Basic Information:

  VIRBase ID:  

VHID00277961

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:  MIMAT0000995          TCERG1:  NM_001382548     

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Interactor Information:

	Interactor1	Interactor2
Symbol	ebv-miR-BHRF1-1	TCERG1
miRBase Accession/Entrez ID	MIMAT0000995	10915
Organism	Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	CA150//TAF2S//Urn1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TCERG1	chr5:145867138(+) A-I      intronic chr5:145875601(+) A-I      intronic chr5:145875622(+) A-I      intronic chr5:145866561(+) A-I      intronic chr5:145875545(+) A-I      intronic chr5:145876310(+) A-I      intronic chr5:145875539(+) A-I      intronic chr5:145875529(+) A-I      intronic chr5:145875440(+) A-I      intronic chr5:145867037(+) A-I      intronic chr5:145866542(+) A-I      intronic chr5:145866405(+) A-I      intronic chr5:145866388(+) A-I      intronic chr5:145866383(+) A-I      intronic chr5:145865455(+) A-I      intronic chr5:145876946(+) A-I      intronic chr5:145880329(+) A-I      intronic chr5:145880553(+) A-I      intronic chr5:145876567(+) A-I      intronic chr5:145865276(+) A-I      intronic chr5:145837508(+) A-I      intronic chr5:145867213(+) A-I      intronic chr5:145876597(+) A-I      intronic chr5:145876617(+) A-I      intronic chr5:145875637(+) A-I      intronic chr5:145837471(+) A-I      intronic chr5:145866495(+) A-I      intronic chr5:145867137(+) A-I      intronic chr5:145867155(+) A-I      intronic chr5:145834335(+) A-I      intronic chr5:145880388(+) A-I      intronic chr5:145885469(+) A-I      intronic chr5:145832239(+) A-I      intronic chr5:145866503(+) A-I      intronic chr5:145876664(+) A-I      intronic chr5:145867135(+) A-I      intronic chr5:145876400(+) A-I      intronic chr5:145876709(+) A-I      intronic chr5:145833627(+) A-I      intronic chr5:145881514(+) A-I      intronic chr5:145876811(+) A-I      intronic chr5:145876592(+) A-I      intronic chr5:145856400(+) A-I      intronic chr5:145833503(+) A-I      intronic chr5:145867236(+) A-I      intronic chr5:145867199(+) A-I      intronic chr5:145834293(+) A-I      intronic chr5:145876623(+) A-I      intronic chr5:145881587(+) A-I      intronic chr5:145866506(+) A-I      intronic chr5:145876570(+) A-I      intronic chr5:145832279(+) A-I      intronic chr5:145876560(+) A-I      intronic chr5:145880450(+) A-I      intronic chr5:145880434(+) A-I      intronic chr5:145866546(+) A-I      intronic chr5:145865423(+) A-I      intronic chr5:145833685(+) A-I      intronic chr5:145876614(+) A-I      intronic chr5:145865496(+) A-I      intronic chr5:145880468(+) A-I      intronic chr5:145875538(+) A-I      intronic chr5:145867200(+) A-I      intronic chr5:145833305(+) A-I      intronic chr5:145833653(+) A-I      intronic chr5:145866382(+) A-I      intronic chr5:145885380(+) A-I      intronic chr5:145876873(+) A-I      intronic chr5:145865375(+) A-I      intronic chr5:145867145(+) A-I      intronic chr5:145884488(+) A-I      intronic chr5:145876797(+) A-I      intronic chr5:145867187(+) A-I      intronic chr5:145866658(+) A-I      intronic chr5:145866494(+) A-I      intronic chr5:145865331(+) A-I      intronic chr5:145875605(+) A-I      intronic chr5:145876841(+) A-I      intronic chr5:145880475(+) A-I      intronic chr5:145877002(+) A-I      intronic chr5:145867280(+) A-I      intronic chr5:145865493(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TCERG1	chr5:145876797(+) A-I intron -    22327324 chr5:145865358(+) A-I intron -    21960545 chr5:145866494(+) A-I intron -    21960545 chr5:145875446(+) A-I intron -    21960545 chr5:145875538(+) A-I intron -    21960545 chr5:145832227(+) A-G intron -    22484847 chr5:145832246(+) A-G intron -    22484847 chr5:145834293(+) A-G intron -    22484847 chr5:145834318(+) A-G intron -    22484847 chr5:145845322(+) C-T intron -    22484847 chr5:145856400(+) A-G intron -    22484847 chr5:145856403(+) G-A intron -    22484847 chr5:145865358(+) A-G intron -    22484847 chr5:145865375(+) A-G intron -    22484847 chr5:145865400(+) A-G intron -    22484847 chr5:145865423(+) A-G intron -    22484847 chr5:145865493(+) A-G intron -    22484847 chr5:145866396(+) A-G intron -    22484847 chr5:145866494(+) A-G intron -    22484847 chr5:145866506(+) A-G intron -    22484847 chr5:145866546(+) A-G intron -    22484847 chr5:145867187(+) A-G intron -    22484847 chr5:145870829(+) T-C intron -    22484847 chr5:145875463(+) A-G intron -    22484847 chr5:145875538(+) A-G intron -    22484847 chr5:145875595(+) A-G intron -    22484847 chr5:145875605(+) A-G intron -    22484847 chr5:145876357(+) A-G intron -    22484847 chr5:145876400(+) A-G intron -    22484847 chr5:145876623(+) A-G intron -    22484847 chr5:145876629(+) A-G intron -    22484847 chr5:145876797(+) A-G intron -    22484847 chr5:145876841(+) A-G intron -    22484847 chr5:145876863(+) A-G intron -    22484847 chr5:145876957(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TCERG1	chr5:145836747-145836748(+) m6A CDS//exon       24284625//24981863 chr5:145838467-145838468(+) m6A CDS//exon       26404942 chr5:145838485-145838486(+) m6A CDS//exon       26404942 chr5:145838523-145838524(+) m6A CDS//exon       26404942 chr5:145838890-145838891(+) m6A CDS//exon       24981863//26404942 chr5:145841596-145841597(+) m6A exon//intron       24981863 chr5:145843133-145843134(+) m6A CDS//exon       24284625//24981863 chr5:145843211-145843212(+) m6A CDS//exon       24284625//24981863 chr5:145847944-145847945(+) m6A CDS//intron       24284625 chr5:145847962-145847963(+) m6A CDS//intron       24284625 chr5:145849213-145849214(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145849225-145849226(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145849229-145849230(+) Cm CDS//exon       - chr5:145849240-145849241(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145849261-145849262(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145849284-145849285(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145849293-145849294(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145849344-145849345(+) m6A exon//intron       24981863//27773535//22608085 chr5:145850235-145850236(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chr5:145858211-145858212(+) m6A CDS//exon       24981863//27773535 chr5:145859600-145859601(+) m6A CDS//exon       24981863//27773535 chr5:145859736-145859737(+) m6A exon//intron       24981863 chr5:145862171-145862172(+) m6A CDS//exon       24981863 chr5:145862270-145862271(+) m6A CDS//exon       24981863 chr5:145863188-145863189(+) m6A CDS//exon       24981863//27773535 chr5:145872503-145872504(+) m6A CDS//exon       24981863//27773535 chr5:145878169-145878170(+) m6A CDS//exon       24981863//27773535 chr5:145878234-145878235(+) m6A CDS//exon       24981863//27773535 chr5:145882957-145882958(+) m6A CDS//exon       27773535 chr5:145882980-145882981(+) m6A CDS//exon       27773535 chr5:145883010-145883011(+) m6A CDS//exon       24981863//27773535 chr5:145883067-145883068(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145883077-145883078(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145883393-145883394(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145883484-145883485(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145883498-145883499(+) Tm CDS//exon       - chr5:145888712-145888713(+) m6A CDS//exon       24981863//27773535 chr5:145888741-145888742(+) m6A CDS//exon       24981863//27773535 chr5:145888788-145888789(+) m6A CDS//exon       24981863//27773535//22608085 chr5:145889693-145889694(+) m6A 3'UTR//exon//intron       24284625//24981863//27773535//22608085 chr5:145889719-145889720(+) m6A 3'UTR//exon//intron       24284625//24981863//27773535//22608085 chr5:145890089-145890090(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:145890114-145890115(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr5:145890302-145890303(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:145890314-145890315(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:145890336-145890337(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:145890347-145890348(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:145890352-145890353(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr5:145890546-145890547(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr5:145890570-145890571(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr5:145890581-145890582(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr5:145890640-145890641(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085 chr5:145890690-145890691(+) m6A 3'UTR//exon       24209618//24981863 chr5:145890835-145890836(+) m6A 3'UTR//exon       27773535 chr5:145890870-145890871(+) m6A 3'UTR//exon       27773535 chr5:145890882-145890883(+) m6A 3'UTR//exon       27773535 chr5:145890930-145890931(+) m6A 3'UTR//exon       27773535 chr5:145890963-145890964(+) m6A 3'UTR//exon       27773535 chr5:145890987-145890988(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ebv-miR-BHRF1-1	Exosome Jurkat-derived T cell line (J77cl20)     21505438
	TCERG1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: ebv-miR-BHRF1-1
Interactor2: TCERG1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VIRmiRNA//VmiReg

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	Downregulation
Description	We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).