Detail Information

Basic Information:


  VIRBase ID:  

VHID00277899

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:           HMG20A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-1 HMG20A
miRBase
Accession/Entrez ID		 MIMAT0000995 10363
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - HMGX1//HMGXB1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR HMG20A
chr15:77768759(+) A-I      intronic
chr15:77758545(+) A-I      intronic
chr15:77772911(+) A-I      intronic
chr15:77772909(+) A-I      intronic
chr15:77772861(+) A-I      intronic
chr15:77764890(+) A-I      intronic
chr15:77757838(+) A-I      intronic
chr15:77764681(+) A-I      intronic
chr15:77729938(+) A-I      intronic
chr15:77730076(+) A-I      intronic
chr15:77757369(+) A-I      intronic
chr15:77764721(+) A-I      intronic
chr15:77757877(+) A-I      intronic
chr15:77764782(+) A-I      intronic
chr15:77757867(+) A-I      intronic
chr15:77768561(+) A-I      intronic
chr15:77757769(+) A-I      intronic
chr15:77757757(+) A-I      intronic
chr15:77757583(+) A-I      intronic
chr15:77764783(+) A-I      intronic
chr15:77764807(+) A-I      intronic
chr15:77768659(+) A-I      intronic
chr15:77768662(+) A-I      intronic
chr15:77768667(+) A-I      intronic
chr15:77768716(+) A-I      intronic
chr15:77772694(+) A-I      intronic
chr15:77758459(+) A-I      intronic
chr15:77757958(+) A-I      intronic
chr15:77772898(+) A-I      intronic
chr15:77757425(+) A-I      intronic
chr15:77757401(+) A-I      intronic
chr15:77757373(+) A-I      intronic
chr15:77758638(+) A-I      intronic
chr15:77764717(+) A-I      intronic
chr15:77757557(+) A-I      intronic
chr15:77757999(+) A-I      intronic
chr15:77757998(+) A-I      intronic
chr15:77758465(+) A-I      intronic
chr15:77772727(+) A-I      intronic
chr15:77758677(+) A-I      intronic
chr15:77758712(+) A-I      intronic
chr15:77758713(+) A-I      intronic
chr15:77757497(+) A-I      intronic
chr15:77768668(+) A-I      intronic
chr15:77764774(+) A-I      intronic
chr15:77757831(+) A-I      intronic
chr15:77757972(+) A-I      intronic
chr15:77742495(+) A-I      intronic
chr15:77742606(+) A-I      intronic
chr15:77758547(+) A-I      intronic
chr15:77753263(+) A-I      intronic
chr15:77757392(+) A-I      intronic
chr15:77757864(+) A-I      intronic
chr15:77758513(+) A-I      intronic
chr15:77764756(+) A-I      intronic
chr15:77742602(+) A-I      intronic
chr15:77764820(+) A-I      intronic
chr15:77721436(+) A-I      intronic
chr15:77772535(+) A-I      intronic
chr15:77768670(+) A-I      intronic
chr15:77758537(+) A-I      intronic
chr15:77757807(+) A-I      intronic
chr15:77764792(+) A-I      intronic
chr15:77757971(+) A-I      intronic
chr15:77764680(+) A-I      intronic
chr15:77757863(+) A-I      intronic
chr15:77772537(+) A-I      intronic
chr15:77757799(+) A-I      intronic
chr15:77757400(+) A-I      intronic
chr15:77768707(+) A-I      intronic
chr15:77758576(+) A-I      intronic
chr15:77758508(+) A-I      intronic
chr15:77757959(+) A-I      intronic
chr15:77758624(+) A-I      intronic
chr15:77721201(+) A-I      intronic
chr15:77758544(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED HMG20A
chr15:77757863(+) A-I intron -    22327324
chr15:77757864(+) A-I intron -    22327324
chr15:77758513(+) A-I intron -    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase HMG20A
chr15:77712775-77712776(+) m6A 5'UTR       25456834
chr15:77712829-77712830(+) m6A 5'UTR       25456834
chr15:77713193-77713194(+) m6A 5'UTR//intron       24981863//27773535//22608085
chr15:77713301-77713302(+) m6A 5'UTR//exon//intron       24981863//22608085
chr15:77750756-77750757(+) m6A 5'UTR//CDS//exon//intron       -
chr15:77756710-77756711(+) m6A 5'UTR//CDS//exon       27773535
chr15:77756767-77756768(+) m6A exon//intron       24981863//27773535
chr15:77759483-77759484(+) m6A 5'UTR//CDS//intron       24284625//24981863
chr15:77759494-77759495(+) m6A 5'UTR//CDS//intron       24284625//24981863
chr15:77759555-77759556(+) m6A 3'UTR//CDS       24284625//24981863//27773535
chr15:77759573-77759574(+) m6A 3'UTR//CDS       24981863//27773535
chr15:77759627-77759628(+) m6A 3'UTR//CDS       24981863//27773535
chr15:77759645-77759646(+) m6A 3'UTR//CDS       24981863//27773535
chr15:77763270-77763271(+) m6A 3'UTR//CDS       24981863//27773535
chr15:77763298-77763299(+) m6A 3'UTR//CDS       24981863//27773535
chr15:77763304-77763305(+) m6A 3'UTR//CDS       24981863//27773535
chr15:77763317-77763318(+) m6A 3'UTR//CDS       24981863//27773535
chr15:77763347-77763348(+) m6A CDS       24981863
chr15:77763354-77763355(+) m6A CDS       24981863
chr15:77769902-77769903(+) m6A CDS       24981863
chr15:77769960-77769961(+) m6A CDS       24981863
chr15:77770803-77770804(+) m6A CDS//exon       24284625//24981863//22608085
chr15:77771531-77771532(+) m6A CDS//exon       24284625//24981863//22608085
chr15:77771544-77771545(+) m6A CDS//exon       24284625//24981863//22608085
chr15:77771565-77771566(+) m6A CDS//exon       24284625//24981863//26404942//22608085
chr15:77771601-77771602(+) m6A CDS//exon       24284625//24981863//26404942//22608085
chr15:77771610-77771611(+) m6A CDS//exon       24284625//24981863//26404942//22608085
chr15:77771640-77771641(+) m6A CDS//exon       24284625//24981863//26404942//27773535//22608085
chr15:77771724-77771725(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr15:77771744-77771745(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr15:77771766-77771767(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr15:77771777-77771778(+) m6A 3'UTR//intron       24284625//24981863//22608085
chr15:77775319-77775320(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085
chr15:77775383-77775384(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22608085
chr15:77775655-77775656(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr15:77775679-77775680(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085
chr15:77775802-77775803(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr15:77775850-77775851(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085
chr15:77777366-77777367(+) m6A 3'UTR//exon       24284625
chr15:77777386-77777387(+) m6A 3'UTR//exon       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-1
Exosome Jurkat-derived T cell line (J77cl20)     21505438
HMG20A
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-1
Interactor2: HMG20A

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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