Detail Information

Basic Information:


  VIRBase ID:  

VHID00277786

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      ebv-miR-BHRF1-1:           VPS4B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol ebv-miR-BHRF1-1 VPS4B
miRBase
Accession/Entrez ID		 MIMAT0000995 9525
Organism Human gammaherpesvirus 4 (Epstein-Barr virus, EPV) Homo sapiens
Category miRNA mRNA
Alias - MIG1//SKD1//SKD1B//VPS4-2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VPS4B
chr18:61086550(-) A-I      intronic
chr18:61083524(-) A-I      intronic
chr18:61057471(-) A-I      3'UTR
chr18:61057454(-) A-I      3'UTR
chr18:61086606(-) A-I      intronic
chr18:61083484(-) A-I      intronic
chr18:61057485(-) A-I      3'UTR
chr18:61057489(-) A-I      3'UTR
chr18:61057501(-) A-I      3'UTR
chr18:61083486(-) A-I      intronic
chr18:61083518(-) A-I      intronic
chr18:61083499(-) A-I      intronic
chr18:61083483(-) A-I      intronic
chr18:61083533(-) A-I      intronic
chr18:61085813(-) A-I      intronic
chr18:61086464(-) A-I      intronic
chr18:61086490(-) A-I      intronic
chr18:61065540(-) A-I      intronic
chr18:61086636(-) A-I      intronic
chr18:61088127(-) A-I      intronic
chr18:61088149(-) A-I      intronic
chr18:61088195(-) A-I      intronic
chr18:61088267(-) A-I      intronic
chr18:61063533(-) A-I      intronic
chr18:61061205(-) A-I      intronic
chr18:61061190(-) A-I      intronic
chr18:61061188(-) A-I      intronic
chr18:61065725(-) A-I      intronic
chr18:61065726(-) A-I      intronic
chr18:61065946(-) A-I      intronic
chr18:61065960(-) A-I      intronic
chr18:61065981(-) A-I      intronic
chr18:61065986(-) A-I      intronic
chr18:61067176(-) A-I      intronic
chr18:61067183(-) A-I      intronic
chr18:61067192(-) A-I      intronic
chr18:61068573(-) A-I      intronic
chr18:61068580(-) A-I      intronic
chr18:61068584(-) A-I      intronic
chr18:61068585(-) A-I      intronic
chr18:61065563(-) A-I      intronic
chr18:61065632(-) A-I      intronic
chr18:61065545(-) A-I      intronic
chr18:61069046(-) A-I      intronic
chr18:61069221(-) A-I      intronic
chr18:61081521(-) A-I      intronic
chr18:61081597(-) A-I      intronic
chr18:61085758(-) A-I      intronic
chr18:61061173(-) A-I      intronic
chr18:61061067(-) A-I      intronic
chr18:61061066(-) A-I      intronic
chr18:61061062(-) A-I      intronic
chr18:61085771(-) A-I      intronic
chr18:61085811(-) A-I      intronic
chr18:61057404(-) A-I      3'UTR
chr18:61057422(-) A-I      3'UTR
chr18:61057484(-) A-I      3'UTR
chr18:61057445(-) A-I      3'UTR
chr18:61057534(-) A-I      3'UTR
chr18:61057444(-) A-I      3'UTR
chr18:61057486(-) A-I      3'UTR
chr18:61081895(-) A-I      intronic
chr18:61069104(-) A-I      intronic
chr18:61069098(-) A-I      intronic
chr18:61061139(-) A-I      intronic
chr18:61060036(-) A-I      intronic
chr18:61085740(-) A-I      intronic
chr18:61085905(-) A-I      intronic
chr18:61068648(-) A-I      intronic
chr18:61068659(-) A-I      intronic
chr18:61065648(-) A-I      intronic
chr18:61080606(-) A-I      intronic
chr18:61086430(-) A-I      intronic
chr18:61065622(-) A-I      intronic
chr18:61086503(-) A-I      intronic
chr18:61085781(-) A-I      intronic
chr18:61068652(-) A-I      intronic
chr18:61068593(-) A-I      intronic
chr18:61085827(-) A-I      intronic
chr18:61068658(-) A-I      intronic
chr18:61060086(-) A-I      intronic
chr18:61088088(-) A-I      intronic
chr18:61086620(-) A-I      intronic
chr18:61086574(-) A-I      intronic
chr18:61086405(-) A-I      intronic
chr18:61058524(-) A-I      intronic
chr18:61065940(-) A-I      intronic
chr18:61085861(-) A-I      intronic
chr18:61081520(-) A-I      intronic
chr18:61065647(-) A-I      intronic
chr18:61065817(-) A-I      intronic
chr18:61057409(-) A-I      3'UTR
chr18:61065623(-) A-I      intronic
chr18:61065902(-) A-I      intronic
chr18:61065985(-) A-I      intronic
chr18:61085928(-) A-I      intronic
chr18:61086451(-) A-I      intronic
chr18:61085751(-) A-I      intronic
chr18:61061134(-) A-I      intronic
chr18:61079997(-) A-I      intronic
chr18:61063578(-) A-I      intronic
chr18:61063551(-) A-I      intronic
chr18:61088188(-) A-I      intronic
chr18:61081397(-) A-I      intronic
chr18:61086624(-) A-I      intronic
chr18:61065999(-) A-I      intronic
chr18:61065836(-) A-I      intronic
chr18:61065814(-) A-I      intronic
chr18:61081430(-) A-I      intronic
chr18:61085766(-) A-I      intronic
chr18:61059810(-) A-I      intronic
chr18:61085735(-) A-I      intronic
chr18:61065616(-) A-I      intronic
chr18:61065828(-) A-I      intronic
chr18:61066011(-) A-I      intronic
chr18:61085703(-) A-I      intronic
chr18:61085807(-) A-I      intronic
chr18:61068616(-) A-I      intronic
chr18:61061979(-) A-I      intronic
chr18:61069102(-) A-I      intronic
chr18:61063553(-) A-I      intronic
chr18:61086525(-) A-I      intronic
chr18:61085803(-) A-I      intronic
chr18:61085722(-) A-I      intronic
chr18:61065968(-) A-I      intronic
chr18:61068683(-) A-I      intronic
chr18:61069225(-) A-I      intronic
chr18:61086453(-) A-I      intronic
chr18:61065568(-) A-I      intronic
chr18:61086411(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED VPS4B
chr18:61063742(-) A-I intron -    22327324
chr18:61063546(-) A-G intron -    22484847
chr18:61063578(-) A-G intron -    22484847
chr18:61063624(-) A-G intron -    22484847
chr18:61063742(-) A-G intron -    22484847
chr18:61064161(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VPS4B
chr18:61067927-61067928(-) m6A 3'UTR//CDS//exon       27773535
chr18:61071009-61071010(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr18:61071803-61071804(-) m6A exon//intron       27773535//27371828
chr18:61071816-61071817(-) m6A exon//intron       27773535//27371828
chr18:61071849-61071850(-) m6A exon//intron       27773535//27371828
chr18:61074683-61074684(-) m6A CDS//exon//intron       24981863
chr18:61077548-61077549(-) m6A CDS//exon       24981863//27773535
chr18:61077605-61077606(-) m6A CDS//exon       24981863//27773535
chr18:61078761-61078762(-) m6A CDS//exon       27773535
chr18:61078773-61078774(-) m6A CDS//exon       27773535
chr18:61083078-61083079(-) m6A intron       -
chr18:61089600-61089601(-) m6A 5'UTR//exon       24284625//24981863
chr18:61089639-61089640(-) m6A 5'UTR//exon       24284625//24981863
chr18:61089712-61089713(-) m6A exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ebv-miR-BHRF1-1
Exosome Jurkat-derived T cell line (J77cl20)     21505438
VPS4B
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: ebv-miR-BHRF1-1
Interactor2: VPS4B

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22291592 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.We identified an additional 2,972 CDS miRNA-interaction sites present in at least two libraries, 89.7% of which could be assigned to a miRNA (Table S7).

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