Detail Information

Basic Information:


  VIRBase ID:  

VHID00277791

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:           CLOCK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-1 CLOCK
miRBase
Accession/Entrez ID		 MIMAT0000995 9575
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - bHLHe8//KAT13D

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CLOCK
chr4:56405658(-) A-I      intronic
chr4:56405617(-) A-I      intronic
chr4:56405290(-) A-I      intronic
chr4:56405204(-) A-I      intronic
chr4:56405195(-) A-I      intronic
chr4:56405182(-) A-I      intronic
chr4:56395485(-) A-I      intronic
chr4:56405181(-) A-I      intronic
chr4:56403725(-) A-I      intronic
chr4:56396830(-) A-I      intronic
chr4:56394405(-) A-I      intronic
chr4:56394430(-) A-I      intronic
chr4:56395437(-) A-I      intronic
chr4:56313164(-) A-I      intronic
chr4:56313163(-) A-I      intronic
chr4:56313133(-) A-I      intronic
chr4:56313127(-) A-I      intronic
chr4:56313117(-) A-I      intronic
chr4:56405683(-) A-I      intronic
chr4:56323066(-) A-I      intronic
chr4:56323031(-) A-I      intronic
chr4:56405672(-) A-I      intronic
chr4:56346588(-) A-I      intronic
chr4:56313517(-) A-I      intronic
chr4:56405671(-) A-I      intronic
chr4:56394329(-) A-I      intronic
chr4:56394152(-) A-I      intronic
chr4:56394147(-) A-I      intronic
chr4:56394056(-) A-I      intronic
chr4:56394027(-) A-I      intronic
chr4:56405340(-) A-I      intronic
chr4:56332007(-) A-I      intronic
chr4:56313474(-) A-I      intronic
chr4:56313449(-) A-I      intronic
chr4:56312334(-) A-I      intronic
chr4:56312272(-) A-I      intronic
chr4:56391770(-) A-I      intronic
chr4:56387631(-) A-I      intronic
chr4:56387550(-) A-I      intronic
chr4:56387546(-) A-I      intronic
chr4:56395577(-) A-I      intronic
chr4:56387539(-) A-I      intronic
chr4:56385496(-) A-I      intronic
chr4:56385470(-) A-I      intronic
chr4:56385373(-) A-I      intronic
chr4:56374875(-) A-I      intronic
chr4:56374869(-) A-I      intronic
chr4:56373776(-) A-I      intronic
chr4:56373770(-) A-I      intronic
chr4:56396770(-) A-I      intronic
chr4:56396739(-) A-I      intronic
chr4:56373370(-) A-I      intronic
chr4:56405629(-) A-I      intronic
chr4:56405613(-) A-I      intronic
chr4:56405304(-) A-I      intronic
chr4:56373365(-) A-I      intronic
chr4:56405274(-) A-I      intronic
chr4:56405258(-) A-I      intronic
chr4:56396738(-) A-I      intronic
chr4:56396725(-) A-I      intronic
chr4:56396724(-) A-I      intronic
chr4:56396685(-) A-I      intronic
chr4:56396737(-) A-I      intronic
chr4:56395490(-) A-I      intronic
chr4:56395558(-) A-I      intronic
chr4:56373338(-) A-I      intronic
chr4:56373301(-) A-I      intronic
chr4:56372924(-) A-I      intronic
chr4:56372923(-) A-I      intronic
chr4:56372488(-) A-I      intronic
chr4:56372478(-) A-I      intronic
chr4:56372457(-) A-I      intronic
chr4:56372452(-) A-I      intronic
chr4:56371809(-) A-I      intronic
chr4:56371785(-) A-I      intronic
chr4:56371779(-) A-I      intronic
chr4:56371660(-) A-I      intronic
chr4:56371639(-) A-I      intronic
chr4:56371612(-) A-I      intronic
chr4:56371572(-) A-I      intronic
chr4:56347001(-) A-I      intronic
chr4:56346971(-) A-I      intronic
chr4:56346877(-) A-I      intronic
chr4:56346865(-) A-I      intronic
chr4:56346792(-) A-I      intronic
chr4:56346679(-) A-I      intronic
chr4:56346651(-) A-I      intronic
chr4:56346629(-) A-I      intronic
chr4:56346621(-) A-I      intronic
chr4:56312336(-) A-I      intronic
chr4:56346560(-) A-I      intronic
chr4:56346461(-) A-I      intronic
chr4:56331987(-) A-I      intronic
chr4:56331971(-) A-I      intronic
chr4:56331893(-) A-I      intronic
chr4:56324514(-) A-I      intronic
chr4:56323025(-) A-I      intronic
chr4:56323023(-) A-I      intronic
chr4:56323019(-) A-I      intronic
chr4:56313412(-) A-I      intronic
chr4:56313362(-) A-I      intronic
chr4:56313275(-) A-I      intronic
chr4:56312384(-) A-I      intronic
chr4:56312321(-) A-I      intronic
chr4:56311982(-) A-I      intronic
chr4:56311841(-) A-I      intronic
chr4:56406339(-) A-I      intronic
chr4:56395509(-) A-I      intronic
chr4:56387603(-) A-I      intronic
chr4:56387558(-) A-I      intronic
chr4:56395454(-) A-I      intronic
chr4:56387554(-) A-I      intronic
chr4:56323089(-) A-I      intronic
chr4:56323079(-) A-I      intronic
chr4:56323074(-) A-I      intronic
chr4:56406312(-) A-I      intronic
chr4:56406291(-) A-I      intronic
chr4:56395578(-) A-I      intronic
chr4:56406267(-) A-I      intronic
chr4:56311854(-) A-I      intronic
chr4:56391530(-) A-I      intronic
chr4:56401271(-) A-I      intronic
chr4:56373263(-) A-I      intronic
chr4:56391766(-) A-I      intronic
chr4:56385402(-) A-I      intronic
chr4:56408381(-) A-I      intronic
chr4:56396779(-) A-I      intronic
chr4:56346712(-) A-I      intronic
chr4:56331946(-) A-I      intronic
chr4:56395363(-) A-I      intronic
chr4:56322660(-) A-I      intronic
chr4:56396860(-) A-I      intronic
chr4:56391396(-) A-I      intronic
chr4:56395360(-) A-I      intronic
chr4:56401260(-) A-I      intronic
chr4:56311896(-) A-I      intronic
chr4:56396750(-) A-I      intronic
chr4:56335390(-) A-I      intronic
chr4:56312459(-) A-I      intronic
chr4:56399987(-) A-I      intronic
chr4:56323046(-) A-I      intronic
chr4:56336024(-) A-I      intronic
chr4:56311962(-) A-I      intronic
chr4:56312399(-) A-I      intronic
chr4:56366686(-) A-I      intronic
chr4:56405194(-) A-I      intronic
chr4:56395441(-) A-I      intronic
chr4:56312009(-) A-I      intronic
chr4:56392859(-) A-I      intronic
chr4:56346592(-) A-I      intronic
chr4:56312036(-) A-I      intronic
chr4:56409244(-) A-I      intronic
chr4:56391737(-) A-I      intronic
chr4:56334385(-) A-I      intronic
chr4:56395515(-) A-I      intronic
chr4:56391526(-) A-I      intronic
chr4:56312323(-) A-I      intronic
chr4:56346542(-) A-I      intronic
chr4:56394037(-) A-I      intronic
chr4:56406212(-) A-I      intronic
chr4:56409869(-) A-I      intronic
chr4:56409183(-) A-I      intronic
chr4:56391435(-) A-I      intronic
chr4:56398886(-) A-I      intronic
chr4:56395535(-) A-I      intronic
chr4:56313485(-) A-I      intronic
chr4:56391874(-) A-I      intronic
chr4:56312455(-) A-I      intronic
chr4:56336040(-) A-I      intronic
chr4:56387604(-) A-I      intronic
chr4:56395466(-) A-I      intronic
chr4:56346869(-) A-I      intronic
chr4:56408291(-) A-I      intronic
chr4:56374898(-) A-I      intronic
chr4:56391707(-) A-I      intronic
chr4:56322729(-) A-I      intronic
chr4:56398813(-) A-I      intronic
chr4:56399994(-) A-I      intronic
chr4:56395428(-) A-I      intronic
chr4:56406378(-) A-I      intronic
chr4:56367086(-) A-I      intronic
chr4:56312464(-) A-I      intronic
chr4:56385357(-) A-I      intronic
chr4:56396841(-) A-I      intronic
chr4:56395433(-) A-I      intronic
chr4:56373224(-) A-I      intronic
chr4:56396895(-) A-I      intronic
chr4:56373360(-) A-I      intronic
chr4:56371586(-) A-I      intronic
chr4:56405511(-) A-I      intronic
chr4:56374807(-) A-I      intronic
chr4:56312444(-) A-I      intronic
chr4:56312393(-) A-I      intronic
chr4:56346692(-) A-I      intronic
chr4:56409240(-) A-I      intronic
chr4:56401193(-) A-I      intronic
chr4:56395497(-) A-I      intronic
chr4:56331902(-) A-I      intronic
chr4:56405641(-) A-I      intronic
chr4:56322986(-) A-I      intronic
chr4:56375023(-) A-I      intronic
chr4:56346652(-) A-I      intronic
chr4:56322560(-) A-I      intronic
chr4:56373774(-) A-I      intronic
chr4:56346459(-) A-I      intronic
chr4:56395464(-) A-I      intronic
chr4:56311818(-) A-I      intronic
chr4:56385479(-) A-I      intronic
chr4:56373423(-) A-I      intronic
chr4:56313331(-) A-I      intronic
chr4:56313468(-) A-I      intronic
chr4:56401268(-) A-I      intronic
chr4:56373679(-) A-I      intronic
chr4:56405619(-) A-I      intronic
chr4:56313422(-) A-I      intronic
chr4:56311886(-) A-I      intronic
chr4:56405350(-) A-I      intronic
chr4:56387589(-) A-I      intronic
chr4:56312333(-) A-I      intronic
chr4:56403866(-) A-I      intronic
chr4:56346564(-) A-I      intronic
chr4:56385922(-) A-I      intronic
chr4:56396754(-) A-I      intronic
chr4:56398932(-) A-I      intronic
chr4:56409202(-) A-I      intronic
chr4:56372790(-) A-I      intronic
chr4:56312382(-) A-I      intronic
chr4:56373246(-) A-I      intronic
chr4:56387586(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CLOCK
chr4:56309656(-) C-T intron -    22484847
chr4:56309657(-) T-C intron -    22484847
chr4:56312438(-) T-C intron -    22484847
chr4:56312453(-) T-C intron -    22484847
chr4:56312455(-) A-G intron -    22484847
chr4:56312464(-) A-G intron -    22484847
chr4:56312495(-) T-C intron -    22484847
chr4:56313331(-) A-G intron -    22484847
chr4:56324352(-) A-G intron -    22484847
chr4:56324425(-) A-G intron -    22484847
chr4:56331931(-) A-G intron -    22484847
chr4:56332056(-) G-A intron -    22484847
chr4:56346489(-) A-G intron -    22484847
chr4:56346712(-) A-G intron -    22484847
chr4:56346869(-) A-G intron -    22484847
chr4:56347057(-) G-T intron -    22484847
chr4:56373360(-) A-G intron -    22484847
chr4:56373423(-) A-G intron -    22484847
chr4:56373679(-) A-G intron -    22484847
chr4:56374898(-) A-G intron -    22484847
chr4:56385342(-) A-G intron -    22484847
chr4:56385357(-) A-G intron -    22484847
chr4:56385479(-) A-G intron -    22484847
chr4:56385845(-) A-G intron -    22484847
chr4:56387523(-) A-G intron -    22484847
chr4:56391620(-) A-G intron -    22484847
chr4:56391635(-) A-G intron -    22484847
chr4:56391874(-) A-G intron -    22484847
chr4:56394123(-) A-G intron -    22484847
chr4:56395428(-) A-G intron -    22484847
chr4:56395433(-) A-G intron -    22484847
chr4:56395466(-) A-G intron -    22484847
chr4:56396841(-) A-G intron -    22484847
chr4:56399994(-) A-G intron -    22484847
chr4:56401978(-) A-G intron -    22484847
chr4:56403709(-) A-G intron -    22484847
chr4:56403866(-) A-G intron -    22484847
chr4:56405350(-) A-G intron -    22484847
chr4:56406454(-) A-G intron -    22484847
chr4:56408291(-) A-G intron -    22484847
chr4:56408381(-) A-G intron -    22484847
chr4:56409244(-) A-G intron -    22484847
chr4:56409284(-) A-G intron -    22484847
chr4:56409869(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CLOCK
chr4:56294236-56294237(-) m6A 3'UTR       27773535
chr4:56294297-56294298(-) m6A 3'UTR       27773535
chr4:56294303-56294304(-) m6A 3'UTR       27773535
chr4:56299078-56299079(-) m6A 3'UTR//exon       24981863
chr4:56299101-56299102(-) m6A 3'UTR//exon       24981863
chr4:56299787-56299788(-) m6A 3'UTR//exon       24981863
chr4:56300989-56300990(-) m6A 3'UTR//exon       27773535
chr4:56301086-56301087(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr4:56301139-56301140(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr4:56301151-56301152(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr4:56301198-56301199(-) m6A 3'UTR//exon       24209618//24981863//27773535//22608085
chr4:56301622-56301623(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535
chr4:56304561-56304562(-) m6A CDS//exon       24284625//24209618//27773535
chr4:56308610-56308611(-) m6A CDS//exon       27773535
chr4:56308649-56308650(-) m6A CDS//exon       27773535
chr4:56308746-56308747(-) m6A CDS//exon       27773535
chr4:56308764-56308765(-) m6A CDS//exon       27773535
chr4:56309876-56309877(-) m6A CDS//exon       27773535
chr4:56309913-56309914(-) m6A CDS//exon       27773535
chr4:56316265-56316266(-) m6A CDS       27773535
chr4:56412673-56412674(-) m1A 5'UTR//exon//intron       26863196//26863410
chr4:56412693-56412694(-) m6A 5'UTR//exon//intron       25456834//24981863//27773536
chr4:56412733-56412734(-) m6A exon//intron       25456834//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-1
Exosome Jurkat-derived T cell line (J77cl20)     21505438
CLOCK
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-1
Interactor2: CLOCK

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//PITA//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression Downregulation
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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