676524-80676525(-) Y 3'UTR       26075521 chr8:80677288-80677289(-) m6A 3'UTR//exon       24209618//24981863//22608085 chr8:80677369-80677370(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//22608085 chr8:80677418-80677419(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr8:80677452-80677453(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr8:80677471-80677472(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr8:80677590-80677591(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr8:80677623-80677624(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr8:80677701-80677702(-) m6A CDS//exon       24284625//24209618//25456834//27371828//27773536//22608085 chr8:80677782-80677783(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr8:80677793-80677794(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr8:80677809-80677810(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr8:80677908-80677909(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27371828//27773536//22608085 chr8:80677975-80677976(-) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chr8:80678442-80678443(-) m6A CDS//intron       24284625//25456834//24981863//22608085 chr8:80678454-80678455(-) m6A CDS//intron       24284625//25456834//24981863//22608085 chr8:80679005-80679006(-) m6A exon//intron       22608085 chr8:80679526-80679527(-) m6A 5'UTR//CDS//exon       27773535//27773536 chr8:80679660-80679661(-) m6A 5'UTR//exon//intron       27773536 chr8:80679730-80679731(-) m6A exon//intron       27773536 chr8:80679846-80679847(-) m6A CDS//exon       24284625//27773536 chr8:80679863-80679864(-) m6A CDS//exon       24284625//24981863//27773536 chr8:80679914-80679915(-) m6A 5'UTR//exon       24284625//24981863//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	HEY1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: HEY1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).